Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official and paediatric dosages, pregnancy and breastfeeding guidance, and NHS pharmacy opening hours — all in one place.

Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official and paediatric dosages, pregnancy and breastfeeding guidance, and NHS pharmacy opening hours — all in one place.

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Amoxicillin 1g, powder for solution for injection/ infusion

What it is and what it is used for

Amoxicillin contains the active ingredient amoxicillin which is an antibiotic. This belongs to a group of medicines called 'penicillins'.

What Amoxicillin is used for « to treat infections caused by bacteria in different parts of the body.

- for urgent treatment of severe infection or if patients cannot take amoxicillin by mouth.

What you need to know before you take it

You must not be given Amoxicillin - if you are allergic to amoxicillin or penicillin

- if you have ever had an allergic reaction to any antibiotic. This can include a skin rash or swelling of the face or throat you must not be given Amoxicillin if any of the above apply.

If you are not sure, talk to your doctor, pharmacist or nurse before you are given this medicine.

Warnings and precautions Talk to your doctor, pharmacist or nurse before you are given Amoxicillin:

- if you have glandular fever (fever, sore throat, swollen glands and extreme tiredness) - if you have kidney problems - if you are not urinating regularly (pass water)

If you are not sure if any of the above apply to you, talk to your doctor, pharmacist or nurse before you are given Amoxicillin.

Blood and urine tests

If you are having:

+ urine tests (glucose) or blood tests for liver function

+ oestriol tests (used during pregnancy to check the baby is developing normally)

Tell your doctor, pharmacist or nurse that you are being given Amoxicillin. This is because Amoxicillin can affect the results of these tests.

This medicine contains sodium. This medicinal product contains 2.74 mmol (or 63 mg) sodium per vial. To be taken into account in patients controlling their dietary sodium intake.

Other medicines and Amoxicillin

Tell the doctor, pharmacist or nurse if you are taking, have recently taken or might take any

other medicines:

- allopurinol (used for gout), as it may be more likely that you will have an allergic skin reaction if you are taking it while being given Amoxicillin

« probenecid (used to treat gout), concomitant use of probenecid may reduce the excretion of amoxicillin and is not recommended.

« medicines to help stop blood clots (such as warfarin), as you may need extra blood tests

¢ other antibiotics (such as tetracycline), as Amoxicillin may be less effective

methotrexate (used to treat cancer and severe psoriasis), penicillins may reduce the

excretion of methotrexate causing a potential increase in side effects.

Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you are given this medicine.

Driving and using machines

Amoxicillin can have side effects and the symptoms (such as allergic reactions, dizziness and fits) may make you unfit to drive.

Do not drive or operate machinery unless you are feeling well.

Amoxicillin contains sodium This medicine contains approximately 63 mg sodium per vial.

This medicinal product contains 63 mg sodium per dose of 1g, equivalent to 3.2% of the WHO recommended maximum daily intake of 2 g sodium an adult.

How to take it

You will never give yourself this medicine. A qualified person, like a doctor or a nurse, will

give you this medicine.

« Amoxicillin will be given as an injection or an infusion into a vein (intravenously) or muscle (intramuscularly).

- Your doctor will decide how much you need each day and how often the injections should be given.

« Make sure you drink plenty of fluids while you are being treated with Amoxicillin.

The recommended doses are as follows

¢ Children up to 40 kg - Most infections: 20 mg to 200 mg for every kilogram of body weight in divided doses throughout the day - Lyme disease (an infection spread by parasites called ticks): isolated erythema migrans (early stage — red or pink circular rash) 25 mg to 50 mg for every kilogram of body weight in divided doses throughout the day; systemic manifestations (late stage — for more serious symptoms or when the disease spreads around your body) 100 mg for every kilogram of body weight in divided doses throughout the day Intravenous maximum single dose: 50 mg for every kilogram of body weight. Intramuscular maximum daily dose: 120 mg for every kilogram of body weight as 2 to 6 equally divided doses.

e Adults, elderly patients and children weighing 40 kg or more

- Recommended daily dosage: 750 mg to 6 g administered in divided doses - Lyme disease (an infection spread by parasites called ticks): isolated erythema migrans (early stage — red or pink circular rash) 4 g per day; systemic manifestations (late stage — for more serious symptoms or when the disease spreads around your body) 6 g per day Intravenous maximum daily dose: 12 g per day. Intravenous maximum single dose: 2 g by infusion or | g by bolus injection. Intramuscular maximum daily dose: 4 g per day. Intramuscular maximum single dose: | g.

