Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Mebeverine 200mg modified release capsules
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Mebeverine hydrochloride may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
What it is and what it is used for
for This medicine is a capsule containing Mebeverine hydrochloride, which belongs to a group of medicines called antispasmodics. This medicine is used to treat the symptoms of irritable bowel syndrome (IBS). This is a very common condition which causes spasm and pain in the gut or intestine. The intestine is a long muscular tube which food passes down so it can be digested. If the intestine goes into spasm and squeezes too tightly, you get pain. The way this medicine works is by relieving the spasm, pain and other symptoms of IBS. The main symptoms of irritable bowel syndrome (IBS) include:
- stomach pain and spasm
- feeling bloated and having wind
- having diarrhoea (with or without constipation)
- small, hard, pellet-like or ribbon-like stools (faeces) These symptoms may vary from person to person. Talk to your doctor or pharmacist if these symptoms do not improve after a while, if you develop new symptoms, or you are concerned about your symptoms. Your diet and lifestyle can also help to treat IBS: How you restrict your diet depends on the way IBS affects you. If you find that certain foods bring on the symptoms, then it makes sense not to eat them. A high fibre diet may help, but ask your doctor or pharmacist for more information. Some people find that learning to relax can help to lessen their symptoms of IBS. You may find it helpful to set aside a few moments each day to relax and gently unwind.
What you need to know before you take it
e Mebeverine Do not take Mebeverine:
- if you are allergic to mebeverine hydrochloride or any of the other ingredients of this medicine (listed in section 6). If the above applies to you, do not take this medicine and talk to your doctor or pharmacist. Warnings and precautions Talk to your doctor or pharmacist before taking Mebeverine:
- if you have developed new symptoms or your symptoms have become worse.
- if you have liver or kidney problems. Children and adolescents This medicine is not recommended for use in children and adolescents below 18 years old. Other medicines and Mebeverine Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Mebeverine with alcohol You can drink alcohol while you are taking Mebeverine. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Pregnancy There is only limited information about the safety of Mebeverine for pregnant women. Your doctor may advise you to stop taking Mebeverine before you become pregnant or as soon as you know you are pregnant. Breast-feeding Mebeverine should not be used during breast-feeding. Driving and using machines This medicine is not likely to affect you being able to drive or use any tools or machines. Mebeverine contains Sucrose If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking the medicinal product.
How to take it
Mebeverine Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
- Try to take the capsule 20 minutes before a meal – some people find their symptoms to be strongest after they have eaten.
- Swallow the capsule whole with a drink of water. Do not chew the capsule. Adults (including the elderly)
- The recommended starting dose is one capsule twice a day. If you take more Mebeverine than you should If you or someone else takes too much Mebeverine (an overdose), talk to a doctor or go to a hospital straight away. Take the medicine pack with you. If you forget to take Mebeverine If you miss a capsule, take it when you remember. However, if it is nearly time for the next dose, skip the missed dose and carry on as normal with the next dose. Do not take a double dose to make up for a forgotten dose. If you stop taking Mebeverine Do not stop taking Mebeverine without talking to your doctor, even if you feel better. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. If you get any of these serious side effects, stop taking the capsules. See a doctor at once:
- Difficulty in breathing, swelling of face, neck, tongue or throat (severe allergic reactions). These other effects are less serious. If they bother you talk to a pharmacist:
- skin rash, red itchy skin Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via The Yellow Card Scheme (website: www.mhra.gov.uk/ yellowcard). By reporting side effects you can help provide more information on the safety of this medicine.
How to store it
Mebeverine Keep out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister pack. The expiry date refers to the last day of that month. Store Mebeverine in the original package. Store below 30°C. Return any unused capsules to a pharmacist. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Contents of the pack and other information
What Mebeverine contains The active substance is mebeverine hydrochloride. Each capsule contains 200mg of mebeverine hydrochloride in a modified release formulation. The other ingredients are: Capsule core Sugar spheres (sucrose, maize) Povidone Hypromellose Capsule Coating Ethyl cellulose N-45 Macrogol 6000 Magnesium stearate Capsule Shell Gelatin Titanium dioxide (E171) What Mebeverine looks like and the contents of the pack Mebeverine comes as creamy white hard capsules, filled with white to off white coloured spherical pellets. Packs may contain 10, 30 or 60 capsules. Not all pack sizes may be marketed. Marketing Authorisation Holder and Manufacturer Aspire Pharma Limited Unit 4, Rotherbrook Court, Bedford Road, Petersfield Hampshire, GU32 3QG, United Kingdom Alternative Manufacturer Wave Pharma Limited Ground Floor, Cavendish House, 369 Burnt Oak Broadway Edgware, HA8 5AW, United Kingdom This leaflet was last revised in 01/2023.
