Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Creon 10000 Capsules
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Pancreatin may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
How to take it
Creon 10000
- Swallow the capsules whole or
- Open the capsules and mix the granules (without crushing) with acidic liquid (e.g. apple, orange or pineapple juice) or soft food (e.g. apple sauce or yoghurt). Swallow the mixture straight away, without chewing.
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Pharmacode >>>
FRONT Date: 25-OCT-2025
Description Creon, 10000 IU, 100 Component Type Leaflet (Insert) Affiliate Item Code 3920825 Superseded Affiliate Item Code ART-334-05 TrackWise Job No. 3920825 MA No. PL 46302/0028
Site Barcode/ DataMatrix
1186
Viatris SAP No. 400541488 Vendor Job No. N/A Artwork Proof No. 3
Client Market United Kingdom
Supplier SAP No. N/A
Market Barcode Info N/A
New Supplier Code 1142606
3D Render ID N/A
Superseded Supplier Code 1140678
GTIN/PC N/A Packing Site/Printer Abbott Laboratories GmbH (Neustadt – DE) Notes N/A N/A Sign-offs
Time: 12:15
No. of colours 3 Colours Non-Print Colours
Page Count Black
P. 347 U
1 of 2
P. 3025 U
Keyline
Equate CMYK with Main Font Helvetica Neue LT Pro
Body Text Size 8 pt
Dimensions 300 x 141 mm
Min Text Size used 8 pt
Keyline/Drawing No. N/A
V6 APR 2025
<<< Pharmacode
- Drink plenty of liquid every day.
- Mixing with non-acidic food or liquid, crushing or chewing of the pellets may cause irritation in your mouth or change the way Creon works in your body.
- Do not hold Creon capsules or its content in your mouth.
- Do not store the mixture. How long to take Creon 10000 for You should take your medicine until your doctor tells you to stop. Many patients will need to take pancreatic enzyme supplements for the rest of their lives. If you take too much Creon 10000 If you take too much Creon 10000 you should drink plenty of water and see your doctor immediately. If you forget a dose If you forget to take your medicine, wait until your next meal and take your usual number of capsules. Do not try to make up for the number of capsules that you have missed. Just take your next dose at the usual time.
4. Possible side effects Like all medicines, Creon 10000 can cause side effects (unwanted effects or reactions), but not everyone gets them. If you have severe or long-lasting abdominal pain, contact your doctor immediately. If you notice any unusual abdominal symptoms while taking Creon 10000 – contact your doctor.
Very common side effects (affect more than 1 in 10 patients):
- stomach pains Common side effects (affect 1-10 patients out of 100):
- diarrhoea
- constipation
- feeling or being sick
- bloating Uncommon side effects (affect 1-10 patients out of 1000):
- Skin reactions, such as a rash.
By reporting side effects you can help provide more information on the safety of this medicine.
Possible side effects
not listed in this leaflet. You can also report side effects directly via the national reporting system listed below. In the UK: The Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store
Pharmacode >>>
Each capsule contains enteric coated brownishcoloured granules (minimicrospheres) containing pancreatin 150 mg, equivalent to: List of Enzymes: (PhEur units per capsule) Lipase 10,000 Amylase 8,000 Protease 600 3920825 1142606
BACK Date: 25-OCT-2025
Description Creon, 10000 IU, 100 Component Type Leaflet (Insert) Affiliate Item Code 3920825 Superseded Affiliate Item Code ART-334-05 TrackWise Job No. 3920825 MA No. PL 46302/0028
Site Barcode/ DataMatrix
1186
Viatris SAP No. 400541488 Vendor Job No. N/A Artwork Proof No. 3
Client Market United Kingdom
Supplier SAP No. N/A
Market Barcode Info N/A
New Supplier Code 1142606
3D Render ID N/A
Superseded Supplier Code 1140678
GTIN/PC N/A Packing Site/Printer Abbott Laboratories GmbH (Neustadt – DE) Notes N/A N/A Sign-offs
Time: 12:15
No. of colours 3 Colours Non-Print Colours
Page Count Black
P. 347 U
2 of 2
P. 3025 U
Keyline
Equate CMYK with Main Font Helvetica Neue LT Pro
Body Text Size 8 pt
Dimensions 300 x 141 mm
Min Text Size used 8 pt
Keyline/Drawing No. N/A
V6 APR 2025
How to store it
Creon 10000 How and where to keep your capsules Keep this medicine out of the sight and reach of children. Do not store above 25°C and keep in the original container. After opening do not store above 25 °C and use within 6 months. Keep the container tightly closed. The enzymes in Creon 10000 are natural products and their ability to digest food decreases over time. If the container is left in warm conditions (e.g. the glove compartment of a car), the digestive activity decreases faster.
The granules are coated with a mixture of the following ingredients: macrogol 4000, hypromellose phthalate, dimeticone, triethyl citrate and cetyl alcohol. The capsules contain: gelatin, iron oxides (E172) and sodium lauryl sulfate. Creon 10000 is available in 100, 250 or 300 capsule packs. Not all pack sizes may be marketed. The Marketing Authorisation Holder is: Viatris Products Limited, Station Close, Potters Bar, EN6 1TL, United Kingdom.
During use, some patients have also experienced the following, the frequency of which is unknown:
- itching with or without a rash
- allergic reactions (which may be severe)
- severe or long-lasting abdominal pain (Fibrosing colonopathy).
Do not take Creon 10000 capsules after the expiry date on the bottle.
