Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Sodium chloride, Glucose monohydrate may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
What it is and what it is used for
for 2. Before you are given this medicine 3. How to use this medicine 4. Possible side effects 5. How to store this medicine 6. Further information 1. WHAT SODIUM CHLORIDE 0.9% W/V AND GLUCOSE 5% W/V IV INFUSION BP IS AND WHAT IT IS USED FOR This medicine contains normal salt and glucose (also called grape sugar or dextrose). It is given to you as a venous drip (infusion). It will be given to you
- to maintain your fluid and salt levels especially if your blood has become too alkaline in combination with low chloride blood levels (hypochloraemic alkalosis)
- if you are lacking water and salt
- if you have lost chloride
- as a partial calorie source to meet your energy requirements. It may also be used to dilute or dissolve medicines that are to be given to you by a venous drip. 2. BEFORE YOU ARE GIVEN THIS MEDICINE. You should not receive this medicine if you suffer from any of the following:
- excess water in your body tissues (hyperhydration), associated with swelling of the limbs
- abnormally high levels of electrolytes in your body fluids and tissues due to loss of water (hypertonic dehydration)
- uncorrected low blood potassium levels
- your blood has become too acidic (metabolic acidosis)
- abnormally high blood sugar level that only responds to high insulin doses or intolerance to glucose
- water on the lungs or in your brain
- heart failure (decompensated cardiac insufficiency) Special care will be taken with this medicine if you suffer from any of the following:
- abnormally high levels of sodium or chloride in your blood
- disorders where restriction of sodium intake is indicated, such as
- heart failure
- severe kidney problems
- swelling of the limbs, too much water in your body tissues (generalized oedema)
- lung disease or congestion of, or water on the lungs (pulmonary oedema)
- high blood pressure (hypertension)
- eclampsia (see section 'pregnancy and breast-feeding') If you suffer from acute stroke or if your blood sugar levels are too high, your doctor will take special care with you: He/she will correct your blood sugar level before you receive this solution. While you are given this medicine your water balance, salt levels (especially potassium) and blood sugar levels will be monitored by your doctor. After major operations or severe injuries (post-traumatic and postoperative conditions) you may not be able to metabolise glucose properly (impaired glucose tolerance). Then your blood sugar level will be regularly monitored. If you suffer from diabetes mellitus, your doctor will carefully monitor your blood sugar level and modify your insulin requirements. If your blood sodium levels are chronically low, your doctor will take into account that your blood sodium levels must not increase too fast. Please note: If this solution is used to dilute or dissolve medicines that are to be given to you by a venous drip your doctor will take into account the safety information of the additive. Taking or using other medicines Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Your doctor will adjust a your dosage if you receive cortisone. Cortisone may cause an accumulation of sodium and fluid in your body. Pregnancy and breast-feeding Pregnancy If you think you are likely to be pregnant, tell your doctor immediately. Your doctor will give you this medicine only with caution. Special care will be taken if you have a specific disorder that may occur during pregnancy, called eclampsia, with the following symptoms: high blood pressure, cramps, swelling. If you receive this medicine during labour, the blood glucose level of your child may be altered.
Blood glucose levels will be carefully monitored. Breast-feeding If you are breast-feeding, tell your doctor immediately. This medicine can be given while you are breast feeding. Fertility Not relevant Driving and using machines This medicine has no influence on the ability to drive or use machines.
How to take it
THIS MEDICINE The medicine will be administered to you by infusion (a drip) through a vein. Dosage Adults The amount of the medicine that you will be given will be determined by your doctor and will depend on your age, weight, clinical condition and other therapies needed. Thus your individual requirements of fluid, electrolytes and energy will be taken into account. The normal maximum dosage for an adult is 40 ml/kg body weight/day. The maximum infusion rate is 5 ml per kg body weight per hour. Children Children will receive a reduced dosage dependent upon their age, weight and clinical condition. Thus the individual daily requirements of fluid, electrolytes and energy of your child will be taken into account. Elderly patients Basically the same dosage as for adults applies. But your doctor will take caution if you are suffering from other diseases often seen with advanced age. For example heart failure or kidney failure Other special patient groups Special care will be taken if you have an impaired glucose tolerance (e.g. after surgery, severe injury, diabetes, organ failure etc.). In those cases your blood glucose level will be monitored while you receive this solution.