¢ Use in patients with kidney problems If you have kidney problems the dose might be lower than the usual dose

How long will you be given Amoxicillin for?

« You will not normally be given Amoxicillin for more than 2 weeks without the doctor reviewing your treatment.

- If you use Amoxicillin for a long time you can develop thrush (a yeast infection of moist areas of the body which can cause soreness, itching and white discharge). If this occurs, tell your doctor, pharmacist or nurse.

- If you are given Amoxicillin for a long time, your doctor may perform additional tests to check your kidneys, liver and blood are working normally.

If you are given more Amoxicillin than recommended

It is unlikely you will be given too much, but if you think you have been given too much Amoxicillin , tell your doctor, pharmacist or nurse immediately. Signs might be an upset stomach (feeling sick, being sick or diarrhoea) or crystals in the urine, which may be seen as cloudy urine or problems urinating.

If you think you have missed an injection Speak to your doctor, pharmacist or nurse.

If you have any further questions about how this product is given, ask your doctor, pharmacist or nurse.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Talk to a doctor or nurse straight away if you notice any of the following very rare serious side effects — you may need urgent medical treatment.

Very rare (may affect up to 1 in 10,000 people) allergic reactions, the signs may include: skin itching or rash, swelling of the face, lips, tongue, body or breathing difficulties. These can be serious and occasionally deaths have occurred rash or pinpoint flat red round spots under the skin surface or bruising of the skin. This is due to inflammation of blood vessel walls due to an allergic reaction. It can be associated with joint pain (arthritis) and kidney problems a delayed allergic reaction can occur usually 7 to 12 days after having Amoxicillin, some signs include: rashes, fever, joint pains and enlargement of the lymph nodes especially under the arms. a skin reaction known as 'erythema multiforme' where you may develop: itchy reddish purple patches on the skin especially on the palms of the hands or soles of the feet, 'hivelike' raised swollen areas on the skin, tender areas on the surfaces of the mouth, eyes and genitals. You may have a fever and be very tired. other severe skin reactions can include: changes in skin colour, bumps under the skin, blistering, pustules, peeling, redness, pain, itching, scaling. These may be associated with fever, headaches and body aches. flu-like symptoms with a rash, fever, swollen glands, and abnormal blood test results (including increased white blood cells (eosinophilia) and liver enzymes) (Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)) fever, chills, a sore throat or other signs of an infection, or if you bruise easily. These may be signs of a problem with your blood cells. the Jarisch-Herxheimer reaction which occurs during treatment with Amoxicillin for Lyme disease and causes fever, chills, headache, muscle pain and skin rash inflammation of the large bowel (colon) with diarrhoea (sometimes containing blood), pain and fever serious liver side effects may occur. They are mainly associated with people having treatment over a long period, males and the elderly. You must tell your doctor urgently if you get:

severe diarrhoea with bleeding

blisters, redness or bruising of the skin

darker urine or paler stools

yellowing of the skin or the whites of the eyes (jaundice). See also anaemia below

which might result in jaundice.

These serious side effects can happen when you are being given the medicine or for up to several weeks after.

If any of the above occurs, talk to your doctor or nurse straight away.

Sometimes you may get less severe skin reactions such as: « amildly itchy rash (round, pink-red patches), "hive-like' swollen areas on forearms, legs, palms, hands or feet. This is uncommon (may affect up to | in 100 people).

If you have any of these talk to your doctor or nurse as Amoxicillin will need to be stopped.