The Manufacturer is: Abbott Laboratories GmbH, 31535 Neustadt a. Rbge, Germany.
Return all unused medicine to your pharmacist.
® Registered trademark
At extremely high doses, some patients have had high levels of uric acid in their blood and urine.
6. Further information
If you wish to receive this PIL in Braille, large font or audio format please contact 023 8046 7000.
The ingredients in Creon 10000 The active ingredient in Creon 10000 is pancreatin.
This leaflet was last revised in October 2025
Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible
Frequently asked questions about Creon 10000 Capsules
How do I take Creon 10000 Capsules?
Creon 10000 Capsules comes as capsule. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Creon 10000 Capsules?
The active substance in Creon 10000 Capsules is pancreatin.
Are there equivalent medicines to Creon 10000 Capsules?
Medicines with the same active substance, strength and form include: Creon 25000 Capsules. They are interchangeable only if your prescriber or pharmacist says so.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Creon 10000 Capsules, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Creon 10000 Capsules without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: pancreatin
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
For the treatment of pancreatic exocrine insufficiency.
4.2. Posology and method of administration
Adults (including the elderly) and children:
Initially one or two capsules during or immediately after each meal. Dose increases, if required, should be added slowly, with careful monitoring of response and symptomatology.
The capsules can be swallowed whole, or for ease of administration they may be opened and the granules taken with acidic fluid or soft food, but without chewing.
This could be apple sauce or yoghurt or any fruit juice with a pH less than 5.5, e.g. apple, orange or pineapple juice. If the granules are mixed with fluid or food it is important that they are taken immediately and the mixture not stored, otherwise dissolution of the enteric coating may result. In order to protect the enteric coating, it is important that the granules are not crushed or chewed. Crushing and chewing of the minimicrospheres or mixing with food or fluid with a pH greater than 5.5 can disrupt the protective enteric coating. This can result in early release of enzymes in the oral cavity and may lead to reduced efficacy and irritation of the mucous membranes. Care should be taken to ensure that no product is retained in the mouth.
It is important to ensure adequate hydration of patients at all times whilst dosing Creon.
Fibrosing colonopathy has been reported in patients with cystic fibrosis taking in excess of 10,000 units of lipase/kg/day (see section 4.4).
4.3. Contraindications
Hypersensitivity to pancreatin of porcine origin or to any of the excipients.
4.4. Special warnings and precautions for use
Strictures of the ileo-caecum and large bowel (fibrosing colonopathy) have been reported in patients with cystic fibrosis taking high doses of pancreatin preparations. As a precaution, unusual abdominal symptoms or changes in abdominal symptoms should be medically assessed to exclude the possibility of fibrosing colonopathy, especially if the patient is taking in excess of 10,000 units of lipase/kg/day.
Creon is essentially 'sodium free' as it contains less than 1 mmol sodium (23 mg) per dose (2 mg).
Traceability
In order to improve the traceability of biological medicinal products, the name and the batch number of the administered product should be clearly recorded.
4.5. Interaction with other medicinal products and other forms of interaction
No interaction studies have been performed.
4.6. Pregnancy and lactation
PregnancyFor pancreatic enzymes no clinical data on exposed pregnancies are available.Animal studies show no evidence for any absorption of porcine pancreatic enzymes. Therefore, no reproductive or developmental toxicity is to be expected.Caution should be exercised when prescribing to pregnant women.LactationNo effects on the suckling child are anticipated since animal studies suggest no systemic exposure of the breast-feeding woman to pancreatic enzymes. Pancreatic enzymes can be used during breast-feeding.
If required during pregnancy or lactation Creon should be used in doses sufficient to provide adequate nutritional status.
4.7. Effects on ability to drive and use machines
Creon has no or negligible influence on the ability to drive or use machines.
4.8. Undesirable effects
In clinical trials, more than 900 patients were exposed to Creon. The most commonly reported adverse reactions were gastrointestinal disorders and were primarily mild or moderate in severity.
The following adverse reactions have been observed during clinical trials with the below indicated frequencies;
Organ system
Very common
≥ 1/10
Common
≥ 1/100 to < 1/10
Uncommon
≥ 1/1000 to < 1/100
Frequency not known
Gastrointestinal disorders
abdominal pain*
nausea, vomiting, constipation, abdominal distention, diarrhoea*
strictures of the ileo-caecum and large bowel
(fibrosing colonopathy)
Skin and subcutaneous tissue disorders
rash
pruritus, urticaria
Immune system disorders
hypersensitivity
(anaphylactic reactions).
*Gastrointestinal disorders are mainly associated with the underlying disease. Similar or lower incidences compared to placebo were reported for abdominal pain and diarrhoea.
Strictures of the ileo-caecum and large bowel (fibrosing colonopathy) have been reported in patients with cystic fibrosis taking high doses of pancreatin preparations, see section 4.4 Special warnings and precautions for use.
Allergic reactions mainly but not exclusively limited to the skin have been observed and identified as adverse reactions during post-approval use. Because these reactions were reported spontaneously from a population of uncertain size, it is not possible to reliably estimate their frequency.
Paediatric population
No specific adverse reactions were identified in the paediatric population. Frequency, type and severity of adverse reactions were similar in children with cystic fibrosis as compared to adults.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
4.9. Overdose
Extremely high doses of pancreatin have been reported to be associated with hyperuricosuria and hyperuricaemia.
Supportive measures including stopping enzyme therapy and ensuring adequate rehydration are recommended.
💬 Ask about this leaflet
Ask anything about Creon 10000 Capsules. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.