What it is and what it is used for

for This medicine has been prescribed for you for relieving moderate, long-lasting pain that requires the use of a strong painkiller. It contains buprenorphine which belongs to a class of medicines called opioids, which are 'pain relievers'. This medicine has been prescribed to you and should not be given to anyone else. Opioids can cause addiction and you may get withdrawal symptoms if you stop using it suddenly. Your prescriber should have explained how long you will be using it for, and when it is appropriate to stop, how to do this safely. Sevodyne should not be used to relieve acute pain. Sevodyne patches act through the skin. After application, buprenorphine passes through the skin into the blood. Each patch lasts for seven days.

What you need to know before you take it

e Sevodyne Do not use Sevodyne: if you are allergic to buprenorphine or any of the other ingredients of this medicine (listed in section 6); if you have breathing problems; if you are addicted to drugs; if you are taking a type of medicine known as a monoamine oxidase inhibitor (examples include tranylcypromide, phenelzine, isocarboxazid, moclobemide and linezolid), or you have taken this type of medicine in the last two weeks; if you suffer from myasthenia gravis (a condition in which the muscles become weak); if you have previously suffered from withdrawal symptoms such as agitation, anxiety, shaking or sweating upon stopping taking alcohol; for acute post-operative pain because of the increased risk of dependency and developing serious breathing problems. If you are going to have an operation, or have just had an operation, please tell the doctor at the hospital if you are taking Sevodyne. Your doctor may adjust your dose. Sevodyne must not be used to treat symptoms associated with drug withdrawal. Warnings and precautions Talk to your prescriber before using this medicine if you: suffer from seizures, fits or convulsions; suffer from a breathing related sleep disorder (sleep apnoea); have a severe headache or feel sick due to a head injury or increased pressure in your skull (for instance due to brain disease). This is because the patches may make symptoms worse or hide the extent of a head injury; are feeling light-headed or faint; have severe liver problems; have a high temperature, as this may lead to larger quantities of the active ingredient being absorbed into the blood than normal; are treated with antidepressants. The use of these medicines together with Sevodyne can lead to serotonin syndrome, a potentially life-threatening condition (see 'Other medicines and Sevodyne'); are or have ever been addicted to opioids, alcohol, prescription medicines, or illegal drugs; have previously suffered from withdrawal symptoms such as agitation, anxiety, shaking or sweating, when you have stopped taking alcohol or drugs; feel you need to use more of Sevodyne to get the same level of pain relief, this may mean you are becoming tolerant to the effects of this medicine or are becoming addicted to it. Speak to your prescriber who will discuss your treatment and may change your dose or switch you to an alternative pain reliever; are a smoker; have ever had problems with your mood (depression, anxiety or a personality disorder) or have been treated by a psychiatrist for other mental illnesses; suffer from constipation. Tolerance, dependence, and addiction This medicine contains buprenorphine which is an opioid medicine. Repeated use of opioids can result in the drug being less effective (you become accustomed to it, known as tolerance). Repeated use of Sevodyne can also lead to dependence, abuse, and addiction, which may result in life-threatening overdose. The risk of these side effects can increase with a higher dose and longer duration of use. Dependence or addiction can make you feel that you are no longer in control of how much medicine you need to take or how often you need to take it. The risk of becoming dependent or addicted varies from person to person. You may have a greater risk of becoming dependent on or addicted to Sevodyne if: You or anyone in your family have ever abused or been dependent on alcohol, prescription medicines or illegal drugs ('addiction'). You are a smoker. You have ever had problems with your mood (depression, anxiety, or a personality disorder) or have been treated by a psychiatrist for other mental illnesses. If you notice any of the following signs whilst taking Sevodyne, it could be a sign that you have become dependent or addicted: You need to take the medicine for longer than advised by your doctor. You need to take more than the recommended dose. You might feel that you need to carry on taking your medicine, even when it doesn't help to relieve your pain. You are using the medicine for reasons other than prescribed, for instance, 'to stay calm' or 'help you sleep'. You have made repeated, unsuccessful attempts to quit or control the use of the medicine. When you stop taking the medicine you feel unwell, and you feel better once taking the medicine again ('withdrawal effects'). If you notice any of these signs, speak to your doctor to discuss the best treatment pathway for you, including when it is appropriate to stop and how to stop safely (see section 3, If you stop taking Sevodyne).

