Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.

Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.

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Oxybutynin hydrochloride 5 mg tablets

⚠ This medicine appears to have been discontinued

The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.

If you were prescribed this medicine, other products containing Oxybutynin hydrochloride may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.

Active substance: Oxybutynin hydrochloride

Source: electronic medicines compendium (emc)
Official leaflet: Read the PIL on emc

What you need to know before you take it

e Oxybutynin hydrochloride tablets Do not take Oxybutynin hydrochloride tablets

  • if you are allergic to oxybutynin hydrochloride or any of the other ingredients of this medicine (listed in section 6) Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
  • if you have a rare muscle illness called 'Myasthenia gravis'
  • if you have glaucoma (increased pressure in the eye, sometimes sudden and painful with blurred vision or loss of vision)
  • if your gut (stomach or intestine) is blocked, perforated or not working properly
  • if you have a severe form of a condition known as 'ulcerative colitis'
  • if you have sudden widening of the colon, which causes abdominal pain, fever or shock known as 'toxic megacolon'
  • if you have a blockage that makes it difficult for you to pass water (urine) Do not take this medicine if any one of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Oxybutynin hydrochloride tablets. Warnings and precautions Talk to your doctor or pharmacist before taking Oxybutynin hydrochloride tablets
  • if you have kidney or liver problems
  • if you have an illness affecting the nerves called 'autonomic neuropathy' (e.g., Parkinson's disease)
  • if you have an overactive thyroid gland (Hyperthyroidism)
  • if you have heart disease or high blood pressure
  • if you have an irregular heartbeat (palpitations, arrythmias) and/or increased or rapid heartbeat
  • if you have an enlarged prostate gland (prostatic hypertrophy)
  • if you have gastro-intestinal disorders or disease called ulcerative colitis
  • if you have indigestion or heart burn caused by a 'hiatus hernia' (where part of your stomach pushes through the diaphragm), gastro-oesophageal reflux and/or you are using medicinal products that can cause or worsen oesophagitis
  • if you have a raised body temperature or fever
  • if you will be taking this medicine in a hot climate Oxybutynin may reduce the amount of saliva resulting in tooth decay or fungal infection of the mouth. Oxybutynin can cause glaucoma (increased pressure in the eye). Please contact your doctor immediately if you suffer any blurred vision, loss of vision or have any pain in the eye. Oxybutynin can cause hallucinations, agitation, confusion or somnolence so that your doctor might consider to monitor you. If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Oxybutynin hydrochloride tablets. Elderly People 65 years of age or older should take Oxybutynin hydrochloride tablets with caution, because of the risk of cognitive impairment and being at a greater risk of occurrence of adverse reactions. Children Children under 5 years of age The use of Oxybutynin hydrochloride tablets is not recommended in children under 5 years of age.

Children 5 years of age or older Oxybutynin hydrochloride tablets should be taken with caution as they may be more sensitive to the effects of the product and at a greater risk of occurrence of adverse reactions. Other medicines and Oxybutynin hydrochloride tablets Please tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. This is because Oxybutynin can affect the way some other medicines work. Also, some other medicines can affect the way Oxybutynin works. In particular, tell your doctor if you are taking any one of the following:

  • Other anticholinergic or antimuscarinic medicines such as some medicines for irritable bowel syndrome, asthma or incontinence, motion sickness or movement disorders associated with Parkinson's disease
  • Medicines used to make you feel sleepy (sedatives)
  • Medicines used to treat nausea and vomiting (prochlorperazine or chlorpromazine)
  • Medicines used to treat certain mental illnesses such as clozapine, phenothiazines haloperidol or benperidol (butyrophenones)
  • Medicines used to treat dementia e. g. donepezil, rivastigmine, galantamine or tacrine (cholinesterase inhibitors)
  • Medicines for depression such as amitriptyline, imipramine or dosulepin ('tricyclic antidepressants')
  • Amantadine used in Parkinson's disease or to treat and prevent some virus infections
  • L-dopa or biperidin used to treat Parkinson's disease
  • Digoxin or quinidine used to treat heart problems
  • Atropine which is used to treat certain types of poisonings, a slow heart rate, some eye conditions or is given during surgery
  • Medicines for stomach and bowel related problems – such as domperidone, metoclopromide, bethanechol
  • Medicines to treat allergic symptoms (antihistamines)
  • CYP3A inhibitor e. g. ketoconazole, itraconazole or fluconazole used to treat fungal infections or erythromycin or other macrolide antibiotics used to treat bacterial infections Oxybutynin hydrochloride tablets with alcohol If you drink alcohol while using Oxybutynin hydrochloride tablets, you may become very drowsy. Pregnancy and breastfeeding If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. While breast-feeding, small amounts may pass into mothers' milk. Breastfeeding while using this medicine is therefore not recommended. Driving and using machines You may feel drowsy or have blurred vision while you are taking this medicine, especially in combination with alcohol. If this happens, do not drive or use any tools or machines. Oxybutynin hydrochloride tablets contain lactose If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