If you received more Sodium Chloride 0.9% w/v and Glucose 5% w/v IV Infusion BP than you should It is unlikely that this happens as your infusion will be controlled by a doctor or nurse. Symptoms An overdose may lead to hyperhydration (excess fluid in the body), which will be followed by
- increased skin tension
- congestion of your blood
- swelling
- water on the lungs and in your brain
- disorders of your salt and acid-base balance. It may also lead to
- high blood sugar values. Treatment The therapy to normalise your condition will be determined by your doctor. It may include stopping of the infusion, supervision of blood salt level and administration of suitable medicines to treat the symptoms observed (e.g. diuretics, insulin). In extreme situations you may also need dialysis. If you have any further questions on the use of this product, ask your doctor or pharmacist. 4. POSSIBLE SIDE EFFECTS Like all medicines, Sodium Chloride 0.9% w/v and Glucose 5% w/v IV Infusion BP can cause side effects although not everybody gets them.
Possible side effects
may be associated to the technique of administration including febrile response, infection at the site of injection, local pain or reaction, vein irritation, venous thrombosis or phlebitis. If you notice any side effects, please tell your doctor or pharmacist. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
How to store it
THIS MEDICINE Keep this medicine out of the reach and sight of children. Do not use this medicine after the expiry date which is stated on the label and the outer carton. The expiry date refers to the last day of that month. This medicine is for single use only. After use discard container and any unused medicine. Do not reconnect partially used containers. This medicine does not require any special storage conditions. Only to be used if solution is clear and colourless and the container and its closure are undamaged. Any unused product or waste material should be disposed of in accordance with local requirements. 6. FURTHER INFORMATION What Sodium Chloride 0.9% w/v and Glucose 5% w/v IV Infusion BP contains
- The active substances are sodium chloride and glucose. 1000 ml of the solution contain Sodium chloride Glucose
9.0 g 50.0 g (as glucose monohydrate)
- The other ingredient is water for Injections Energy: Theoretical osmolarity: Acidity (titration to pH 7.4): pH:
835 mOsm/l kJ/l ≙ 200 kcal/l 586 < 0.5 mmol/l 3.5 – 5.5
What Sodium Chloride 0.9% w/v and Glucose 5% w/v IV Infusion BP looks like and contents of the pack It is a clear colourless sterile solution of sodium chloride and glucose in water. It is supplied in
- polyethylene plastic bottles; contents 500 ml or 1000 ml available in packs of 1 x 500 ml, 10 × 500 ml 1 x 1000 ml, 10 × 1000 ml Marketing authorisation holder B. Braun Melsungen AG Carl-Braun-Straße 1 34212 Melsungen, Germany Postal address: B. Braun Melsungen AG 34209 Melsungen, Germany Tel: +49-(0)-5661-71-0 Fax: +49-(0)-5661-4567 Manufacturer B. Braun Melsungen AG Carl-Braun-Straße 1 34212 Melsungen, Germany or B. Braun Medical S.A. Carretera de Terrassa 121 08191 Rubí, Barcelona, Spain This leaflet was last revised in May 2014 The following information is only intended for health-care professionals: Method of administration: The solution should not be administered through the same infusion equipment simultaneously, before or after an administration of blood because of the possibility of pseudo-agglutination. Hypertonic solutions should be administered in a large peripheral or central vein to diminish the risk of causing irritation. Important information about the container: The plastic container contains a significant volume of air. To avoid risk of air embolism, all air must be expelled before starting a pressure infusion. Dosage:
Partial coverage of energy requirements, i. e. substitution of the obligatory daily glucose requirements, is only possible with the maximum dose stated above
Frequently asked questions about Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP
How do I take Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP?
Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP comes as infusion. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP?
The active substance in Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP is sodium chloride, glucose monohydrate.
Are there equivalent medicines to Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP?
Medicines with the same active substance, strength and form include: 5% GLUCOSE INTRAVENOUS INFUSION SOLUTION, Potassium Chloride 0.15 % w/v and Glucose 10 % w/v Solution for Infusion BP, Potassium Chloride 0.15 % w/v and Glucose 5% w/v Solution for Infusion -BP. In total there are 26 equivalent products. They are interchangeable only if your prescriber or pharmacist says so.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: sodium chloride, glucose monohydrate
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
• Fluid and electrolyte substitution in hypochloraemic alkalosis
• Chloride losses
• Hypotonic dehydration
• Isotonic dehydration
• Partial coverage of energy requirements
• Vehicle solution for compatible electrolyte concentrates and medicaments
4.2. Posology and method of administration
Posology
Adults
The dose is adjusted according to the individual requirements of fluid, electrolyte and energy. thus the patient`s age, weight, clinical and biological (acid-base balance) conditions and concomitant therapy should be taken into account.
Maximum daily dose:
40 ml/kg body weight (BW) per day, corresponding to 2 g glucose/kg BW per day and 6 mmol of sodium /kg BW per day
Maximum infusion rate:
5 ml/kg BW per hour, corresponding to 0.25 g glucose/kg BW per hour.