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Sleep-related breathing disorders Sevodyne can cause sleep-related breathing disorders such as sleep apnoea (breathing pauses during sleep) and sleep related hypoxemia (low oxygen level in the blood). The symptoms can include breathing pauses during sleep, night awakening due to shortness of breath, difficulty in maintaining sleep or excessive drowsiness during the day. If you or another person observe these symptoms, contact your doctor. A dose reduction may be considered by your doctor. This medicine may cause application site reactions which are usually presented by a mild or moderate skin inflammation, and their typical appearance may include redness, swelling, itching, rash, small blisters, and painful/ burning sensation at the application site. Most commonly the cause is skin irritation, and these reactions stop after Sevodyne patches are removed. More serious allergic reactions may occur such as blisters with discharge, which may spread outside the application site and may not resolve rapidly after Sevodyne removal. Chronic allergic reactions may lead to open wounds, bleeding, ulcers, skin discolouration and infections. If you notice any of the above skin reactions, please contact your doctor. This medicine may increase your sensitivity to pain particularly at high doses. Tell your doctor if this happens. A reduction in your dose or a change in your medicine may be necessary. If you have recently had an operation, please speak to your doctor before using these patches. Athletes should be aware that this medicine may cause a positive reaction to sports doping control tests. Similar to other opioids, this medicine may affect the normal production of hormones in the body, such as cortisol or sex hormones, particularly if you have taken high doses for a long period of time. Children and adolescents Do not give this medicine to children and adolescents below 18 years. Other medicines and Sevodyne Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Some medicines may increase the side effects of Sevodyne and may sometimes cause very serious reactions. Do not take any other medicines whilst using Sevodyne without first talking to your doctor, especially: Anti-depressants such as moclobemide, tranylcypromine, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, doxepine, or trimipramine. These medicines may interact with Sevodyne and you may experience symptoms such as involuntary, rhythmic contractions of muscles, including the muscles that control movement of the eye, agitation, hallucinations, coma, excessive sweating, tremor, exaggeration of reflexes, increased muscle tension, body temperature above 38°C. Contact your doctor when experiencing such symptoms. Sevodyne must not be used together with a type of medicine known as a monoamine oxidase inhibitor (examples include tranylcypromide, phenelzine, isocarboxazid, moclobemide and linezolid), or if you have taken this type of medicine in the last two weeks. If you take some medicines such as phenobarbital or phenytoin (medicines commonly used to treat seizures, fits or convulsions), carbamazepine (a medicine to treat seizures, fits or convulsions and certain pain conditions), or rifampicin (a medicine to treat tuberculosis) the effects of Sevodyne may be reduced. Sevodyne may make some people feel drowsy, sick or faint or make them breathe more slowly or weakly. These side effects may be made worse if other medicines that produce the same effects are taken at the same time. These include certain medicines to treat pain, depression, anxiety, psychiatric or mental disorders, medicines to help you sleep, medicines to treat high blood pressure such as clonidine, other opioids (which may be found in painkillers or certain cough mixtures e.g. morphine, dextropropoxyphene, codeine, dextromethorphan, noscapine), antihistamines which make you drowsy, or anaesthetics such as halothane. Concomitant use of Sevodyne and sedative medicines such as benzodiazepines (medicines used to treat anxiety or to help you sleep) or related drugs increases the risk of drowsiness, difficulties in breathing (respiratory depression), coma and may be life-threatening. Because of this, concomitant use should only be considered when other treatment options are not possible. However if your doctor does prescribe Sevodyne together with sedative medicines the dose and duration of concomitant treatment should be limited by your doctor. Please tell your doctor about all sedative medicines you are taking, and follow your doctor's dose recommendation closely. It could be helpful to inform friends or relatives to be aware of the signs and symptoms stated above. Contact your doctor when experiencing such symptoms. Gabapentin or pregabalin to treat epilepsy or pain due to nerve problems (neuropathic pain). Medicines to treat depression. Medicines used to treat allergies, travel sickness or nausea (antihistamines or antiemetics). Medicines to treat psychiatric disorders (antipsychotics or neuroleptics). Muscle relaxants. Medicines to treat Parkinson's disease. Sevodyne with alcohol Alcohol may make some of the side effects worse and you may feel unwell if you drink alcohol whilst wearing Sevodyne. Drinking alcohol whilst using Sevodyne may also affect your reaction time. Pregnancy, breast-feeding and fertility Do not use Sevodyne if you are pregnant or breast-feeding, think you might be pregnant or are planning to have a baby, unless you have discussed this with your prescriber and the benefits of treatment are considered to outweigh the potential harm to the baby. If you use Sevodyne during pregnancy, your baby may become dependent and experience withdrawal symptoms after the birth which may need to be treated. Do not use Sevodyne while you are breast-feeding as buprenorphine passes into breast milk and will affect your baby. Ask your doctor or pharmacist for advice before using this medicine. Driving and using machines Sevodyne may affect your reactions to such an extent that you may not react adequately or quickly enough in the event of unexpected or sudden occurrences. This applies particularly: at the beginning of treatment; if you are taking medicines to treat anxiety or help you sleep; if your dose is increased. If you are affected (e.g. feel dizzy, drowsy or have blurred vision), you should not drive or operate machinery whilst using Sevodyne, or for 24 hours after removing the patch. This medicine can affect your ability to drive as it may make you sleepy or dizzy. Do not drive while taking this medicine until you know how it affects you. It is an offence to drive if this medicine affects your ability to drive. However you would not be committing an offence if: The medicine has been prescribed to treat a medical or dental problem; and You have taken it according to the instructions given by the prescriber or in the information provided with the medicine. It was not affecting your ability to drive safely. Talk to your doctor or pharmacist if you are not sure whether it is safe for you to drive while taking this medicine.