How to take it

Oxybutynin hydrochloride tablets Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Taking this medicine

  • Take this medicine by mouth
  • Swallow the tablets with a glass of water
  • Do not give this medicine to children under 5 years old
  • If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor The recommended dose is Adults You should follow your doctor's instructions closely. In general the dosage will begin with one Oxybutynin hydrochloride 2.5 mg tablet three times daily, later to be increased to a dosage between 10 and 15 mg per day, possibly to a maximum of 20 mg, to be taken in 2 to 3 (maximum 4) doses. Elderly The dose must be determined individually for each patient by starting with an initial dosage of 2.5 mg twice daily. Then the lowest possible effective dose should be chosen. Children aged 5 years and older The initial dosage is 2.5 mg twice daily. The maximum dosage adjusted to bodyweight (0.3-0.4 mg/kg per day) is given in the table below: Age

Dosage

5 – 9 years

2.5 mg three times daily

9 – 12 years

5 mg twice daily

older than 12 years

5 mg three times daily

If you feel that the effects of Oxybutynin hydrochloride tablets are too strong or too weak, ask your doctor or pharmacist for advice. Oxybutynin hydrochloride tablets should not be used in children under the age of 5. Taking Oxybutynin hydrochloride tablets Your doctor will tell you for how long Oxybutynin hydrochloride tablets must be used. It is recommended that the effect should be re-assessed after 4 to 6 weeks, because normal bladder function may have returned.

Taking Oxybutynin hydrochloride tablets with food or drink The tablets should be taken on an empty stomach with plenty of water. If irritation of the stomach occurs, the tablets may be taken during a meal or with some milk. If you take more Oxybutynin hydrochloride tablets than you should If you take more Oxybutynin hydrochloride tablets than you should, tell a doctor or go to a hospital casualty department straight away. Take the medicine pack with you. This is so the doctor knows what you have taken. Taking too much Oxybutynin hydrochloride tablets can be very dangerous. You may become very restless or excited, flushed or get dizzy or light-headed. Your heartbeat may become very fast, uneven, or forceful or your blood pressure drops. You may get breathing problems or numbness or go into a coma. If you forget to take Oxybutynin hydrochloride tablets If you forget a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose. If you stop taking Oxybutynin hydrochloride tablets Keep taking Oxybutynin until your doctor tells you to stop. Do not stop taking Oxybutynin just because you feel better. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 4. Possible side effects Like all medicines, this medicine can cause side effects, although not everyone gets them. Stop taking Oxybutynin hydrochloride tablets and see a doctor or go to a hospital immediately if: Frequency not known (frequency cannot be estimated from the available data)

  • You have an allergic reaction, the signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
  • You may feel reduced sweating, leading to overheating in hot environments Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days: Very common (may affect more than 1 in 10 people)

Common (may affect up to 1 in 10 people)

  • Constipation
  • Nausea
  • Dry mouth
  • Dry skin
  • Headache
  • Somnolence (feeling drowsy or sleepy)
  • Dizziness
  • Blurring of vision
  • Dry eyes
  • Diarrhoea
  • Being sick (vomiting)
  • Flushing especially in children
  • Confusion
  • inability to completely empty the bladder (urinary retention)
  • A forceful heartbeat that may be rapid or irregular

Uncommon (may affect up to 1 in 100 people)

  • Stomach pain
  • Loss of appetite (anorexia)
  • Difficulty in swallowing (dysphagia)

Frequency not known (frequency cannot be estimated from the available data)

  • Increased pressure in the eyes, sometimes sudden and painful with blurred vision or loss of vision (glaucoma)
  • Indigestion or heartburn (acid reflux)
  • Urinary tract infection
  • Heat stroke
  • Difficulty passing water (urine)
  • Agitation
  • Anxiety
  • Becoming dependent on Oxybutynin tablets if there is a history of drug or substance abuse
  • Feeling excessively suspicious and distrustful of others
  • Seeing or hearing things that are not there (hallucinations)
  • Drowsiness
  • Nightmares
  • Fits (convulsions)
  • Depression
  • Increased heartbeat (tachycardia)
  • Irregular heartbeat (arrythmia)
  • Dilatation of pupil (mydriasis)
  • Itchy, lumpy rash (urticaria)
  • Absence of sweating (hypohidrosis)
  • Skin that is more sensitive to the sun (photosensitivity)
  • Disorientation
  • Cognitive disorders
  • Nosebleed
  • Angioedema
  • Muscle weakness, pain or cramps

Additional side effects in children Children are at higher risk of the effects.

Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting

Possible side effects

you can help provide more information on the safety of this medicine.

How to store it

Oxybutynin hydrochloride tablets Do not store above 25°C. Store in the original pack. Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date refers to the last day of that month. Always hand over any left-over medicine to the pharmacist for safe disposal. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.

Contents of the pack and other information

What Oxybutynin hydrochloride 2.5 mg / 3 mg / 5 mg tablets contain

  • Each Oxybutynin hydrochloride 2.5 mg Tablet contains 2.5 mg oxybutynin hydrochloride.
  • Each Oxybutynin hydrochloride 3 mg Tablet contains 3 mg oxybutynin hydrochloride.
  • Each Oxybutynin hydrochloride 5 mg Tablet contains 5 mg oxybutynin hydrochloride. The other ingredients are: Crospovidone, microcrystalline cellulose, lactose monohydrate and magnesium stearate. What Oxybutynin hydrochloride 2.5 mg / 3 mg / 5 mg tablets look like and contents of the pack Oxybutynin hydrochloride is supplied as white circular flat bevelled edge tablets. Oxybutynin hydrochloride 2.5 mg tablet is marked '2.5' on one side and plain on the other side. Oxybutynin hydrochloride 3 mg tablet is scored on one side and blank on the other side. Oxybutynin hydrochloride 5mg tablet is marked '5' on one side and marked with a scoreline on the other side. The tablets are supplied in blister packs of 7, 28, 56 or 84 tablets. Not all pack sizes may be marketed. Marketing Authorisation Holder Morningside Healthcare Ltd Unit C, Harcourt Way, Leicester, LE19 1WP, UK Manufacturer FAL Duiven Dijkgraaf, 6921, RK Duiven, The Netherlands Morningside Pharmaceuticals Ltd. 5 Pavilion Way, Loughborough LE11 5 GW, UK This leaflet was last revised in September 2023.

M0200LAMUKNA-P1-005

Frequently asked questions about Oxybutynin hydrochloride 5 mg tablets

How do I take Oxybutynin hydrochloride 5 mg tablets?

Oxybutynin hydrochloride 5 mg tablets comes as tablet containing 5mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.

What is the active substance in Oxybutynin hydrochloride 5 mg tablets?

The active substance in Oxybutynin hydrochloride 5 mg tablets is oxybutynin hydrochloride.

Are there equivalent medicines to Oxybutynin hydrochloride 5 mg tablets?

Medicines with the same active substance, strength and form include: Ditropan 5mg Tablets, Lyrinel XL 5 mg prolonged release tablet, Oxybutynin Hydrochloride 5mg Tablets. In total there are 5 equivalent products. They are interchangeable only if your prescriber or pharmacist says so.

Where does this information come from?

This leaflet reproduces the patient information leaflet approved for Oxybutynin hydrochloride 5 mg tablets, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.

Can I get Oxybutynin hydrochloride 5 mg tablets without a prescription?

Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.

About this leaflet

The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.

Medical disclaimer: This page is for information only and does not replace advice from your doctor or pharmacist. Always read the leaflet supplied with your medicine. If you are unwell, call NHS 111; in an emergency, call 999.

Medicines with the same active substance: Oxybutynin hydrochloride (16 medicines)
See every medicine containing this substance, or browse the full A–Z of active substances.
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
Technical information intended for healthcare professionals (doctors and pharmacists). The Summary of Product Characteristics (SmPC) is the official document approved by the MHRA/EMA. It does not replace the patient leaflet or a doctor’s advice.

4.1. Therapeutic indications

Oxybutynin hydrochloride is indicated for urinary incontinence, urgency and frequency in unstable bladder, whether due to neurogenic bladder disorders (detrusor hyperreflexia) in conditions such as multiple sclerosis and spina bifida, or to idiopathic detrusor instability (motor urge incontinence).

Paediatric population

Oxybutynin hydrochloride is indicated in children over 5 years of age for:

- Urinary incontinence, urgency and frequency in unstable bladder conditions due to idiopathic overactive bladder or neurogenic bladder disorders (detrusor overactivity).

4.2. Posology and method of administration

Posology

Adults: The dosage should be determined individually, with an initial dose of 2.5 mg three times daily. Thereafter, the lowest effective dose should be selected. The daily dose may vary between 10 and 15 mg per day (maximum dose is 20 mg per day) divided into 2-3 (max. 4) doses.