Other possible side effects:

Common (may affect up to | in 10 people) ¢ skin rash

« feeling sick (nausea)

« diarrhoea

Uncommon (may affect up to 1 in 100 people) - being sick (vomiting)

Very rare (may affect up to 1 in 10,000 people)

- thrush (a yeast infection of the vagina, mouth or skin folds); you can get treatment for thrush from your doctor, pharmacist or nurse

« kidney problems

+ fits (convulsions), see in patients on high doses or with kidneys problems

+ dizziness

« hyperactivity

- crystals in the urine leading to acute renal injury, which may be seen as cloudy urine, or difficulty or discomfort in passing urine make sure you drink plenty of fluids to reduce the chance of these symptoms

« an excessive breakdown of red blood cells causing a type of anaemia. Signs include: tiredness, headaches, shortness of breath, dizziness, looking pale and yellowing of the skin and the whites of the eyes

« low number of white blood cells

¢ low number of cells involved with blood clotting the blood may take longer to clot than it normally would. You may notice this if you have a nosebleed or cut yourself

« Inflammation of the protective membrane surrounding the brain (aseptic meningitis)

Not known: Chest pain in the context of allergic reactions, which may be a symptom of allergy triggered cardiac infarction (Kounis syndrome)

Drug-induced enterocolitis syndrome (DIES): DIES has been reported mainly in children receiving amoxicillin. It is a certain kind of allergic reaction with the leading symptom of repetitive vomiting (1-4 hours after drug administration). Further symptoms could comprise abdominal pain, lethargy, diarrhoea, and low blood pressure.

Rash with blisters arranged in a circle with central crusting or like a string of pearls (linear IgA disease)

Inflammation of the membranes that surround the brain and spinal cord (aseptic meningitis)

Reporting of side effects

If you get any side effects, talk to your doctor, nurse, or pharmacist. This includes any possible side effects not listed in this leaflet.

You can also report side effects directly via the Yellow Card Scheme at: www.ihra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

How to store Amoxicillin Amoxicillin is for use in hospital only.

The expiry date and storage instructions stated on the label are for the doctor, pharmacist or nurse's information.

The doctor, pharmacist or nurse will make up your medicine.

Contents of the pack and other information

What Amoxicillin contains

¢ The active substance in each vial is | g amoxicillin.

¢ There are no other ingredients. However, the doctor, nurse or pharmacist will prepare the injection before use, using an appropriate fluid (such as water for injection or an injection/infusion fluid). See section 2 for information about sodium in this medicine.

What Amoxicillin looks like and contents of the pack

Amoxicillin is a white or almost white powder filled into a glass vial.

Vials containing 1g of amoxicillin sodium for injection are packaged in single packs or in packs of 10.

Marketing Authorisation Holder PANPHARMA

Z.I. du Clairay

35133 Luitré

France

Manufacturer PANPHARMA Z.1. du Clairay 35133 Luitré France

This leaflet was last revised in April 2025.

General advice regarding the use of antibiotics

Antibiotics are used to treat infections caused by bacteria. They have no effect against infections caused by viruses.

Sometimes an infection caused by bacteria does not respond to a course of an antibiotic. One of the commonest reasons for this to occur is because the bacteria causing the infection are resistant to the antibiotic that is being taken. This means that they can survive and even multiply despite the antibiotic.

Bacteria can become resistant to antibiotics for many reasons. Using antibiotics carefully can help to reduce the chance of bacteria becoming resistant to them.

When your doctor prescribes a course of an antibiotic it is intended to treat only your current illness. Paying attention to the following advice will help prevent the emergence of resistant bacteria that could stop the antibiotic working.

1. It is very important that you take the antibiotic at the right dose, at the right times and for the right number of days. Read the instructions on the label and if you do not understand anything ask your doctor or pharmacist to explain.

2. You should not take an antibiotic unless it has been prescribed specifically for you and you should use it only to treat the infection for which it was prescribed.

3. You should not take antibiotics that have been prescribed for other people even if they had an infection that was similar to yours.

4. You should not give antibiotics that were prescribed for you to other people.

5. If you have any antibiotic left over when you have taken the course as directed by your doctor you should take the remainder to a pharmacy for appropriate disposal.

The following information is intended for medical or healthcare professionals only:

Please refer to the Summary of Product Characteristics for further information.

Intravenous administration

Vial Diluent (mL) lg 20

Water for injection is the normal diluent. Administer within 30 minutes of reconstitution.

All solutions should be shaken vigorously before injection.

