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Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules

⚠ This medicine appears to have been discontinued

The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.

If you were prescribed this medicine, other products containing Nitrofurantoin may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.

Active substance: Nitrofurantoin

Equivalent medicines (same active substance, strength and form)

and 4 more with the same active substance, strength and form

Source: electronic medicines compendium (emc)
Official leaflet: Read the PIL on emc

What it is and what it is used for

FOR Nitrofurantoin (the active substance in Nitrofurantoin 100mg Prolonged-Release Capsules) is an antibiotic. It is used to prevent and treat infections of the bladder, kidney and other parts of the urinary tract.

What you need to know before you take it

E NITROFURANTOIN 100MG PROLONGED-RELEASE CAPSULES DO NOT TAKE Nitrofurantoin 100mg Prolonged-Release Capsules:

  • if you are allergic to Nitrofurantoin, other nitrofurans or any of the other ingredients of this medicine (listed in section 6)
  • if you have a disease of the kidneys which is severely affecting the way they work (ask your doctor if you are not sure)
  • if you are in the final stages of pregnancy (labour or delivery) as there is a risk that it might affect the baby
  • if you have porphyria (blood disorder)
  • if in patients with G6PD (glucose-6-phosphate dehydrogenase) deficiency
  • if in infants under three months of age
  • if you are breast feeding a baby with suspected or known deficiency in an enzyme called G6PD (glucose-6-phosphate dehydrogenase). Tell your doctor if you are not sure about any of the above. Warnings and precautions Talk to your doctor, pharmacist or nurse before taking Nitrofurantoin 100mg Prolonged-Release Capsules:
  • if you have diabetes
  • if you are suffering from any illness causing severe weakness
  • if you have anaemia (a decrease in red blood cells causing pale skin, weakness and breathlessness); a lack of vitamin B or abnormal levels of salts in your blood (your doctor will be able to advise you).
  • if you have a history of allergic reactions.
  • if you have any problems with your kidneys
  • if you have disease of the lungs This medicine can also cause lung disease in patients with no previous medical history affecting their lungs. Lung disease can occur in patients on short-term or long-term treatment. Talk to your doctor if you experience trouble breathing, shortness of breath, a lingering cough, coughing up blood or mucus, or pain or discomfort when breathing. These may be symptoms of side effects affecting the lungs. The above conditions may increase the chance of developing a side effect which causes damage to the nerves, altered sense of feeling, like pins and needles.
  • if you lack an enzyme (body chemical) called glucose-6-phosphate dehydrogenase, which causes your red blood cells to be more easily damaged (this is more common in black people and people of Mediterranean, Middle Eastern or Asian origin. Your doctor will know)
  • if you have any disease of the lungs, liver or nervous system. If you need to take Nitrofurantoin for a number of months, your doctor may want to regularly check how your lungs and liver are working
  • if you have false positive results on testing your urine for glucose
  • if you have urine coloured yellow or brown.
  • if you experience fatigue, yellowing of the skin or eyes, itching, skin rashes, joint pain, abdominal discomfort, nausea, vomiting, loss of appetite, dark urine, and pale or gray-colored stools. It may be symptoms of liver disorder. Other medicines and Nitrofurantoin 100mg Prolonged-Release Capsules: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. If they are taken with Nitrofurantoin their effect or the effect of Nitrofurantoin may be changed. In particular, tell your doctor or pharmacist if you are taking any of the following medicines:
  • Antacids for indigestion (e.g. magnesium trisilicate)
  • Medicines for gout (e.g. probenecid or sulfinpyrazone)
  • Medicines for raised pressure in the eye (glaucoma), such as carbonic anhydrase inhibitors (e.g. acetazolamide)
  • Medicines which make the urine less acidic (e.g. potassium citrate mixture)
  • Medicines for infections, known as quinolones
  • Typhoid vaccine, which is given for the prevention of typhoid. If you are in doubt about any of these medicines ask your doctor or pharmacist. Nitrofurantoin 100mg Prolonged-Release Capsules with food and drink: Nitrofurantoin should be taken at meal times with food or milk. This will help to avoid stomach upset and also to help the absorption. Pregnancy and breast-feeding: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. As far as it is known Nitrofurantoin may be used in pregnancy. However, it should not be used during labour or delivery because there is a possibility that use at this stage may affect the baby. If you want to breast feed, please consult with your doctor first.