Elderly: The elimination half-life is increased in the elderly. Therefore, a dose of 2.5mg twice a day, particularly if the patient is frail, is likely to be adequate. This dose may be titrated upwards to 5mg two times a day to obtain a clinical response provided the side effects are well tolerated.

Children (under 5 years of age): The safety and efficacy of oxybutynin hydrochloride in children below 5 years of age has not been established. No data are available.

Children (over 5 years of age): The dosage should be determined individually, with an initial dose of 2.5 mg twice daily. Thereafter, the lowest effective dose should be selected. The maximum dose, which is related to body weight (0,3 - 0,4 mg / kg / day), is expressed in the following table:

Age

Dosage

5-9 years

2.5 mg three times daily

9-12 years

5 mg 2 times daily

Over 12 years

5 mg three times daily

Neurogenic bladder instability: the usual dose is 2.5mg twice a day. This dose may be titrated upwards to 5mg two or three times a day to obtain a clinical response provided the side effects are well tolerated. Nocturnal enuresis: the usual dose is 2.5 mg twice a day. This dose may be titrated upwards to 5mg two or three times a day to obtain a clinical response provided the side effects are tolerated. The last dose should be given before bedtime.

The tablets can be taken on an empty stomach.

The tablet should be swallowed whole, with appropriate amount of water.

Method of administration

The tablets have to be swallowed with plenty of fluid and may be taken on an empty stomach. If gastric irritation occurs the tablets may also be taken during meals or with some milk.

4.3. Contraindications

Hypersensitivity to the active substance(s) or to any of the excipients listed in section 6.1.

Narrow-angle glaucoma or shallow anterior chamber.

Myasthenia gravis.

Gastrointestinal obstructive disorders including paralytic ileus, intestinal atony.

Patients with severe ulcerative colitis.

Patients with toxic megacolon.

Patients with bladder outflow obstruction where urinary retention may be precipitated.

4.4. Special warnings and precautions for use

Oxybutynin should be used with caution in patients with Parkinson's disease who are at greater risk of occurrence of adverse reactions to the product and in patients with autonomic neuropathy (such as those with Parkinson's disease), severe gastro- intestinal motility disorders, hepatic or renal impairment.

Anticholinergic medicinal products may decrease gastrointestinal motility and should be used with caution in patients with gastrointestinal obstructive disorders, intestinal atony and ulcerative colitis.

Oxybutynin may aggravate cognitive disorders, symptoms of prostatic hypertrophy and tachycardia (thus be cautious in case of hyperthyroidism, congestive heart failure, cardiac arrhythmia, coronary heart disease, hypertension).

Anticholinergic CNS effects (such as hallucinations, agitation, confusion, somnolence) have been reported. Monitoring recommended, particularly in first few months after initiating therapy or increasing the dose. If anticholinergic CNS effects develop, termination of treatment or dose reduction may be considered.

Since oxybutynin can cause narrow-angle glaucoma, patients should be advised to contact a physician immediately if they are aware of a sudden loss of visual acuity or ocular pain.

Oxybutynin may reduce salivary secretions which could result in dental caries, parodontosis or oral candidiasis.

Anticholinergic medicinal products should be used with caution in patients who have hiatus hernia/gastro-oesophageal reflux and/or who are concurrently taking medicinal products (such as bisphosphonates) that can cause or exacerbate oesophagitis.

When oxybutynin is used in high environmental temperatures, this can cause heat prostration due to decreased sweating.

Elderly

Anticholinergic medicinal products should be used with caution in elderly patients due to the risk of cognitive impairment. They also have a higher risk of occurrence of adverse reactions to the product.

Paediatric population

The use of oxybutynin in children under 5 years of age is not recommended; it has not been established whether oxybutynin can be safely used in this age group.

There is limited evidence supporting the use of oxybutynin in children with monosymptomatic nocturnal enuresis (not related to detrusor overactivity). In children over 5 years of age, oxybutynin hydrochloride should be used with caution as they may be more sensitive to the effects of the product, particularly the CNS and psychiatric adverse reactions.

Patients with rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption should not take this medicine.

4.5. Interaction with other medicinal products and other forms of interaction

Care should be taken if other anticholinergic agents are administered together with Oxybutynin hydrochloride, as potentiation of anticholinergic effects could occur.

The anticholinergic activity of oxybutynin is increased by concurrent use of other anticholinergics or medicinal products with anticholinergic activity, such as amantadine and other anticholinergic antiparkinsonian medicinal products (e.g. biperiden, levodopa), antihistamines, antipsychotics (e.g. phenothiazines, butyrophenones, clozapine), quinidine, digitalis, tricyclic antidepressants, atropine and related compounds like atropinic antispasmodics and dipyridamole.