Any residual antibiotic solution should be discarded. For single use only

Preparation of intravenous infusions and stability 1 g: add without delay the reconstituted solution of 1 g (as prepared above - these are minimum volumes) to 100 mL infusion fluid (e.g. using a mini bag or in-line burette).

Intravenous amoxicillin may be given in a range of different intravenous fluids: e Water for injection, e Sodium chloride 0.9%

Ringer NaCl

Ringer Sodium Lactate

Glucose 5%

Intramuscular administration

Vial Diluent

lg 2.5 mL lidocaine hydrochloride solution

The maximum single dose is 1 g.

All solutions should be shaken vigorously before injection and administered immediately after reconstitution. Any residual antibiotic solution should be discarded.

For single use only.

The displacement volumes are presented below:

Vial of Amoxicillin Diluent water for Final volume Displacement injection (mL) after volume (mL) reconstitution (mL) lg 20 20.7 0.7 Vial of Amoxicillin Diluent lidocaine Final volume Displacement hydrochloride (mL) after volume (mL) reconstitution (mL) lg 2.5 3.3 0.8

Frequently asked questions about Amoxicillin 1g, powder for solution for injection/ infusion

How do I take Amoxicillin 1g, powder for solution for injection/ infusion?

Amoxicillin 1g, powder for solution for injection/ infusion comes as powder containing 1g. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.

What is the active substance in Amoxicillin 1g, powder for solution for injection/ infusion?

The active substance in Amoxicillin 1g, powder for solution for injection/ infusion is amoxicillin.

Where does this information come from?

This leaflet reproduces the patient information leaflet approved for Amoxicillin 1g, powder for solution for injection/ infusion, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.

Can I get Amoxicillin 1g, powder for solution for injection/ infusion without a prescription?

Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.

About this leaflet

The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.

Medical disclaimer: This page is for information only and does not replace advice from your doctor or pharmacist. Always read the leaflet supplied with your medicine. If you are unwell, call NHS 111; in an emergency, call 999.

Medicines with the same active substance: Amoxicillin (8 medicines)
See every medicine containing this substance, or browse the full A–Z of active substances.
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
Technical information intended for healthcare professionals (doctors and pharmacists). The Summary of Product Characteristics (SmPC) is the official document approved by the MHRA/EMA. It does not replace the patient leaflet or a doctor’s advice.

4.1. Therapeutic indications

Amoxicillin is indicated for the treatment of the following infections in adults and children (see sections 4.2, 4.4 and 5.1):

• Severe infections of the ear, nose and throat (such as mastoiditis, peritonsillar infections, epiglottitis, and sinusitis when accompanied by severe systemic signs and symptoms)

• Acute exacerbations of chronic bronchitis

• Community acquired pneumonia

• Acute cystitis

• Acute pyelonephritis

• Severe dental abscess with spreading cellulitis

• Prosthetic joint infections

• Lyme disease

• Bacterial meningitis

• Bacteremia that occurs in association with, or is suspected to be associated with, any of the infections listed above

Amoxicillin is also indicated for the treatment and prophylaxis of endocarditis.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

4.2. Posology and method of administration

Posology

The dose of amoxicillin that is selected to treat an individual infection should take into account:

• The expected pathogens and their likely susceptibility to antibacterial agents (see section 4.4)

• The severity and the site of the infection

• The age, weight and renal function of the patient; as shown below

The duration of therapy should be determined by the type of infection and the response of the patient, and should generally be as short as possible. Some infections require longer periods of treatment (see section 4.4 regarding prolonged therapy).

Adults and children ≥ 40 kg

Indication*

Dose*

Severe infections of the ear, nose and throat (such as mastoiditis, peritonsillar infections, epiglottis and sinusitis when accompanied by severe systemic signs and symptoms

750 mg to 2 g every 8 hours, or 2 g every 12 hours, maximum of 12 g/day

Acute exacerbations of chronic bronchitis

Community acquired pneumonia

Acute cystitis

Acute pyelonephritis

Severe dental abscess with spreading cellulitis

Prosthetic joint infections

750 mg to 2 g every 8 hours, or 2 g every 12 hours, maximum of 12 g/day

Prophylaxis of endocarditis

2 g single dose 30 to 60 minutes before procedure.