Partial coverage of energy requirements, i. e. substitution of the obligatory daily glucose requirements, is only possible with the maximum dose stated above.
Padiatric patients
The dose is adjusted according to the individual requirements of fluid, electrolytes and energy. Thus the patients age, weight, clinical and biological (acid-base balance) conditions and concomitant therapy should be taken into account.
When administering this solution the total daily fluid and glucose requirements should be taken into account.
Elderly patients
Basically the same dosage as for adults applies, but caution should be exercised in patients suffering from further diseases like cardiac insufficiency or renal insufficiency that may frequently be associated with advanced age.
Other special patient groups
If the oxidative metabolism of glucose is impaired (e.g. in the early post-operative or post-traumatic period or in the presence of hypoxia or organ failure), the dosage should be adjusted to keep the blood glucose level close to normal values. Close monitoring of blood glucose levels is recommended in order to prevent hyperglycaemia. See also section 4.4.
Method of administration
Intravenous use
Hypertonic solutions should be administered in a large peripheral or central vein to diminish the risk of causing irritaion.
This container contains a significant volume of air. To avoid risk of air embolism, this product must not be administered by pressure infusion.
4.3. Contraindications
Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP must not be used in cases of
• hyperhydration
• hypertonic dehydration
• untreated hypokalaemia
• metabolic acidosis
• persistent hyperglycaemia not responding to insulin doses of up to 6 units/hour
• pulmonary or brain oedema
• decompensated cardiac insufficiency
4.4. Special warnings and precautions for use
Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP should only be administered with caution in cases of
• hypernatraemia
• hyperchloraemia
• disorders where restriction of sodium intake is indicated, such as cardiac insufficiency, generalized oedema, pulmonary oedema, hypertension, eclampsia, severe renal insufficiency
In patients with acute ischaemic stroke and hyperglycaemia the glucose level should be corrected before application of this solution.
In diabetic patients, the amount of infused glucose has to be taken into account and insulin requirements may be modified.
To prevent development of the osmotic demyelination syndrome in patients with chronic hyponatraemia the rate of administration should be sufficiently low, so that the serum sodium will not increase faster than by 0.35 - 0.5 mmol/h corresponding to 8 - 12 mmol/l/d.
Please note: If this solution is used as vehicle solution the safety information of the additive provided by the respective manufacturer have to be taken into account.
Clinical monitoring should include checks of the serum electrolytes (especially potassium), glucose level, the acid-base and water balance.
In post-operative and post-traumatic conditions, and in conditions of impaired glucose tolerance: only administer with monitoring of blood glucose level.
The solution should not be administered through the same infusion equipment simultaneously, before or after an administration of blood because of the possibility of pseudo-agglutination.
In case of an adverse reaction, infusion must be stopped immediately.
4.5. Interaction with other medicinal products and other forms of interaction
Corticosteroids
Corticosteroids are associated with the retention of sodium and fluid
4.6. Pregnancy and lactation
Pregnancy
There is a limited amount of data from the use of this Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP in pregnant women. Animal studies relating to glucose and sodium chloride do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3).
Therefore caution should be exercised when prescribing to pregnant women, especially in the presence of eclampsia (see section 4.4).
Careful monitoring of blood glucose is necessary.
Lactation
It is unknown wether Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP or metabolites are excreted into breast-milk. As all active ingredients are present in human body, no negative effects are anticipated if used during lactation. Therefore, the solution can be used as indicated.
Fertility
Not relevant
4.7. Effects on ability to drive and use machines
Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP has no influence on the ability to drive and use machines.
4.8. Undesirable effects
Adverse reactions may be associated to the technique of administration including febrile response, infection at the site of injection, local pain or reaction, vein irritation, venous thrombosis or phlebitis.
Adverse reactions may be associated with the medications added to the solution; the nature of the additive will determine the likelihood of any other undesirable effects.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
4.9. Overdose
Symptoms
Overdose may result in hyperhydration, with increased skin tension, venous congestion, oedema - possibly also lung or brain oedema -, dilution of serum electrolytes,electrolyte imbalances, notably hypernatraemia, hyperchloraemia (see section 4.8) and hypokalaemia, acid-base imbalances, hyperglycaemia, and hyperosmolarity of the serum (up to hyperglycaemic-hyperosmolar coma).
Treatment
Dependent on the severity of the disorders immediate stop of infusion, administration of diuretics with continuous monitoring of serum electrolytes, correction of electrolyte and acid-base imbalances, administration of insulin if necessary.
In severe cases of overdose dialysis may be necessary.
💬 Ask about this leaflet
Ask anything about Sodium Chloride 0.9 % w/v and Glucose 5 % w/v Intravenous Infusion BP. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.