Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.

Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.

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Seebri Breezhaler 44 micrograms inhalation powder (hard capsules)

⚠ This medicine appears to have been discontinued

The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.

If you were prescribed this medicine, other products containing Glycopyrronium bromide may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.

Active substance: Glycopyrronium bromide
Source: electronic medicines compendium (emc)
Official leaflet: Read the PIL on emc

What it is and what it is used for

for

What Seebri Breezhaler is This medicine contains an active substance called glycopyrronium bromide. This belongs to a group of medicines called bronchodilators. What Seebri Breezhaler is used for This medicine is used to make breathing easier for adult patients who have breathing difficulties due to a lung disease called chronic obstructive pulmonary disease (COPD). In COPD the muscles around the airways tighten. This makes breathing difficult. This medicine blocks the tightening of these muscles in the lungs, making it easier for air to get in and out of the lungs. If you use this medicine once a day, it will help to reduce the effects of COPD on your everyday life. 2.

What you need to know before you take it

e Seebri Breezhaler

Do not use Seebri Breezhaler

  • if you are allergic to glycopyrronium bromide or any of the other ingredients of this medicine (listed in section 6). Warnings and precautions Talk to your doctor before using Seebri Breezhaler, if any of the following applies to you: you have kidney problems. you have an eye problem called narrow-angle glaucoma. you have difficulty passing urine.

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During treatment with Seebri Breezhaler, stop taking this medicine and tell your doctor immediately: if you experience tightness of the chest, coughing, wheezing or breathlessness immediately after using Seebri Breezhaler (signs of bronchospasm). if you experience difficulties in breathing or swallowing, swelling of the tongue, lips or face, skin rash, itching and hives (signs of allergic reaction). if you experience eye pain or discomfort, temporary blurring of vision, visual halos or coloured images in association with red eyes. These may be signs of an acute attack of narrow-angle glaucoma. Seebri Breezhaler is used as a maintenance treatment for your COPD. Do not use this medicine to treat a sudden attack of breathlessness or wheezing. Children and adolescents Do not give this medicine to children or adolescents below the age of 18 years. Other medicines and Seebri Breezhaler Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines similar to Seebri Breezhaler used for your lung disease, such as ipratropium, oxitropium or tiotropium (so called anticholinergics). No specific side effects have been reported when Seebri Breezhaler has been used together with other medicines used to treat COPD such as reliever inhalers (e.g. salbutamol), methylxanthines (e.g. theophylline) and/or oral and inhaled steroids (e.g. prednisolone). Pregnancy, breast-feeding and fertility If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. There are no data from the use of this medicine in pregnant women and it is not known whether the active substance of this medicine passes into human milk. Driving and using machines It is unlikely that this medicine will affect your ability to drive and use machines. Seebri Breezhaler contains lactose This medicine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. 3.

How to take it

Seebri Breezhaler

Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. How much Seebri Breezhaler to use The usual dose is to inhale the content of one capsule each day. You only need to inhale once a day because the effect of this medicine lasts for 24 hours. Do not use more than your doctor tells you to use. Elderly people You can use this medicine if you are aged 75 years and over at the same dose as for other adults. When to inhale Seebri Breezhaler Use this medicine at the same time each day. This will also help you to remember to use it.