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How to take it

Sevodyne Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Before starting treatment and regularly during treatment, your doctor will discuss with you what you may expect from using Sevodyne, when and how long you need to take it, when to contact your doctor, and when you need to stop it (see also, If you stop using Sevodyne). Different strengths of Sevodyne are available. Your doctor will decide which strength of Sevodyne will suit you best. When people first start using Sevodyne, they often experience some nausea and vomiting (see section 4). This usually passes after the first week of treatment. It's a good idea to book a follow-up appointment with your doctor a week or two after you first start using Sevodyne patches to ensure that you are taking the correct dose and to manage any side effects. During treatment, your doctor may change the patch you use to a smaller or larger one if necessary or tell you to use a combination of up to two patches. Do not cut or divide the patch or use a higher dose than recommended. You should not apply more than two patches at the same time up to a maximum total dose of 40 micrograms/hour. If you feel that the effect of the Sevodyne is too weak or too strong, talk to your doctor or pharmacist. Adults and elderly patients Unless your doctor has told you differently, attach one Sevodyne patch (as described in detail below) and change it every seventh day, preferably at the same time of day. Your doctor may wish to adjust the dose after 3-7 days until the correct level of pain control has been found. If your doctor has advised you to take other painkillers in addition to the patch, strictly follow the doctor's instructions, otherwise you will not fully benefit from treatment with Sevodyne. The patch should be worn for 3 full days before increasing the dose, this is when the maximum effect of a given dose is established. Patients with kidney disease/dialysis patients In patients with kidney disease, no change in dose is necessary. Patients with liver disease In patients with liver disease, the effects and period of action of Sevodyne may be affected and your doctor will therefore check on you more closely. Patients under 18 years of age Sevodyne should not be used in patients below the age of 18 years.

Method of administration Sevodyne transdermal patch is for transdermal use. Sevodyne acts through the skin. After application, buprenorphine passes through the skin into the blood. Before applying the transdermal patch Choose an area of non-irritated, intact skin on your upper arm, outer arm, upper chest, upper back or side of the chest. (See accompanying illustrations). Ask for assistance if you cannot apply the patch yourself.