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Frequently asked questions about Mebeverine 200mg modified release capsules
How do I take Mebeverine 200mg modified release capsules?
Mebeverine 200mg modified release capsules comes as capsule containing 200mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Mebeverine 200mg modified release capsules?
The active substance in Mebeverine 200mg modified release capsules is mebeverine hydrochloride.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Mebeverine 200mg modified release capsules, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Mebeverine 200mg modified release capsules without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: mebeverine hydrochloride
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
For the symptomatic relief of irritable bowel syndrome.
4.2. Posology and method of administration
Posology
One capsule of 200 mg twice daily, to be given one in the morning and one in the evening.
Paediatric Population
Mebeverine 200 mg modified release capsules are not recommended for use in children and adolescents below 18, due to insufficient data on safety and efficacy.
Duration of use is not limited.
If one or more doses are missed, the patient should continue with the next dose as prescribed; the missed dose(s) should not be taken in addition to the regular dose.
Special Population
No posology studies in elderly, renal and/or hepatic impaired patients have been performed. No specific risk for elderly, renal and/or hepatic impaired patients could be identified from available post-marketing data. No dosage adjustment is deemed necessary in elderly, renal and/or hepatic impaired patients.
Method of administration
Adults (including the elderly):
The capsules should be swallowed with a sufficient amount of water (at least 100 ml water). They should not be chewed because the coating is intended to ensure a prolonged release mechanism (see 5.2).
4.3. Contraindications
Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
4.4. Special warnings and precautions for use
Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltese insufficiency should not take this medicine.
4.5. Interaction with other medicinal products and other forms of interaction
No interaction studies have been performed, except with alcohol. In vitro and in vivo studies in animals have demonstrated the absence of any interaction between mebeverine hydrochloride and ethanol.
4.6. Fertility, pregnancy and lactation
Pregnancy
There are no or limited amounts of data from the use of mebeverine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity (see section 5.3). Mebeverine is not recommended during pregnancy.
Breastfeeding
It is unknown whether mebeverine or its metabolites are excreted in human milk. The excretion of mebeverine in milk has not been studied in animals.
Mebeverine should not be used during breast-feeding.
Fertility
There are no clinical data on male or female fertility; however, animal studies do not indicate harmful effects of mebeverine (see section 5.3).
4.7. Effects on ability to drive and use machines
No studies on the effects on the ability to drive and use machines have been performed. The pharmacodynamic and pharmacokinetic profile as well as postmarketing experience do not indicate any harmful effect of mebeverine on the ability to drive or to use machines.
4.8. Undesirable effects
The following adverse reactions have been reported spontaneously during postmarketing use. A precise frequency cannot be estimated from available data.
Allergic reactions mainly but not exclusively limited to the skin have been observed.
Immune system disorders:
Hypersensitivity (anaphylactic reactions)
Skin and subcutaneous tissue disorders:
Urticaria, angioedema, face oedema, exanthema.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
4.9. Overdose
Theoretically CNS excitability may occur in cases of overdose. In cases where mebeverine was taken in overdose, symptoms were either absent or mild and usually rapidly reversible. Observed symptoms of overdose were of a neurological and cardiovascular nature.
No specific antidote is known and symptomatic treatment is recommended.
Gastric lavage should only be considered in case of multiple intoxication or if discovered within about one hour. Absorption reducing measures are not necessary.
🇷🇴 Known in Romania as
Medicines sold in Romania with the same active substance: Cunoscut în România ca
- DUSPATALIN 200 mg prescriptionMEBEVERINUM · taken by mouth
- COLOSPASMIN 100 mg drajeuri prescriptionMEBEVERINUM · taken by mouth
Same active substance. The strength, the form and whether you need a prescription can differ. Always ask a pharmacist before you switch. Romanian medicines in the UK →
🇵🇱 Known in Poland as
Medicines sold in Poland with the same active substance: W Polsce znany jako
- Duspatalin GastroMebeverini hydrochloridum · taken by mouth
Same active substance. The strength, the form and whether you need a prescription can differ. Always ask a pharmacist before you switch. Polish medicines in the UK →
💬 Ask about this leaflet
Ask anything about Mebeverine 200mg modified release capsules. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.