Treatment of endocarditis

1 g to 2 g every 4 to 6 hours, maximum of 12 g/day

Bacterial meningitis

1 g to 2 g every 4 to 6 hours, maximum of 12 g/day

Lyme disease (see section 4.4)

Late stage (systemic involvement): 2 g every 8 hours

Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed in section 4.1

1 g to 2 g every 4, 6 or 8 hours, maximum of 12 g/day

*Consideration should be given to the official treatment guidelines for each indication

Intramuscular

Maximum daily dosage: 4 g/day.

Maximum single dose: 1 g.

Paediatric population

Infants and toddlers >3 months and children <40 kg Indication*

Dose*

Severe infections of the ear, nose and throat (such as mastoiditis, peritonsillar infections, epiglottis and sinusitis when accompanied by severe systemic signs and symptoms

20 to 200 mg/kg/day given in 2 to 4 equally divided doses of up to 25 mg/kg or infusions of up to 50 mg/kg

Community acquired pneumonia

Acute cystitis

Acute pyelonephritis

Severe dental abscess with spreading cellulitis

Prophylaxis of endocarditis

50 mg/kg single dose 30 to 60 minutes before procedure

Treatment of endocarditis

200 mg/kg/day in 3 to 4 equally divided does of up to 25 mg/kg or infusions of up to 50 mg/kg

Bacterial meningitis

100 to 200 mg/kg/day in 3 to 4 equally divided doses of up to 25 mg/kg or infusions of up to 50 mg/kg

Lyme disease (see section 4.4)

Early stage: 25 to 50 mg/kg/day in three divided doses for 10 days (range 10 to 21 days)

Late stage (systemic involvement): 50 mg/kg/day in three divided doses

Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed in section 4.1

50 to 150 mg/kg/day given in 3 equally divided doses of up to 25 mg/kg or infusions of up to 50 mg/kg

*Consideration should be given to the official treatment guidelines for each indication.

Neonates ≥ 4 kg and infants up to 3 months

Indication*

Dose*

Most infections

Usual daily dose of 20 to 150 mg/kg/day given in 3 equally divided doses of up to 25 mg/kg or infusions of up to 50 mg/kg

Treatment of endocarditis

150 mg/kg/day given in 3 equally divided does of up to 25 mg/kg or infusions of up to 50 mg/kg

Bacterial meningitis

150 mg/kg/day given in three divided doses

Lyme disease (see section 4.4)

Early stage: 25 to 50 mg/kg/day in three divided doses for 10 days (range 10 to 21 days)

Late stage (systemic involvement): 50 mg/kg/day in three divided doses

Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed in section 4.1

Usual daily dose of 50 to 150 mg/kg/day given in 3 equally divided doses of up to 25 mg/kg or infusions of up to 50 mg/kg

*Consideration should be given to the official treatment guidelines for each indication.

Premature Neonates ≤ 4 kg

Indication*

Dose*

Most infections

Usual daily dose of 20 to 100 mg/kg/day given in 2 equally divided doses of up to 25 mg/kg or infusions of up to 50 mg/kg

Treatment of endocarditis

100 mg/kg/day given in two divided does

Bacterial meningitis

100 mg/kg/day given in two divided doses

Lyme disease (see section 4.4)

Early stage: 25 to 50 mg/kg/day in two divided doses for 10 days (range 10 to 21 days)

Late stage (systemic involvement): 50 mg/kg/day in two divided doses

Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed in section 4.1

Usual daily dose of 50 to 100 mg/kg/day given in 2 equally divided doses of up to 25 mg/kg or infusions of up to 50 mg/kg

*Consideration should be given to the official treatment guidelines for each indication.

Intramuscular:

Maximum daily dosage: 120 mg/kg/day as 2 to 6 equally divided doses.

Elderly

No adjustment needed; as for adults.

Renal impairment

Adults and children ≥ 40 kg

Children < 40 kg

GFR

(ml/min)

Intravenous

Intramuscular

Intravenous

Intramuscular

Greater than 30

No adjustment

No adjustment

No adjustment

No adjustment

10 to 30

1 g start, then 500 mg to 1g twice daily

500 mg every 12 hours

25 mg/kg twice daily

15 mg/kg every 12 hours

Less than 10

1 g stat, then 500mg/day

500 mg/day given as a single dose

25 mg/kg/day given as a single dose

15 mg/kg/day given as a single dose

In patients receiving haemodialysis and peritoneal dialysis:

Amoxicillin may be removed from the circulation by haemodialysis.