2

You can inhale this medicine any time before or after food or drink. How to inhale Seebri Breezhaler In this pack, you will find an inhaler and capsules (in blisters) that contain the medicine as inhalation powder. Only use the capsules with the inhaler provided in this pack (Seebri Breezhaler inhaler). The capsules should remain in the blister until you need to use them. Do not push the capsule through the foil. When you start a new pack, use the new Seebri Breezhaler inhaler that is supplied in the pack. Dispose of each inhaler after all capsules in that pack have been used. Do not swallow the capsules. Please read the instructions at the end of this leaflet for more information on how to use the inhaler. If you use more Seebri Breezhaler than you should If you have inhaled too much of this medicine or if someone else accidentally uses your capsules, you must immediately either tell your doctor or go to the nearest emergency unit. Show the pack of Seebri Breezhaler. Medical attention may be needed. If you forget to use Seebri Breezhaler If you forget to inhale a dose, take one as soon as possible. However, do not take two doses on the same day. Then take the next dose as usual. How long to continue your treatment with Seebri Breezhaler Keep using this medicine for as long as your doctor tells you. COPD is a long-term disease and you should use this medicine every day and not only when you have breathing problems or other symptoms of COPD. If you have questions about how long to continue your treatment with this medicine, talk to your doctor or pharmacist. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse. 4.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Some side effects may be serious but are uncommon (may affect up to 1 in 100 people) • Irregular heart beat • High level of blood sugar (hyperglycaemia: typical symptoms include excessive thirst or hunger and frequent urination) • Rash, itching, hives, difficulty breathing or swallowing, dizziness (possible signs of allergic reaction) • Swelling mainly of the tongue, lips, face or throat (possible signs of angioedema) If you get any of these side effects, tell your doctor immediately. Some side effects may be serious, but the frequency of these side effects is not known (frequency cannot be estimated from the available data) • Difficulty breathing with wheezing or coughing (signs of paradoxical bronchospasm) Some side effects are common (may affect up to 1 in 10 people) • Dry mouth • Difficulty sleeping 3

• • •

Runny or stuffy nose, sneezing, sore throat Diarrhoea or stomach ache Musculoskeletal pain

Some side effects are uncommon (may affect up to 1 in 100 people) • Difficulty and pain when passing urine • Painful and frequent urination • Palpitations • Rash • Numbness • Cough with sputum • Dental caries • Feeling of pressure or pain in the cheeks and forehead • Nose bleeds • Pain in arms or legs • Pain in muscles, bones or joints of the chest • Stomach discomfort after meals • Throat irritation • Tiredness • Weakness • Itching • Voice alteration (hoarseness) • Nausea • Vomiting Some elderly patients above 75 years of age experienced headache (frequency common) and urinary tract infection (frequency common). Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine. 5.

How to store it

Seebri Breezhaler

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister after "EXP". The expiry date refers to the last day of that month. Do not store above 25°C. Store the capsules in the original blister in order to protect from moisture. Do not remove from the blister until immediately before use. The inhaler in each pack should be disposed of after all capsules in that pack have been used. Do not use this medicine if you notice that the pack is damaged or shows signs of tampering. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to

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throw away medicines you no longer use. These measures will help protect the environment. 6.

Contents of the pack and other information

What Seebri Breezhaler contains The active substance is glycopyrronium bromide. Each capsule contains 63 micrograms of glycopyrronium bromide (equivalent to 50 micrograms glycopyrronium). The delivered dose (the dose that leaves the mouthpiece of the inhaler) is equivalent to 44 micrograms of glycopyrronium. The other ingredients of the inhalation powder are lactose monohydrate and magnesium stearate.

  • The ingredients of the capsule shell are hypromellose, carrageenan, potassium chloride, sunset yellow FCF (E110) and printing ink.
  • The ingredients of the printing ink are shellac (E904), propylene glycol, ammonium hydroxide, potassium hydroxide and iron oxide, black (E172). What Seebri Breezhaler looks like and contents of the pack Seebri Breezhaler 44 micrograms inhalation powder, hard capsules are transparent and orange and contain a white powder. They have the product code "GPL50" printed in black above and a company logo ( ) printed in black below a black bar. Each pack contains a device called an inhaler, together with capsules in blisters. Each blister strip contains either 6 or 10 hard capsules. The following pack sizes are available: Packs containing 6×1, 10×1, 12×1 or 30×1 hard capsules, together with one inhaler. Multipacks containing 90 (3 packs of 30×1) hard capsules and 3 inhalers. Multipacks containing 96 (4 packs of 24×1) hard capsules and 4 inhalers. Multipacks containing 150 (15 packs of 10×1) hard capsules and 15 inhalers. Multipacks containing 150 (25 packs of 6×1) hard capsules and 25 inhalers. Not all pack sizes may be available in your country. Marketing Authorisation Holder Novartis Pharmaceuticals UK Limited 2nd Floor, The WestWorks Building, White City Place 195 Wood Lane London W12 7FQ United Kingdom Manufacturer Novartis Pharmaceuticals UK Limited 2nd Floor, The WestWorks Building, White City Place 195 Wood Lane London W12 7FQ United Kingdom For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder: 5

