Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pancrex V 125 mg hard capsules
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Pancreatin may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
What it is and what it is used for
for
Pancrex V contains the active substance pancreatin. Pancreatin is a combination of enzymes normally produced by the pancreas which help to digest protein, fat, starch and sugars in the food that you eat. Pancreatin is given to people who do not produce enough enzymes to digest their food properly, in conditions such as cystic fibrosis, persistent inflammation of the pancreas, and when the pancreas has been removed. Pancrex V may also be used when the stomach has been removed, as an aid to digestion. These low-dose capsules may be used when small amounts of pancreatin are required, such as in newborns. The pancreatin in Pancrex V is derived from pancreases of pigs. 2.
What you need to know before you take it
e Pancrex V
Do not take Pancrex V If you are allergic to pancreatin or any of the other ingredients of this medicine (listed in section 6). Warnings and precautions Pan125mgCap-LPL-UK-6
Talk to your doctor or pharmacist before taking Pancrex V. Some irritation of the skin of the mouth may occur if the capsules are chewed or the contents kept in the mouth. Irritation of the anus may also occur, which may be prevented by use of a barrier cream. It is possible that some people may be allergic to Pancrex V. Allergic/asthmatic reactions have occasionally occurred on handling the capsule contents. Signs of an allergy to something include rash, wheezing, breathlessness, swollen eyelids, face or lips, and in extreme cases collapse. In the unlikely event that you should get any of these symptoms soon after taking Pancrex V, do not take any more. Tell a doctor straight away and take the packaging and this leaflet with you. Other medicines and Pancrex V Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine as dose adjustments may be necessary. Driving and using machines Pancrex V does not interfere with your ability to drive or operate machinery. 3.
How to take it
Pancrex V
Dosage Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist have told you. Check with your doctor or pharmacist if you are not sure. Your doctor or pharmacist will advise you on the amount of Pancrex V to take before each meal, although you may find with experience that you need to adjust the dose according to the size and type of meal that you eat. If loose pale stools (faeces) occur you may need to increase the dose. For newborns, the contents of 1-2 capsules mixed with feeds should provide a good starting point for adjustment of the dose. If the capsule contents are mixed with liquids or feeds, use within one hour. If you take more Pancrex V than you should There are no special precautions to take. If you forget to take Pancrex V Simply skip that dose and take the next dose with your next meal or snack. Do not take a double dose to make up for a forgotten dose. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 4.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. Rarely, high levels of uric acid in the blood and urine have been reported when extremely high doses of pancreatin have been taken. Pan125mgCap-LPL-UK-6
Narrowing of parts of the bowel, and inflammation of the colon, have been reported in children with cystic fibrosis taking high doses of pancreatic enzyme supplements. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible
Possible side effects
not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine. 5.
How to store it
Pancrex V
Store in a refrigerator (2°C – 8°C). Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the label after EXP. The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment. 6.
Contents of the pack and other information
What Pancrex V contains The active substance is pancreatin. Each capsule contains at least: 160 BP units of free protease, an enzyme that digests protein 2950 BP units of lipase, an enzyme that digests fat 3300 BP units of amylase, an enzyme that digests starch and sugars BP is a British standard measure of potency (expected biological effect) of a pharmaceutical product. The other excipients are aluminium oxide, magnesium stearate and microcrystalline cellulose. The capsule is made of gelatin, which is of bovine origin. What Pancrex V looks like and contents of the pack Pancrex V consists of white or buff-coloured powder in a clear hard gelatin capsule. Each plastic container holds 300 or 500 capsules. However, not all pack sizes may be marketed. Marketing Authorisation Holder Essential Pharmaceuticals Ltd, 8a Crabtree Road, Egham, Surrey, TW20 8RN, UK. Manufacturer Lelypharma B.V., Zuiveringweg 42, 8243 PZ Lelystad, the Netherlands. This leaflet was last revised in 06/2024. Other sources of information
Pan125mgCap-LPL-UK-6
There are a number of websites available on your condition and its treatment, which may provide you with further useful information. Contact the Pancreatic Society of Great Britain and Ireland for assistance.