Driving and using machines: Nitrofurantoin 100mg Prolonged-Release Capsules may cause dizziness and drowsiness. You should not drive or operate machinery if you are affected this way until such symptoms go away. Nitrofurantoin 100mg Prolonged-Release Capsules contains lactose and sucrose If you have been told by your doctor that you are intolerant to some sugars and have to avoid them, contact your doctor before taking this medicine.

How to take it

NITROFURANTOIN 100MG PROLONGED-RELEASE CAPSULES Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose is: Adults and children over 12 years old: The normal dosage depends on the type of infection you have and instructions should be written on the label provided by the pharmacist. Consult your pharmacist or doctor if these instructions are not clear. The usual doses are:

  • For treatment of bladder infections: One capsule twice a day for seven days
  • For prevention of bladder infections during surgery: One capsule twice a day on the day of the operation and three days thereafter. Use in children Nitrofurantoin 100mg Prolonged-Release Capsules is not recommended for children under 12 years of age. Nitrofurantoin 100mg Prolonged-Release Capsules should be taken with food or milk. Medical Checks: Your doctor will watch carefully for any effects on the liver, lungs, blood or nervous system. Nitrofurantoin may interfere with the results of some tests for glucose in the urine. Method of administration Capsules should be swallowed whole. If you take more Nitrofurantoin 100mg Prolonged-Release Capsules than you should: Consult your doctor or pharmacist immediately or go to the emergency department of the nearest hospital. Always take any left over capsules with you, as well as the container and label, so that the medical staff know what you have taken. If you forget to take Nitrofurantoin 100mg Prolonged-Release Capsules: Do not worry. If you remember later on that day, take that day's dose as usual. If you miss a whole day's dose take the normal dose on the next day. Do not take a double dose to make up for a forgotten capsule. If you are not sure ask your doctor or pharmacist. If you stop taking Nitrofurantoin 100mg Prolonged-Release Capsules: Your doctor will tell you how long to take the treatment. Do not stop earlier than you are told, even if you feel better. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Most of them are mild and disappear when you stop taking Nitrofurantoin. If you experience any of the side effects detailed below or any other side effects, stop taking Nitrofurantoin and consult your doctor. All medicines can cause allergic reactions although serious allergic reactions are rare. If you notice any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body) STOP TAKING your medicine and go to a doctor immediately. Please note that while taking Nitrofurantoin your urine may become coloured dark yellow or brown. This is quite normal and not a reason to stop taking the medicine. If you notice any of the following side effects consult your doctor immediately:

  • Your lungs may react to Nitrofurantoin. This may develop quickly, within a week of starting treatment or very slowly, especially in elderly patients. This may produce fever, chills, cough and shortness of breath associated with pneumonia. Scarring due to damaged lung tissue may occur
  • Nitrofurantoin may cause the liver to become inflamed, producing jaundice (yellowing of the skin or whites of the eyes).
  • Severe reduction in blood cells which can cause weakness, bruising or make infections more likely
  • Blue or purple coloration of the skin due to low oxygen levels. A condition known as cyanosis.
  • Symptoms of fever, flu, abdominal pain, diarrhea, blood in your stool and weakness. These could be signs of a condition known as cutaneous vasculitis.
  • Symptoms of fatigue, abdominal pain, joint pain and swelling. These could be signs of a condition known as hepatitis. In rare cases, it may cause liver failure which may be fatal Other side effects are: Rare: may affect up to 1 in 1,000 people
  • Loss of consciousness (collapse)
  • Damage to bone marrow causing deficiency of the red blood cells (Anaemia) Not known: frequency cannot be estimated from the available data
  • Feeling sick (nausea) and headache
  • Loose stools
  • Loss of appetite, stomach ache, and being sick (vomiting)
  • Diarrhea
  • Dizziness, drowsiness
  • Blood cells have been affected in some patients. This may result in bruising, delayed clotting of the blood, sore throat, fever, anaemia, and a susceptibility to colds or persistent cold
  • The nerves outside the spinal cord may be affected causing changes to the sense of feeling and the use of muscles. In addition headache, extreme changes of mood or mental state, confusion, weakness, blurred vision may occur. These effects may be severe and in some instances permanent
  • A variety of skin rashes or reactions have occurred in some patients. These may appear as flaking skin, a red rash or fever accompanied by rapid heart rate and severe rash with blistering. Other reactions may include inflammation of salivary glands (causing facial pains), inflammation of the pancreas gland (causing severe abdominal pain) and joint pains.
  • Short-term hair loss
  • Raised pressure in the skull (causing severe headaches)
  • Urinary infection by germs which are not sensitive to Nitrofurantoin.
  • Inflammation of small blood vessel walls, causing skin lesions
  • Liver inflammation due to turn of immune system against liver cells
  • Inflammation of kidney tissue surrounding tubules, causing renal impairment Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the MHRA yellow card scheme website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

How to store it

NITROFURANTOIN 100MG PROLONGED-RELEASE CAPSULES Keep this medicine out of the sight and reach of children.