United Kingdom Novartis Pharmaceuticals UK Ltd. Tel: +44 1276 698370 This leaflet was last revised in 06/2026

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Instructions for use of Seebri Breezhaler inhaler Please read the full Instructions for Use before using the Seebri Breezhaler.

Insert

Pierce and release

Inhale deeply

Check capsule is empty

1

2

3

Check

Step 1a: Pull off cap

Step 2a: Pierce capsule once Hold the inhaler upright. Pierce capsule by firmly pressing both side buttons at the same time. You should hear a noise as the capsule is pierced. Only pierce the capsule once.

Step 1b: Open inhaler

Step 3a: Breathe out fully Do not blow into the inhaler.

If there is powder left in the capsule:

  • Close the inhaler.
  • Repeat steps 3a to 3c.

Step 3b: Inhale medicine deeply Hold the inhaler as shown in the picture. Place the mouthpiece in your mouth and close your lips firmly around it. Do not press the side buttons.

Step 2b: Release side buttons

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Check capsule is empty Open the inhaler to see if any powder is left in the capsule.

Powder remaining

Empty

Breathe in quickly and as deeply as you can. During inhalation you will hear a whirring noise. You may taste the medicine as you inhale.

Remove empty capsule Put the empty capsule in your household waste. Close the inhaler and replace the cap.

Step 1c: Remove capsule Separate one of the blisters from the blister card. Peel open the blister and remove the capsule. Do not push the capsule through the foil. Do not swallow the capsule.

Step 3c: Hold breath Hold your breath for up to 5 seconds. Important Information

  • Seebri Breezhaler capsules must always be stored in the blister card and only removed immediately before use.
  • Do not push the capsule through the foil to remove it from the blister.
  • Do not swallow the capsule.
  • Do not use the Seebri Breezhaler capsules with any other inhaler.
  • Do not use the Seebri Breezhaler inhaler to take any other capsule medicine.
  • Never place the capsule into your mouth or the mouthpiece of the inhaler.
  • Do not press the side buttons more than once.
  • Do not blow into the mouthpiece.
  • Do not press the side buttons while inhaling through the mouthpiece.
  • Do not handle capsules with wet hands.
  • Never wash your inhaler with water.

Step 1d: Insert capsule Never place a capsule directly into the mouthpiece.

Step 1e: Close inhaler

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Frequently Asked Questions

Your Seebri Breezhaler Inhaler pack contains:

  • One Seebri Breezhaler inhaler
  • One or more blister cards, each containing either 6 or 10 Seebri Breezhaler capsules to be used in the inhaler Cap

Capsule chamber

Why didn't the inhaler make a noise when I inhaled? The capsule may be stuck in the capsule chamber. If this happens, carefully loosen the capsule by tapping the base of the inhaler. Inhale the medicine again by repeating steps 3a to 3c.

Mouthpiece

Screen

Base Inhaler

Side buttons

Blister Inhaler base

Blister Card

What should I do if there is powder left inside the capsule? You have not received enough of your medicine. Close the inhaler and repeat steps 3a to 3c. I coughed after inhaling

  • does this matter? This may happen. As long as the capsule is empty you have received enough of your medicine. I felt small pieces of the capsule on my tongue – does this matter? This can happen. It is not harmful. The chances of the capsule breaking into small pieces will be increased if the capsule is pierced more than once.

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Cleaning the inhaler Wipe the mouthpiece inside and outside with a clean, dry, lint-free cloth to remove any powder residue. Keep the inhaler dry. Never wash your inhaler with water.

