Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Mebeverine 135mg film-coated tablets
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Mebeverine hydrochloride may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
What it is and what it is used for
for Mebeverine 135 mg film-coated tablets contain the active ingredient mebeverine hydrochloride. This belongs to a group of medicines called antispasmodics. Mebeverine helps to relax the muscles of the gastro-intestinal tract (gut). It is used in conditions such as irritable bowel syndrome and similar problems such as chronic irritable colon, spastic constipation, mucous colitis and spastic colitis. Irritable bowel syndrome (IBS) is a very common condition which causes spasm and pain in the gut or intestine. The intestine is a long muscular tube which food passes down so it can be digested. If the intestine goes into spasm and squeezes too tightly, you get pain. The way this medicine works is by relieving the spasm, pain and other symptoms of IBS. The main symptoms of irritable bowel syndrome (IBS) include:
- stomach pain and spasm
- persistent diarrhoea, or alternating constipation and diarrhoea
- flatulence (wind) and feeling bloated
- small, hard, pellet-like or ribbon-like stools (faeces) These symptoms may vary from person to person.
Black
A/s: 190 x 210 mm
Your diet and lifestyle can also help treat IBS: How you restrict your diet depends on the way IBS affects you. If you find that certain foods bring on the symptoms, then it makes sense not to eat them. A high fibre diet may help, but ask your pharmacist for more information. Some people find that learning to relax can help to lessen their symptoms of IBS. You may find it helpful to set aside a few moments each day to relax and gently unwind.
What you need to know before you take it
e Mebeverine Do not take Mebeverine: If you are allergic to mebeverine or to any of the other ingredients of this medicine (listed in section 6). Warnings and precautions Talk to your doctor or pharmacist before taking Mebeverine if:
- You have developed new symptoms or your symptoms have become worse.
- You have liver or kidney problems If the above applies to you (or you are not sure), talk to your doctor or pharmacist before taking this medicine. Other medicines and Mebeverine Mebeverine is not known to interact with other medicines but you should tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Mebeverine with alcohol You can drink alcohol while you are taking Mebeverine 135 mg film-coated tablets. Pregnancy, breastfeeding and fertility If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. There is only limited information about the safety of Mebeverine for pregnant women. Your doctor may advise you to stop taking Mebeverine before you become pregnant or as soon as you know you are pregnant. Mebeverine should not be used during breastfeeding. Driving and using machines Mebeverine are not likely to affect your ability to drive or use machines. Mebeverine contains lactose If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. Mebeverine contains sodium This medicine contains less than 1 mmol sodium (23 mg) per each film coated tablet, that is to say essentially 'sodium-free'.
P1540166
Package Leaflet: Information for the patient
Talk to your doctor if these symptoms do not improve after a while, if you develop new symptoms or you are concerned about your symptoms.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. If you notice the following stop taking the tablets and go to your doctor immediately, or your nearest hospital.
- Difficulty in breathing, swelling of the face, neck, lips, tongue or throat (severe allergic reactions) Other side effects: allergic reactions may occur, such as skin reactions, inflamed or reddened skin, swelling, hives, itching or skin rashes. If you get any side effects, talk to your doctor or pharmacist. This includes any side effects not listed in this leaflet. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.
Store this medicine in a dry place below 30°C and protect from light. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
How to store it
Mebeverine
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Keep this medicine out of the sight and reach of children.
Adults (including the elderly):
- The recommended dose is one tablet three times a day. Do not take more than three tablets per day.
- The number of tablets you take may be lowered if your symptoms improve. Children and adolescents: Mebeverine is not recommended for use in children and adolescents below 18 years of age. If you take more Mebeverine than you should If you or someone else take more Mebeverine Tablets than you should (overdose), contact your doctor or hospital emergency department immediately. Take this leaflet and any remaining tablets with you If you forget to take Mebeverine If you forget to take a dose of Mebeverine film-coated tablets at the right time, take it as soon as you remember, unless it is nearly time for your next dose. Do not take a double dose to make up for the forgotten tablet. If you stop taking Mebeverine Do not stop taking the tablets without talking to your doctor, even if you feel better. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Contents of the pack and other information
What Mebeverine contains The active substance is mebeverine hydrochloride. Each filmcoated tablet contains 135 mg mebeverine hydrochloride The other ingredients are: microcrystalline cellulose lactose monohydrate povidone talc magnesium stearate sodium starch glycollate. The tablet coating includes hydroxypropyl methylcellulose (E464), titanium dioxide (E171) and polyethylene glycol. What Mebeverine look like and contents of the pack Mebeverine tablets are white-coated tablets marked "MV135" on one side. The medicine is available in either plastic bottles or blister packs of 12, 15, 18, 20, 21, 28, 30, 56, 60, 84, 90 and 100 tablets. Not all pack sizes may be marketed. Marketing Authorisation Holder: Milpharm Limited 1 Roundwood Avenue Stockley Park, Uxbridge UB11 1AF United Kingdom Manufacturer: APL Swift Services (Malta) Ltd, HF26, Hal Far Industrial Estate, Hal Far, Birzebbugia, BBG 3000, Malta. Milpharm Limited 1 Roundwood Avenue Stockley Park, Uxbridge UB11 1AF United Kingdom This leaflet was last revised in 10/2025
P1540166
Try to take the tablet 20 minutes before a meal – some people find their symptoms to be strongest after they have eaten. Swallow the tablet whole with water. Do not chew the tablet.