Do not store above 30°C (aluminium/aluminium). Do not store above 25°C (For PVC/polyethylene/aclar/aluminium blisters). Store in the original package to protect from light and moisture. Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.

Contents of the pack and other information

What Nitrofurantoin 100mg Prolonged-Release Capsules contains: The active substance is 100mg nitrofurantoin in each capsule. The other ingredients are talc, corn starch, lactose, carbopol, povidone, sugar and magnesium stearate. The capsule shell contains gelatin, quinoline yellow (E104), titanium dioxide (E171) and FD&C Blue No.2 (E132). The printing ink contains shellac, propylene glycol (E1520), titanium dioxide (E171) black iron oxide (E172), ammonium hydroxide (E527) and simethicone. What Nitrofurantoin 100mg Prolonged-Release Capsules looks like and contents of the pack: Nitrofurantoin 100mg Prolonged-Release Capsules has an opaque blue cap and opaque yellow body and bears the monogram "GS 100". The capsules are available in blister strips of 14. Marketing Authorisation Holder: Mercury Pharmaceuticals Ltd, Dashwood House, 69 Old Broad Street, London, EC2M 1QS, United Kingdom Manufacturer: Famar A.V.E., 7 Anthousa Avenue, 15344 Anthousa, Attiki, Greece This leaflet was last revised in April 2026.

Frequently asked questions about Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules

How do I take Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules?

Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules comes as capsule containing 100mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.

What is the active substance in Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules?

The active substance in Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules is nitrofurantoin.

Are there equivalent medicines to Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules?

Medicines with the same active substance, strength and form include: Nitrofurantoin 100 mg Capsules, Nitrofurantoin 100 mg Hard Capsules, Nitrofurantoin 100 mg capsules. In total there are 9 equivalent products. They are interchangeable only if your prescriber or pharmacist says so.

Where does this information come from?

This leaflet reproduces the patient information leaflet approved for Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.

Can I get Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules without a prescription?

Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.

About this leaflet

The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.

Medical disclaimer: This page is for information only and does not replace advice from your doctor or pharmacist. Always read the leaflet supplied with your medicine. If you are unwell, call NHS 111; in an emergency, call 999.

Medicines with the same active substance: Nitrofurantoin (20 medicines)
See every medicine containing this substance, or browse the full A–Z of active substances.
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
Technical information intended for healthcare professionals (doctors and pharmacists). The Summary of Product Characteristics (SmPC) is the official document approved by the MHRA/EMA. It does not replace the patient leaflet or a doctor’s advice.

4.1. Therapeutic indications

For the treatment of and prophylaxis against acute or recurrent, uncomplicated lower urinary tract infections or pyelitis either spontaneous or following surgical procedures. It is indicated in adults, children and infants over 12 years of age.

Nitrofurantoin is specifically indicated for the treatment of infections when due to susceptible strains of Escherichia coli, Enterococci, Staphylococci, Citrobacter, Klebsiella and Enterobacter.

Most strains of Proteus and Serratia are resistant. All Pseudomonas strains are resistant.

Nitrofurantoin 100mg Prolonged-Release Capsules is not indicated for the treatment of associated renal cortical or perinephric abscesses.

4.2. Posology and method of administration

Posology

Adults and children over 12 years of age.

The dose should be taken with food or milk (e.g. at meal times).

Acute or recurrent uncomplicated UTI and pyelitis -100mg twice daily for seven days.

Surgical Prophylaxis - 100 mg twice daily on the day of the procedure and 3 days thereafter.

Elderly

Provided there is no significant renal impairment, in which nitrofurantoin is contraindicated, the dosage should be that for any normal adult.

See precaution and risks to elderly patients associated with long term therapy (see section 4.8).