•

Upper arm

or

Back

or

Front

or

Sevodyne patch should be applied to a relatively hairless or nearly hairless skin site. If no suitable hair free sites

• The are available, the hairs should be cut off with a pair of scissors. Do not shave them off.
• Avoid skin which is red, irritated or has any other blemishes, for instance large scars.
• The area of skin you choose must be dry and clean. If necessary, wash it with cold or lukewarm water. not use soap, alcohol, oil, lotions or other detergents. After a hot bath or shower, wait until your skin is
• Do completely dry and cool. Do not apply lotion, cream or ointment to the chosen area. This might prevent your patch from sticking properly. Applying the transdermal patch Step 1: Each transdermal patch is sealed in a sachet. Just before use, cut the sachet along the sealed edge with scissors. Take out the transdermal patch. Do not use the patch if the sachet seal is broken.

•

2:

• SThetepsticky side of the transdermal patch is

covered with a transparent protective foil. Carefully peel off one part of the foil. Try not to touch the sticky part of the transdermal patch.

tep 3:

• SStick the transdermal patch on to the area of skin you have chosen and remove the remaining foil.

tep 4:

• SPress the transdermal patch against your skin with the palm of your hand and count slowly to 30. Make sure that the whole transdermal patch is in contact with your skin, especially at the edges.

Wearing the transdermal patch You should wear the patch for seven days. Provided that you have applied the patch correctly, there is little risk of it coming off. If the edges of the patch begin to peel off, they may be taped down with a suitable skin tape. You may shower, bathe or swim whilst wearing it. Do not expose the patch to extreme heat (e.g. heating pads, electric blanket, heat lamps, sauna, hot tubs, heated water beds, hot water bottle, etc) as this may lead to larger quantities of the active ingredient being absorbed into the blood than normal. External heat may also prevent the patch from sticking properly. If you have a high temperature this may alter the effects of Sevodyne (see 'Warnings and precautions' section above). In the unlikely event that your patch falls off before it needs changing, do not use the same patch again. Stick a new one on straight away (see 'Changing the transdermal patch' below). Changing the transdermal patch Take the old transdermal patch off. Fold it in half with the sticky side inwards. Open and take out a new patch. Use the empty sachet to dispose of the old patch. Discard the sachet safely. Even used patches contain some active ingredient that may harm children or animals, so make sure your used patches are always kept out of their sight and reach. Stick a new transdermal patch on a different appropriate skin site (as described above). You should not apply a new patch to the same site for 3-4 weeks. Remember to change your patch at the same time of day. It is important that you make a note of the time of day. Duration of treatment Your prescriber should have discussed with you how long the course of treatment will last. They will arrange a plan for stopping treatment. This will outline how to gradually reduce the dose and stop using the medicine. Do not stop treatment without consulting a doctor, because your pain may return and you may feel unwell (see also 'If you stop using Sevodyne' below). If you feel that the effect of the Sevodyne is too weak or too strong, talk to your doctor or pharmacist. If you use more Sevodyne than you should As soon as you discover that you have used more patches than you should, remove all patches and call your doctor or hospital straight away. People who have taken an overdose may feel very sleepy and sick. They may also have breathing difficulties or lose consciousness and may need emergency treatment in hospital. When seeking medical attention make sure that you take this leaflet and any remaining patches with you to show to the doctor. If you forget to apply Sevodyne Stick a new patch on as soon as you remember. Also make a note of the date, as your usual day of changing may now be different. If you are very late changing your patch, your pain may return. In this case, please contact your doctor. Do not apply additional patches to make up for the forgotten application. If you stop using Sevodyne Do not suddenly stop using this medicine. If you want to stop using this medicine, discuss this with your prescriber first. They will tell you how to do this, usually by reducing the dose gradually so that any unpleasant withdrawal effects are kept to a minimum. Withdrawal symptoms such as restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, shaking, shivering or sweating may occur if you suddenly stop using this medicine. The pain relieving effect of Sevodyne is maintained for some time after removal of the patch. You should not start another opioid analgesic (strong painkiller) within 24 hours after removal of the patch.