Disposing of the inhaler after use Each inhaler should be disposed of after all capsules have been used. Ask your pharmacist how to dispose of medicines and inhalers that are no longer required.

Frequently asked questions about Seebri Breezhaler 44 micrograms inhalation powder (hard capsules)

How do I take Seebri Breezhaler 44 micrograms inhalation powder (hard capsules)?

Seebri Breezhaler 44 micrograms inhalation powder (hard capsules) comes as capsule containing 44mcg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.

What is the active substance in Seebri Breezhaler 44 micrograms inhalation powder (hard capsules)?

The active substance in Seebri Breezhaler 44 micrograms inhalation powder (hard capsules) is glycopyrronium bromide.

Where does this information come from?

This leaflet reproduces the patient information leaflet approved for Seebri Breezhaler 44 micrograms inhalation powder (hard capsules), as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.

Can I get Seebri Breezhaler 44 micrograms inhalation powder (hard capsules) without a prescription?

Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.

About this leaflet

The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.

Medical disclaimer: This page is for information only and does not replace advice from your doctor or pharmacist. Always read the leaflet supplied with your medicine. If you are unwell, call NHS 111; in an emergency, call 999.

Medicines with the same active substance: Glycopyrronium bromide (30 medicines)
See every medicine containing this substance, or browse the full A–Z of active substances.
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
Technical information intended for healthcare professionals (doctors and pharmacists). The Summary of Product Characteristics (SmPC) is the official document approved by the MHRA/EMA. It does not replace the patient leaflet or a doctor’s advice.

4.1. Therapeutic indications

Seebri Breezhaler is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).

4.2. Posology and method of administration

Posology

The recommended dose is the inhalation of the content of one capsule once daily using the Seebri Breezhaler inhaler.

Seebri Breezhaler is recommended to be administered, at the same time of the day each day. If a dose is missed, the next dose should be taken as soon as possible. Patients should be instructed not to take more than one dose in a day.

Special populations

Elderly population

Seebri Breezhaler can be used at the recommended dose in elderly patients (75 years of age and older) (see section 4.8).

Renal impairment

Seebri Breezhaler can be used at the recommended dose in patients with mild to moderate renal impairment. In patients with severe renal impairment or end-stage renal disease requiring dialysis Seebri Breezhaler should be used only if the expected benefit outweighs the potential risk since the systemic exposure to glycopyrronium may be increased in this population (see sections 4.4 and 5.2).

Hepatic impairment

No studies have been conducted in patients with hepatic impairment. Glycopyrronium is predominantly cleared by renal excretion and therefore no major increase in exposure is expected in patients with hepatic impairment. No dose adjustment is required in patients with hepatic impairment.

Paediatric population

There is no relevant use of Seebri Breezhaler in the paediatric population (under 18 years) in the indication COPD.

Method of administration

For inhalation use only.

The capsules must be administered only using the Seebri Breezhaler inhaler (see section 6.6).

The capsules must only be removed from the blister immediately before use.

The capsules must not be swallowed.

Patients should be instructed on how to administer the medicinal product correctly. Patients who do not experience improvement in breathing should be asked if they are swallowing the medicinal product rather than inhaling it.

For instructions on use of the medicinal product before administration, see section 6.6.

4.3. Contraindications

Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.

4.4. Special warnings and precautions for use

Not for acute use

Seebri Breezhaler is a once-daily, long-term maintenance treatment and is not indicated for the initial treatment of acute episodes of bronchospasm, i.e. as a rescue therapy.

Hypersensitivity

Immediate hypersensitivity reactions have been reported after administration of Seebri Breezhaler. If signs suggesting allergic reactions occur, in particular, angioedema (including difficulties in breathing or swallowing, swelling of the tongue, lips, and face), urticaria or skin rash, treatment should be discontinued immediately and alternative therapy instituted.

Paradoxical bronchospasm

In clinical studies with Seebri Breezhaler, paradoxical bronchospasm was not observed. However, paradoxical bronchospasm has been observed with other inhalation therapy and can be life-threatening. If this occurs, treatment should be discontinued immediately and alternative therapy instituted.