Do not use this medicine after the expiry date which is stated on the carton or label after EXP. The expiry date refers to the last day of that month.
Frequently asked questions about Mebeverine 135mg film-coated tablets
How do I take Mebeverine 135mg film-coated tablets?
Mebeverine 135mg film-coated tablets comes as tablet containing 135mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Mebeverine 135mg film-coated tablets?
The active substance in Mebeverine 135mg film-coated tablets is mebeverine hydrochloride.
Are there equivalent medicines to Mebeverine 135mg film-coated tablets?
Medicines with the same active substance, strength and form include: Boots IBS Symptom Relief 135mg Tablets, Mebeverine hydrochloride 135 mg Film-coated Tablets, Mebeverine hydrochloride 135mg film-coated tablets. They are interchangeable only if your prescriber or pharmacist says so.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Mebeverine 135mg film-coated tablets, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Mebeverine 135mg film-coated tablets without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: mebeverine hydrochloride
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
For the symptomatic treatment of irritable bowel syndrome and other conditions usually included in this grouping such as: chronic irritable colon, spastic constipation, mucous colitis, spastic colitis. Mebeverine is effectively used to treat the symptoms of these conditions such as: colicky abdominal pain and cramps, persistent, non-specific diarrhoea (with or without alternating constipation) and flatulence.
4.2. Posology and method of administration
Posology
Duration of use is not limited.
If one or more doses are missed, the patient should continue with the next dose as prescribed; the missed dose(s) should not be taken in addition to the regular dose.
Adults (including the elderly):
One tablet three times a day, preferably 20 minutes before meals. After a period of several weeks, when the desired effect has been obtained, the dosage may be gradually reduced.
Paediatric population:
Mebeverine 135 mg film-coated tablets are not recommended for use in children and adolescents below 18 years, due to insufficient data on safety and efficacy.
Special population:
No posology studies in elderly, renal and/or hepatic impaired patients have been performed. No specific risk for elderly, renal and/or hepatic impaired patients could be identified from available post-marketing data. No dosage adjustment is deemed necessary in elderly, renal and/or hepatic impaired patients.
Method of administration
For oral use.
The film-coated tablets should be swallowed with a sufficient amount of water (at least 100 ml water). Tablets should not be chewed because of the unpleasant taste.
4.3. Contraindications
Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
4.4. Special warnings and precautions for use
If this is the first time you have had these symptoms talk to your doctor before using this medicine. This is to make sure it is suitable for you.
Do not use this medicine without talking to your doctor if you:
- are over 40 years of age
- have passed blood in your stools or motions
- are feeling sick or being sick
- have lost your appetite or lost weight
- look pale and feel tired
- are very constipated
- have a fever
- have recently travelled abroad
- are or may be pregnant
- have abnormal vaginal bleeding or discharge
- have difficulty or pain passing water
Talk to your doctor if you get new symptoms, your symptoms get worse or if they do not improve after 2 weeks of treatment.
Excipients:
Mebeverine contains lactose
Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Mebeverine contains sodium
This medicine contains less than 1 mmol sodium (23 mg) per each hard capsule, that is to say essentially 'sodium-free'.
4.5. Interaction with other medicinal products and other forms of interaction
No interaction studies have been performed, except with alcohol. In vitro and in vivo studies in animals have demonstrated the absence of any interaction between mebeverine hydrochloride and ethanol.
4.6. Fertility, pregnancy and lactation
Pregnancy
There are no or limited amounts of data from the use of mebeverine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity (see section 5.3). Mebeverine is not recommended during pregnancy.
Breast-feeding
It is unknown whether mebeverine or its metabolites are excreted in human milk. The excretion of mebeverine in milk has not been studied in animals. Mebeverine should not be used during breast‑feeding.
Fertility
There are no clinical data on male or female fertility; however, animal studies do not indicate harmful effects of mebeverine (see section 5.3).
4.7. Effects on ability to drive and use machines
No known studies on the effects on the ability to drive and use machines have been performed. The pharmacodynamic and pharmacokinetic profile as well as postmarketing experience do not indicate any harmful effect of mebeverine on the ability to drive or to use machines.
4.8. Undesirable effects
The following adverse reactions have been reported spontaneously during postmarketing use. A precise frequency cannot be estimated from available data.
Allergic reactions mainly but not exclusively limited to the skin have been reported.
Immune system disorders:
Hypersensitivity (anaphylactic reactions)
Skin and subcutaneous tissue disorders:
Urticaria, angioedema, face oedema and exanthema.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
4.9. Overdose
Theoretically CNS excitability may occur in cases of overdose. In cases where mebeverine was taken in overdose, symptoms were either absent or mild and usually rapidly reversible. Observed symptoms of overdose were of a neurological and cardiovascular nature.
No specific antidote is known and symptomatic treatment is recommended.
Gastric lavage should only be considered in case of multiple intoxication or if discovered within about one hour. Absorption reducing measures are not necessary.
💬 Ask about this leaflet
Ask anything about Mebeverine 135mg film-coated tablets. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.