Children under 12 years

Nitrofurantoin 100mg Prolonged-Release Capsules is a fixed dosage and is therefore not suitable for children under 12 years

Renal impairment

Nitrofurantoin is contraindicated in patients with renal dysfunction and in patients with an eGFR below of less than 45 ml/minute (see sections 4.3 & 4.4).

Method of administration

For oral use

4.3. Contraindications

• Hypersensitivity to the active substance, other nitrofurans or to any of the excipients listed in section 6.1.

• Patients suffering from renal dysfunction with an eGFR below 45 ml/minute.

• G6PD deficiency (see also Section 4.6)

• Acute porphyria.

• In infants under three months of age as well as pregnant patients at term (during labour and delivery) because of the theoretical possibility of haemolytic anaemia in the foetus or in the newborn infant due to immature erythrocyte enzyme systems.

4.4. Special warnings and precautions for use

Nitrofurantoin is not effective for the treatment of parenchymal infections of a unilaterally functioning kidney. A surgical cause for infection should be excluded in recurrent or severe cases.

Nitrofurantoin may be used with caution as short-course therapy only for the treatment of uncomplicated lower urinary tract infection in individual cases with an eGFR between 30-44 ml/min to treat resistant pathogens, when the benefits are expected to outweigh the risks.

Since pre-existing conditions may mask hepatic or pulmonary adverse reactions, nitrofurantoin should be used with caution in patients with pulmonary disease, hepatic dysfunction, neurological disorders and allergic diathesis.

Peripheral neuropathy and susceptibility to peripheral neuropathy, which may become severe or irreversible has occurred and may be life threatening. Therefore, treatment should be stopped at the first signs of neural involvement (paraesthesiae).

Nitrofurantoin should be used with caution in patients with anaemia, diabetes mellitus, electrolyte imbalance, debilitating conditions, and vitamin B (particularly folate) deficiency.

Pulmonary adverse reactions

Acute, subacute and chronic pulmonary reactions have been observed in patients treated with nitrofurantoin. If these reactions occur, nitrofurantoin should be discontinued immediately. Signs of pulmonary damage include difficulty and or pain when breathing, shortness of breath and coughing up blood or mucus.

Chronic pulmonary reactions

Chronic pulmonary reactions (including pulmonary fibrosis and diffuse interstitial pneumonitis) can develop insidiously and can often occur in elderly patients. Close monitoring of the lung diseaseof patients receiving long-term therapy is indicated (especially in the elderly).

Acute pulmonary reactions

Pulmonary reactions may be acute and usually occur within the first week of treatment. Increased vigilance for respiratory symptoms in patients who have just started therapy is warranted (especially in the elderly).

Urine may be coloured yellow or brown after taking Nitrofurantoin. Patients on Nitrofurantoin are susceptible to false positive urinary glucose (if tested for reducing substances).

Nitrofurantoin should be discontinued at any signs of haemolysis in those with suspected glucose-6-phosphate dehydrogenase deficiency.

Gastrointestinal reactions may be minimised by taking the drug with food or milk, or by adjustment of dosage.

Hepatotoxicity

Hepatic reactions, including hepatitis, autoimmune hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis, occur rarely. Fatalities have been reported. The onset of chronic active hepatitis may be insidious, and patients should be monitored periodically for changes in biochemical tests that would indicate liver injury. If hepatitis occurs, the drug should be withdrawn immediately and appropriate measures should be taken.

For long term treatment monitor the patient closely for appearance of hepatic or pulmonary symptoms and other evidence of toxicity.

Discontinue treatment with nitrofurantoin if otherwise unexplained pulmonary, hepatotoxic, haematological or neurological syndromes occur.

Excipients

Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.

4.5. Interaction with other medicinal products and other forms of interaction

1. Increased absorption with food or agents delaying gastric emptying.

2. Decreased absorption with magnesium trisilicate.

3. Decreased renal excretion of Nitrofurantoin by probenecid and sulfinpyrazone.

4. Decreased anti-bacterial activity by carbonic anhydrase inhibitors and urine alkalisation.

5. Anti-bacterial antagonism by quinolone anti-infectives.

6. Interference with some tests for glucose in urine.

7. As Nitrofurantoin belongs to the group of Antibacterials, it will have the following resulting interactions:

• Typhoid Vaccine (oral): Antibacterials inactivate oral typhoid vaccine.