Anticholinergic effect

Seebri Breezhaler should be used with caution in patients with narrow-angle glaucoma or urinary retention.

Patients should be informed about the signs and symptoms of acute narrow-angle glaucoma and should be informed to stop using Seebri Breezhaler and to contact their doctor immediately should any of these signs or symptoms develop.

Patients with severe renal impairment

A moderate mean increase in total systemic exposure (AUClast) of up to 1.4-fold was seen in subjects with mild and moderate renal impairment and up to 2.2-fold in subjects with severe renal impairment and end-stage renal disease. In patients with severe renal impairment (estimated glomerular filtration rate below 30 ml/min/1.73 m2), including those with end-stage renal disease requiring dialysis, Seebri Breezhaler should be used only if the expected benefit outweighs the potential risk (see section 5.2). These patients should be monitored closely for potential adverse reactions.

Patients with a history of cardiovascular disease

Patients with unstable ischaemic heart disease, left ventricular failure, history of myocardial infarction, arrhythmia (excluding chronic stable atrial fibrillation), a history of long QT syndrome or whose QTc (Fridericia method) was prolonged (>450 ms for males or >470 ms for females) were excluded from the clinical trials, and therefore the experience in these patient groups is limited. Seebri Breezhaler should be used with caution in these patient groups.

Excipients

Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.

4.5. Interaction with other medicinal products and other forms of interaction

The co-administration of Seebri Breezhaler with other anticholinergic-containing medicinal products has not been studied and is therefore not recommended.

Although no formal drug interaction studies have been performed, Seebri Breezhaler has been used concomitantly with other medicinal products commonly used in the treatment of COPD without clinical evidence of drug interactions. These include sympathomimetic bronchodilators, methylxanthines, and oral and inhaled steroids.

In a clinical study in healthy volunteers, cimetidine, an inhibitor of organic cation transport which is thought to contribute to the renal excretion of glycopyrronium, increased total exposure (AUC) to glycopyrronium by 22% and decreased renal clearance by 23%. Based on the magnitude of these changes, no clinically relevant drug interaction is expected when glycopyrronium is co-administered with cimetidine or other inhibitors of organic cation transport.

Concomitant administration of glycopyrronium and orally inhaled indacaterol, a beta2-adrenergic agonist, under steady-state conditions of both active substances did not affect the pharmacokinetics of either medicinal product.

4.6. Fertility, pregnancy and lactation

Pregnancy

There are no data from the use of Seebri Breezhaler in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). Glycopyrronium should only be used during pregnancy if the expected benefit to the patient justifies the potential risk to the foetus.

Breast-feeding

It is unknown whether glycopyrronium bromide is excreted in human milk. However, glycopyrronium bromide (including its metabolites) was excreted in the milk of lactating rats (see section 5.3). The use of glycopyrronium by breast-feeding women should only be considered if the expected benefit to the woman is greater than any possible risk to the infant (see section 5.3).

Fertility

Reproduction studies and other data in animals do not indicate a concern regarding fertility in either males or females (see section 5.3).

4.7. Effects on ability to drive and use machines

Glycopyrronium has no or negligible influence on the ability to drive and use machines.

4.8. Undesirable effects

Summary of the safety profile

The most common anticholinergic adverse reaction was dry mouth (2.4%). The majority of the reports of dry mouth were suspected to be related to the medicinal product and were mild, with none being severe.

The safety profile is further characterised by other symptoms related to the anticholinergic effects, including signs of urinary retention, which were uncommon. Gastrointestinal effects including gastroenteritis and dyspepsia were also observed. Adverse reactions related to local tolerability included throat irritation, nasopharyngitis, rhinitis and sinusitis.

Tabulated summary of adverse reactions

Adverse reactions reported during the first six months of two pooled pivotal Phase III trials of 6 and 12 months duration are listed by MedDRA system organ class (Table 1). Within each system organ class, the adverse reactions are ranked by frequency, with the most frequent reactions first. Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness. In addition, the corresponding frequency category for each adverse reaction is based on the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data).