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If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Serious side effects that may be associated with Sevodyne are similar to those seen with other strong painkillers and include difficulty in breathing and low blood pressure. This medicine can cause allergic reactions, although serious allergic reactions are rare. Remove the patch and tell your doctor immediately if you get any sudden wheeziness, difficulties in breathing, swelling of the eyelids, face or lips, rash or itching especially those covering your whole body. As with all strong painkillers there is a risk that you may become addicted or reliant on Sevodyne. In patients treated with buprenorphine, the following other side effects have been reported: Very common (may affect more than 1 in 10 people): Headache, dizziness, drowsiness. Constipation, feeling or actually being sick. Itchy skin. Rash, redness, itching, inflammation or swelling of the skin at the application site. Common (may affect up to 1 in 10 people): Loss of appetite. Confusion, depression, anxiety, difficulty in sleeping, nervousness, shaking (tremors). Shortness of breath. Abdominal pain or discomfort, diarrhoea, indigestion, dry mouth. Sweating, rash, skin eruptions. Tiredness, a feeling of unusual weakness, muscle weakness, swelling of hands, ankles or feet. Joint pain. Uncommon (may affect up to 1 in 100 people): Restlessness, agitation, a feeling of extreme happiness, hallucinations, nightmares, decreased sexual drive, aggression. Changes in taste, difficulty in speaking, reduced sensitivity to pain or touch, tingling or numbness. Loss of memory, migraine, fainting, problems with concentration or co-ordination. Dry eyes, blurred vision. A ringing or buzzing sound in the ears, a feeling of dizziness or spinning. High or low blood pressure, chest pain, fast or irregular heartbeat. Cough, hiccups, wheezing. Wind.

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• Weight loss.
• Dry skin.
• Spasms, aches and pains. in beginning the flow of urine, inability to fully empty the bladder or involuntary loss of urine
• Difficulty from the bladder.
• Fever.
• An increase in accidental injuries (e.g. falls).
• Withdrawal symptoms such as agitation, anxiousness, sweating or shaking upon stopping using Sevodyne.

If you need to have blood tests remind your doctor that you are using Sevodyne. This is important because Sevodyne may change the way your liver works and this could affect the results of some blood tests. Rare (may affect up to 1 in 1,000 people): Angina (chest pain associated with heart disease). Mental disorder. Difficulties with balance. Swelling of the eyelids or face, a reduction in size of the pupils in the eye. Difficulty in breathing, worsening of asthma, over breathing. A feeling of faintness, especially on standing up. Difficulty in swallowing. Local allergic reaction with marked signs of swelling (in such cases treatment should be stopped). Swelling and irritation inside the nose. Decreased erection, sexual dysfunction. A flu-like illness. Flushing of the skin. Dehydration. Very rare (may affect up to 1 in 10,000 people): Muscle twitching. Mood swings. Ear pain. Blisters. Not known (frequency cannot be estimated from the available data): Problems with breathing during sleep (sleep apnoea syndrome), see section 2 'Warnings and precautions'. Seizures, fits or convulsions. Inflammation of the bowel wall. Symptoms may include fever, vomiting and stomach pain or discomfort. An increased sensitivity to pain. Colicky abdominal pain or discomfort. Feeling detached from oneself. Withdrawal symptoms in babies born to mothers who have been given Sevodyne in pregnancy may include high-pitched crying, irritability and restlessness, shaking (tremor), feeding difficulties, sweating and not putting on weight. Dependence and addiction (see section 'How do I know if I am addicted?'). A need to take increasingly higher doses of this medicine to obtain the same level of pain relief (tolerance). Contact dermatitis (skin rash with inflammation which may include burning sensation), skin discolouration. Drug Withdrawal When you stop using Sevodyne, you may experience drug withdrawal symptoms, which include restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, shaking, shivering or sweating. How do I know if I am addicted? If you notice any of the following signs whilst using Sevodyne, it could be a sign that you have become addicted. You need to use the medicine for longer than advised by your prescriber. You feel you need to use more than the recommended dose. You are using the medicine for reasons other than prescribed. When you stop using the medicine you feel unwell, and you feel better once using the medicine again. If you notice any of these signs, it is important you talk to your prescriber. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme (website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store). By reporting side effects, you can help provide more information on the safety of this medicine.