Haemodialysis

Peritoneal dialysis

Intravenous

Intramuscular

Intravenous

Intramuscular

Adults and children ≥ 40 kg

1 g at the end of dialysis, then 500 mg every 24 hours

500 mg during dialysis, 500 mg at the end, then 500 mg every 24 hours

1 g start, then 500 mg/day

500 mg/day given as a single dose

Children < 40 kg

25 mg/kg stat and 12.5 mg/kg at the end of the dialysis, then 25 mg/kg/day

15 mg/kg during and at the end of dialysis, then 15 mg/kg every 24 hours

25 mg/kg/day given as a single dose

15 mg/kg/day given as a single dose

Method of Administration

The standard recommended route of administration is by intravenous injection or intravenous infusion. Intramuscular administration should only be considered when the intravenous route is not possible or less appropriate for the patient.

Intravenous

Amoxicillin may be administered either by slow intravenous injection over a period of 3 to 4 minutes directly into a vein or via a drip tube or by infusion over 20 to 30 minutes.

Intramuscular

The maximum single dose is 1 g in adults and children > 40 kg.

Do not inject more than 60 mg/kg at one time in children < 40 kg.

4.3. Contraindications

Hypersensitivity to the active substance or to any of the penicillins.

History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam).

4.5. Interaction with other medicinal products and other forms of interaction

Probenecid

Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use of probenecid may result in increased and prolonged blood levels of amoxicillin.

Allopurinol

Concurrent administration of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.

Tetracyclines

Tetracyclines and other bacteriostatic drugs may interfere with the bactericidal effects of amoxicillin.

Oral anticoagulants

Oral anticoagulants and penicillin antibiotics have been widely used in practice without reports of interaction. However, in the literature there are cases of increased international normalised ratio in patients maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin. If coadministration is necessary, the prothrombin time or international normalised ratio should be carefully monitored with the addition or withdrawal of amoxicillin. Moreover, adjustments in the dose of oral anticoagulants may be necessary (see sections 4.4 and 4.8).

Methotrexate

Penicillins may reduce the excretion of methotrexate causing a potential increase in toxicity.

4.6. Fertility, pregnancy and lactation

Pregnancy

Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. Limited data on the use of amoxicillin during pregnancy in humans do not indicate an increased risk of congenital malformations. Amoxicillin may be used in pregnancy when the potential benefits outweigh the potential risks associated with treatment.

Breast-feeding

Amoxicillin is excreted into breast milk in small quantities with the possible risk of sensitisation. Consequently, diarrhoea and fungus infection of the mucous membranes are possible in the breast-fed infant, so that breast-feeding might have to be discontinued. Amoxicillin should only be used during breastfeeding after benefit/risk assessment by the physician in charge.

Fertility

There are no data on the effects of amoxicillin on fertility in humans. Reproductive studies in animals have shown no effects on fertility.

4.7. Effects on ability to drive and use machines

No studies on the effects on the ability to drive and use machines have been performed. However, undesirable effects may occur (e.g. allergic reactions, dizziness, convulsions), which may influence the ability to drive and use machines (see section 4.8).

4.9. Overdose

Symptoms and signs of overdose

Gastrointestinal symptoms (such as nausea, vomiting and diarrhoea) and disturbance of the fluid and electrolyte balances may be evident. Amoxicillin crystalluria, in some cases leading to renal failure, has been observed. Convulsions may occur in patients with impaired renal function or in those receiving high doses (see sections 4.4 and 4.8).

Amoxicillin has been reported to precipitate in bladder catheters, predominantly after intravenous administration of large doses. A regular check of patency should be maintained (see section 4.4)

Treatment of intoxication

Gastrointestinal symptoms may be treated symptomatically, with attention to the water/electrolyte balance.

Amoxicillin can be removed from the circulation by haemodialysis.

💬 Ask about this leaflet

Ask anything about Amoxicillin 1g, powder for solution for injection/ infusion. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.

Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.

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