Pan125mgCap-LPL-UK-6
Frequently asked questions about Pancrex V 125 mg hard capsules
How do I take Pancrex V 125 mg hard capsules?
Pancrex V 125 mg hard capsules comes as capsule containing 125mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Pancrex V 125 mg hard capsules?
The active substance in Pancrex V 125 mg hard capsules is pancreatin.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Pancrex V 125 mg hard capsules, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Pancrex V 125 mg hard capsules without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: pancreatin
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
Pancrex V is used to compensate for reduced intestinal enzyme activity in pancreatic deficiency states.
It is indicated for the treatment of fibrocystic disease of the pancreas (cystic fibrosis), chronic pancreatitis and pancreatic steatorrhoea following pancreatectomy. It may also be indicated following gastrectomy as an aid to digestion.
4.2. Posology and method of administration
Posology
These low dose capsules may be used when small amounts of Pancrex V are required, for example for neonates.
Dosage should be adjusted according to the needs of the individual patient and the amount of food consumed.
The following dosage scale provides a suitable basis for adjustment.
Paediatric population
Neonates: The contents of 1-2 capsules mixed with feeds.
Method of administration
Oral use.
The capsules should be taken with each feed or before a meal.
If the capsule contents are mixed with liquids or feeds the resulting mixture should not be allowed to stand for more than one hour prior to use.
4.3. Contraindications
Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
4.4. Special warnings and precautions for use
It is possible that some irritation of the skin of the mouth may occur if capsules are chewed or the contents retained in the mouth. Irritation of the anus may also occur. A barrier cream may prevent this local irritation.
Allergic/asthmatic reactions have occasionally occurred on handling the capsule contents.
4.5. Interaction with other medicinal products and other forms of interaction
None known.
4.6. Fertility, pregnancy and lactation
Pancrex V should not be used in pregnancy and lactation unless clearly necessary but if required should be used in doses sufficient to provide adequate nutritional status.
4.7. Effects on ability to drive and use machines
Pancrex V has no or negligible influence on the ability to drive and use machines.
4.8. Undesirable effects
Rare cases of hyperuricosuria and hyperuricaemia have been reported when extremely high doses of pancreatin have been taken.
Strictures of the ileo-caecum and large bowel, and colitis, have been reported in children with cystic fibrosis taking high doses of pancreatic enzyme supplements. To date Pancrex and Pancrex V presentations have not been implicated in the development of colonic damage. However unusual abdominal symptoms or changes in abdominal symptoms should be reviewed to exclude the possibility of colonic damage especially if the patient is taking in excess of 10,000 units/kg/day of lipase.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellocard or search for MHRA Yellow Card in the Google Play or Apple App Store.
4.9. Overdose
None stated.
🇷🇴 Known in Romania as
Medicines sold in Romania with the same active substance: Cunoscut în România ca
- KREON 20000 over the counterPANCREATINUM · taken by mouth
- MEZYM 25000 over the counterPANCREATINUM · taken by mouth
- PANKREAL 35000 prescriptionPANCREATINUM · taken by mouth
- MEZYM 10000 over the counterPANCREATINUM · taken by mouth
- MEZYM 20000 over the counterPANCREATINUM · taken by mouth
- TRIFERMENT FORTE 325 mg over the counterPANCREATINUM · taken by mouth
Same active substance. The strength, the form and whether you need a prescription can differ. Always ask a pharmacist before you switch. Romanian medicines in the UK →
🇵🇱 Known in Poland as
Medicines sold in Poland with the same active substance: W Polsce znany jako
⚠ Same active substance, but a different pharmaceutical form (for example a gel instead of a tablet). Not interchangeable — ask a pharmacist.
- Kreon 25 000Pancreatinum
- Lipancrea 16 000Pancreatinum
- Lipancrea 8000Pancreatinum
- Pangrol 10 000Pancreatinum
- Neo-Pancreatinum FortePancreatinum
- Pangrol 25 000Pancreatinum
Same active substance. The strength, the form and whether you need a prescription can differ. Always ask a pharmacist before you switch. Polish medicines in the UK →
💬 Ask about this leaflet
Ask anything about Pancrex V 125 mg hard capsules. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.