4.6. Fertility, pregnancy and lactation

Pregnancy

Animal studies with nitrofurantoin have shown no teratogenic effects, however study in rats has shown reproductive toxicity (see section 5.3). Nitrofurantoin has been in extensive clinical use since 1952 and its suitability in human pregnancy has been well documented. However, as with all other drugs, the maternal side effects may adversely affect course of pregnancy. The drug should be used at the lowest dose as appropriate for a specific indication, only after careful assessment.

Nitrofurantoin is however contraindicated in infants under three months of age and in pregnant women during labour and delivery because of the possible risk of haemolysis of the infants immature red cells.

Breast-feeding

Breast feeding an infant known or suspected to have an erythrocyte enzyme deficiency (including G6PD deficiency), must be temporarily avoided, since Nitrofurantoin is detected in trace amounts in breast milk.

Fertility

No data available

4.7. Effects on ability to drive and use machines

Nitrofurantoin 100mg Prolonged-Release Capsules may cause dizziness and drowsiness. Patients should be advised not to drive or operate machinery if affected in this way until such symptoms go away.

4.8. Undesirable effects

A tabulated list of undesirable effects is outlined below:

The undesirable effects are listed according to organ systems and following frequencies:

Rare (≥1/10,000 to <1/1,000)

Not known (cannot be estimated from the available data)

System organ class

Frequency

Adverse reaction

Infections and infestations

Not known

Superinfections by fungi or resistant organisms such as Pseudomonas. However, these are limited to the genitourinary tract

Blood and lymphatic system disorders

Rare

Not known

Aplastic anaemia

Agranulocytosis, leucopenia, granulocytopenia, haemolytic anaemia, thrombocytopenia,glucose¬6-phosphatedehydrogenase deficiency anaemia, megaloblasticanaemia and eosinophilia

Immune system disorders

Not known

Anaphylaxis, , angioneuroticoedema , cutaneous vasculitis and allergic skin reactions

Psychiatric disorders

Not known

psychotic reactions, depression, euphoria, confusion

Nervous system disorders

Not known

Benign intracranial hypertension, peripheral neuropathy including optic neuritis (sensory as well as motor involvement), nystagmus, vertigo, dizziness, headache and drowsiness.

Cardiac disorders

Rare

Collapse and cyanosis

Respiratory, thoracic and mediastinal disorders

Not known

Pulmonary fibrosis; possible association with lupus-erythematous-like syndrome.

acute pulmonary reactions *

subacute pulmonary reactions, *

chronic pulmonary reactions, *

cough, dyspnoea,

Gastrointestinal disorders

Not known

Sialaodenitis, pancreatitis, , anorexia, emesis, abdominal pain, diarrhea and nausea

Hepatobiliary disorders

Not known

Chronic active hepatitis**, hepatic necrosis, autoimmune hepatitis, cholestatic jaundice

Skin and subcutaneous tissue disorders

Not known

Lupus-like syndrome associated with pulmonary reaction.

Drug Rash With Eosinophilia And Systemic Symptoms (DRESS syndrome), exfoliative dermatitis and erythema multiforme (including Stevens-Johnson Syndrome), maculopapular, erythematous or eczematous eruptions,urticaria, rash, and pruritis, Transient alopecia

Renal and urinary disorders

Not known

Interstitial nephritis, yellow or brown discolouration of urine,

General disorders and administration site conditions

Not known

Asthenia, fever, chills, drug fever and arthralgia

Investigations

Not known

False positive urinary glucose

* Acute pulmonary reactions are commonly manifested by fever, chills, cough, chest pain, dyspnoea, pulmonary infiltration with consolidation or pleural effusion on chest x-ray, and eosinophilia. In subacute pulmonary reactions, fever and eosinophilia occur less often than in the acute form.

Chronic pulmonary reactions occur rarely in patients who have received continuous therapy for six months or longer and are more common in elderly patients. Changes in ECG have occurred, associated with pulmonary reactions

**Can be fatal

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the MHRA yellow card scheme website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

4.9. Overdose

Symptoms

Symptoms and signs of overdose include gastric irritation, nausea and vomiting.

Management

There is no specific antidote. However, Nitrofurantoin can be haemodialysed. Standard treatment is by induction of emesis or by gastric lavage in cases of recent ingestion. Monitoring of full blood count, liver function tests and pulmonary function, are recommended. A high fluid intake should be maintained to promote urinary excretion of the drug.

💬 Ask about this leaflet

Ask anything about Nitrofurantoin Mercury Pharma 100mg Prolonged-Release Capsules. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.

Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.

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