By reducing gastric motility, oxybutynin may affect the absorption of other drugs. Oxybutynin is metabolised by cytochrome P450 isoenzyme CYP 3A4. Concomitant administration with a CYP 3A4 inhibitor can inhibit oxybutynin metabolism and increase oxybutynin exposure.

Oxybutynin, as an anticholinergic agent, may antagonize the effect of prokinetic therapies.

Concomitant use with cholinesterase inhibitors may result in reduced cholinesterase inhibitor efficacy.

Patients should be informed that alcohol may enhance the drowsiness caused by anticholinergic agents such as oxybutynin (see section 4.7).

4.6. Fertility, pregnancy and lactation

Pregnancy: There are no adequate data from the use of oxybutynin in pregnant women. Animal studies are insufficient with respect to effects on pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3). The potential risk for humans is unknown. Oxybutynin hydrochloride should not be used during pregnancy unless clearly necessary.

Breast-feeding: When oxybutynin is used during lactation, a small amount is excreted in mother's milk. Breast feeding while using Oxybutynin is therefore not recommended.

4.7. Effects on ability to drive and use machines

Oxybutynin may cause drowsiness or blurred vision. Patients should be cautioned regarding activities requiring mental alertness such as driving, operating machinery or performing hazardous work while taking this drug.

4.8. Undesirable effects

Like all medicines, oxybutynin can cause undesirable effects, although not everybody gets them. The frequency of possible undesirable effects listed below are currently defined as:

Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).

ADVERSE REACTIONS REPORTED

System Organ Class

Frequency

Adverse Reaction (MedDRA Terms)

Infections and Infestations

Not known

urinary tract infection

Immune System Disorders

Not known

hypersensitivity

Psychiatric Disorders

Common

confusional state

Not known

agitation, anxiety, cognitive disorders in elderly, hallucinations, nightmares, paranoia, symptoms of depression, dependence to oxybutynin (in patients with history of drug or substance abuse)

Nervous System Disorders

Very common

dizziness, headache, somnolence

Not known

cognitive disorders, convulsions, drowsiness, disorientation

Eye Disorders

Very common

vision blurred

Common

dry eyes

Not known

angle closure glaucoma, increased intraocular pressure, mydriasis

Cardiac Disorders

Not known

arrhythmia, tachycardia

Common

palpitation

Vascular Disorders

Common

flushing (which may be more marked in children)

Respiratory, thoracic, and mediastinal disorders

Not known

epistaxis

Gastrointestinal Disorders

Very common

constipation, dry mouth, nausea

Common

diarrhoea, vomiting

Uncommon

abdominal discomfort, anorexia, decreased appetite, dysphagia

Not known

gastroesophageal reflux, pseudoobstruction in patients at risk (elderly or patients with constipation and treated with other drugs that decrease intestinal motility)

Skin and Subcutaneous Tissue Disorders

Very common

dry skin

Not known

angioedema, hypohidrosis, rash, urticaria, photosensitivity

Musculoskeletal and connective tissue disorders

Not known

Muscle disorders manifested as muscle weakness, myalgia and/ or muscle spasms

Renal and Urinary Disorders

Common

urinary retention

Not known

difficulty in micturition

Injury, Poisoning and Procedural Complications

Not known

heat stroke

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system using the Yellow Card Scheme, at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

4.9. Overdose

Symptoms of intoxication:

The symptoms of overdosage with oxybutynin progress from an intensification of the usual side effects of CNS disturbances (from restlessness and excitement to psychotic behaviour), circulatory changes (flushing, fall in blood pressure, circulatory failure, etc.), respiratory failure, paralysis and coma.

Management:

Measures to be taken are:

1) Immediate gastric lavage

2) Physostigmine by slow intravenous injection

Adults: 0.5 to 2.0 mg of physostigmine by slow intravenous administration. Repeat after 5 minutes, if necessary up to a maximum total dose of 5mg.

Paediatric population: 30 µg/kg of physostigmine by slow intravenous administration. Repeat after 5 minutes, if necessary up to a maximum total dose of 2mg.

Fever should be treated symptomatically with tepid sponging or ice packs.

In pronounced restlessness or excitation, diazepam 10mg may be given by intravenous injection, tachycardia may be treated by intravenous injection of propranolol and urinary retention can be managed by bladder catheterisation.

In the event of progression of the curare- like effects to paralysis of the respiratory muscles, mechanical ventilation will be required.

💬 Ask about this leaflet

Ask anything about Oxybutynin hydrochloride 5 mg tablets. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.

Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.

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