Table 1 Adverse reactions

Adverse reactions

Frequency category

Infections and infestations

Nasopharyngitis1)

Common

Rhinitis

Uncommon

Cystitis

Uncommon

Immune system disorders

Hypersensitivity

Uncommon

Angioedema2)

Uncommon

Metabolism and nutrition disorders

Hyperglycaemia

Uncommon

Psychiatric disorders

Insomnia

Common

Nervous system disorders

Headache3)

Common

Hypoaesthesia

Uncommon

Cardiac disorders

Atrial fibrillation

Uncommon

Palpitations

Uncommon

Respiratory, thoracic and mediastinal disorders

Sinus congestion

Uncommon

Productive cough

Uncommon

Throat irritation

Uncommon

Epistaxis

Uncommon

Dysphonia2)

Uncommon

Paradoxical bronchospasm2)

Not known

Gastrointestinal disorders

Dry mouth

Common

Gastroenteritis

Common

Nausea2)

Uncommon

Vomiting1) 2)

Uncommon

Dyspepsia

Uncommon

Dental caries

Uncommon

Skin and subcutaneous tissue disorders

Rash

Uncommon

Pruritus2)

Uncommon

Musculoskeletal and connective tissue disorders

Musculoskeletal pain1) 2)

Common

Pain in extremity

Uncommon

Musculoskeletal chest pain

Uncommon

Renal and urinary disorders

Urinary tract infection3)

Common

Dysuria

Uncommon

Urinary retention

Uncommon

General disorders and administration site conditions

Fatigue

Uncommon

Asthenia

Uncommon

1) More frequent for glycopyrronium than placebo in the 12 months database only.

2) Reports have been received from post-approval marketing experience in association with the use of Seebri Breezhaler. These were reported voluntarily from a population of uncertain size, and it is therefore not always possible to reliably estimate the frequency or establish a causal relationship to drug exposure. Therefore the frequency was calculated from clinical trial experience.

3) Seen more frequently for glycopyrronium than placebo in elderly >75 years only.

Description of selected adverse reactions

In the pooled 6-month database the frequency of dry mouth was 2.2% versus 1.1%, of insomnia 1.0% versus 0.8%, and of gastroenteritis 1.4% versus 0.9%, for Seebri Breezhaler and placebo respectively.

Dry mouth was reported mainly during the first 4 weeks of treatment with a median duration of four weeks in the majority of patients. However in 40% of cases symptoms continued for the entire 6-month period. No new cases of dry mouth were reported in months 7-12.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

4.9. Overdose

High doses of glycopyrronium may lead to anticholinergic signs and symptoms for which symptomatic treatment may be indicated.

Acute intoxication by inadvertent oral ingestion of Seebri Breezhaler capsules is unlikely due to the low oral bioavailability (about 5%).

Peak plasma levels and total systemic exposure following intravenous administration of 150 micrograms glycopyrronium bromide (equivalent to 120 micrograms glycopyrronium) in healthy volunteers were respectively about 50-fold and 6-fold higher than the peak and total exposure at steady-state achieved with the recommended dose (44 micrograms once daily) of Seebri Breezhaler and were well tolerated.

🇵🇱 Known in Poland as

Medicines sold in Poland with the same active substance: W Polsce znany jako

  • Seebri BreezhalerGlycopyrronii bromidum · inhaler / nebuliser
  • Enurev BreezhalerGlycopyrronii bromidum · inhaler / nebuliser
  • Tovanor BreezhalerGlycopyrronii bromidum · inhaler / nebuliser
  • AMIDIL AmiHalerGlycopyrronii bromidum · inhaler / nebuliser

Same active substance. The strength, the form and whether you need a prescription can differ. Always ask a pharmacist before you switch. Polish medicines in the UK →

💬 Ask about this leaflet

Ask anything about Seebri Breezhaler 44 micrograms inhalation powder (hard capsules). The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.

Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.

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