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How to store it

Sevodyne

• Keep this medicine out of the sight and reach of children. not use this medicine after the expiry date which is stated on the carton and sachet after EXP. The expiry date
• Do refers to the last day of that month.
• 5 microgram/h, 10 microgram/h and 15 microgram/h: Do not store above 25°C.
• 20 microgram/h: This medicine does not require any special storage conditions.
• Do not use the patch if the sachet seal is broken.
• Used patches must be folded over on themselves with the adhesive layer inwards, and discarded safely. not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away
• Do medicines you no longer use. These measures will help protect the environment. this medicine in a safe and secure place, where other people cannot access it. It can cause serious harm and be
• Store fatal to people who may take this medicine by accident, or intentionally when it has not been prescribed for them.

Contents of the pack and other information

What Sevodyne patches contain The active substance is buprenorphine. 5 microgram/h: Each transdermal patch contains 5mg of buprenorphine in a patch size of 6.25cm2 and releases 5 micrograms of buprenorphine per hour (over a period of 7 days). 10 microgram/h: Each transdermal patch contains 10mg of buprenorphine in a patch size of 12.5cm2 and releases 10 micrograms of buprenorphine per hour (over a period of 7 days). 15 microgram/h: Each transdermal patch contains 15mg of buprenorphine in a patch size of 18.75 cm2 and releases 15 micrograms of buprenorphine per hour (over a period of 7 days). 20 microgram/h: Each transdermal patch contains 20mg of buprenorphine in a patch size of 25cm2 and releases 20 micrograms of buprenorphine per hour (over a period of 7 days). The other ingredients are: Adhesive matrix (containing buprenorphine): povidone K90, levulinic acid, oleyl oleate, poly[acrylic acid-cobutylacrylate-co-(2-ethylhexyl)acrylate-co-vinylacetate] (5:15:75:5), Adhesive matrix (without buprenorphine): poly[(2-ethylhexyl)acrylate-co-glycidylmethacrylate-co(2-hydroxyethyl)acrylate-co-vinylacetate] (68:0,15:5:27), Separating foil between adhesive matrices with and without buprenorphine: Polyethylene terephthalate film; Backing foil: Polyester; Release liner: Polyethylene terephthalate film, siliconised; Blue printing ink. What Sevodyne looks like and contents of the pack Transdermal patch Four sizes are available. 5 microgram/h: Each transdermal patch is beige coloured with rounded corners and is imprinted with 'Buprenorphin' and '5μg/h' 10 microgram/h: Each transdermal patch is beige coloured with rounded corners and is imprinted with 'Buprenorphin' and '10μg/h' 15 microgram/h: Each transdermal patch is beige coloured with rounded corners and is imprinted with 'Buprenorphin" and '15μg/h' 20 microgram/h: Each transdermal patch is beige coloured with rounded corners and is imprinted with 'Buprenorphin' and '20μg/h' One transdermal patch is sealed in one child-resistant sachet. The patches are available in cartons containing 1, 2, 3, 4, 5, 8, 10 or 12 transdermal patches. Not all pack sizes may be marketed.

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Marketing Authorisation Holder Aspire Pharma Ltd, Unit 4, Rotherbrook Court Bedford Road, Petersfield, Hampshire, GU32 3QG, United Kingdom Manufacturer Labtec GmbH, Heykenaukamp 10, 21147 Hamburg, Germany This leaflet was last revised in January 2025 1010311-P14.2

16181-90047-11

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Aspire Pharma Limited Sevodyne (Buprenorphine) PL35533/0059-61, 0135 Leaflet 480mm x 280mm Safety update to section 2 14.2 4.2.25 Black 9pt Strada Condensed InDesign CC

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