Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Menadiol Diphosphate Tablets 10mg
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Menadiol sodium diphosphate may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
What it is and what it is used for
FOR Menadiol diphosphate is a man-made form of vitamin K, also known as vitamin K4. Vitamin K is involved in the process of blood clotting and a deficiency of vitamin K can lead to unwanted bleeding. Menadiol Diphosphate 10mgTablets are used to treat or prevent excessive bleeding in certain situations, for example after surgery and in some forms of jaundice when the body may be unable to absorb sufficient vitamin K from the diet.
What you need to know before you take it
E MENADIOL Do not take Menadiol Diphosphate 10mg Tablets if: •
You know that you are allergic to menadiol diphosphate or any of the other ingredients in this product.
Menadiol Diphosphate 10mg Tablets should not be given to babies or very young infants.
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If you need any other medical treatment or surgery whilst taking Menadiol Diphosphate 10mg Tablets, remember to tell the doctor or dentist treating you that you are taking this medicine. Other medicines and Menadiol Please tell your doctor or pharmacist if you are taking, or have recently taken, any other medicines. This includes medicines obtained without a prescription. In particular, tell your doctor or pharmacist if you are taking tablets to thin the blood (eg. warfarin) which have an opposite effect to that of menadiol diphosphate. Pregnancy and breast feeding Do not take Menadiol Diphosphate 10mg Tablets if you are pregnant (or think you may be) unless your doctor has told you that you can. It is particularly important not to take Menadiol Diphosphate 10mg Tablets in late pregnancy or during labour. Menadiol diphosphate is not recommended whilst breastfeeding. Ask your doctor or pharmacist for advice before taking any medicine. Driving and using machines Menadiol Diphosphate 10mg Tablets should not affect your ability to drive or use machines. These tablets contain lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
How to take it
MENADIOL DIPHOSPHATE 10mg TABLETS Always take this medicine exactly as described in this leaflet or as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Menadiol Diphosphate 10mg Tablets should be taken by mouth. The usual adult dose is one to four tablets daily, whilst children may be given from one-half of a tablet up to two tablets daily. The tablet can be divided into equal doses. If you take more Menadiol Diphosphate 10mg Tablets than you should If you accidentally take too many tablets, or someone else takes your medicine, you should tell your doctor at once or contact your nearest accident and emergency department. Show any left-over medicines or the empty packet to the doctor.
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If you forget to take Menadiol Diphosphate 10mg Tablets If you forget to take a dose at the right time, take it as soon as you remember unless your next dose is due within a couple of hours. In this case you should skip the missed dose and go back to your regular dosing schedule. Do not take double doses. The same applies if you forget to give a dose to your child at the right time. If you have any further questions on the use of this product ask your doctor or pharmacist.
Possible side effects
Like all medicines Menadiol Diphosphate 10mg Tablets can cause side-effects, although not everybody gets them. All medicines can cause allergic reactions although serious allergic reactions are very rare. Any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body) should be reported to a doctor immediately. It is very unlikely that you (or your child) will suffer any side-effects from taking Menadiol Diphosphate 10mg Tablets. Very occasionally the use of these tablets can cause destruction of the red blood cells, leading to anaemia and jaundice. Anaemia can cause tiredness and paleness, and jaundice can cause yellowing of the skin and eyes. If you notice any of these please tell your doctor straight away. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:www.mhra.gov.uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.
How to store it
MENADIOL DIPHOSPHATE 10mg TABLETS Keep this medicine out of the sight and reach of children – preferably in a locked cupboard or medicine cabinet.
Do not use this medicine after the expiry date which is stated on the tablet container after EXP. The expiry date refers to the last day of that month. , Store below 30 ̊C and keep the tablets in their original container to protect from light. Do not use this medicine if you notice the appearance has changed in any way.
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If your doctor decides to stop your treatment, return any unused medicine to the pharmacist. Only keep it if your doctor tells you to. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Contents of the pack and other information
What these tablets contain The active substance is menadiol diphosphate. Each tablet contains 12.63mg of menadiol sodium diphosphate, which is equivalent to 10mg of the active ingredient menadiol diphosphate. The other ingredients are lactose monohydrate, pregelatinised starch, talc and magnesium stearate.
What Menadiol Diphosphate 10mg Tablets look like and contents of pack The tablets are 9.00 mm, round, white to pale pink with CL 1L3 debossed on one face and a single break bar on the other. Menadiol Diphosphate 10mg Tablets are supplied in plastic containers of 100 tablets. Marketing Authorisation Holder Alliance Pharmaceuticals Ltd, Avonbridge House, Bath Road, Chippenham, Wiltshire, SN15 2BB, UK. Manufacturer Penn Pharmaceutical Services Limited, Tafarnaubach Industrial Estate, Tredegar, Gwent, NP22 3AA. This leaflet was last revised in April 2018
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Frequently asked questions about Menadiol Diphosphate Tablets 10mg
How do I take Menadiol Diphosphate Tablets 10mg?
Menadiol Diphosphate Tablets 10mg comes as tablet containing 10mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Menadiol Diphosphate Tablets 10mg?
The active substance in Menadiol Diphosphate Tablets 10mg is menadiol sodium diphosphate.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Menadiol Diphosphate Tablets 10mg, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Menadiol Diphosphate Tablets 10mg without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: menadiol sodium diphosphate
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
For the treatment of haemorrhage or threatened haemorrhage associated with a low blood level of prothrombin or factor vii. The main indication is obstructive jaundice (before and after surgery).
4.2. Posology and method of administration
Menadiol Diphosphate 10mg Tablets are for oral administration.
Adults
Usual therapeutic dose: 10-40mg daily
Children
If, on the recommendation of a physician, a children's dosage is required, it is suggested that 5-20mg daily be given.
The elderly
Recommendations for use in the elderly do not differ from those for other adults.
4.3. Contraindications
Administration to neonates, infants or to mothers in the pre- and post-natal periods. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
4.4. Special warnings and precautions for use
None.
4.5. Interaction with other medicinal products and other forms of interaction
Large doses of menadiol sodium diphosphate may decrease patient sensitivity to anticoagulants.
4.6. Fertility, pregnancy and lactation
There is evidence of hazard if menadiol sodium diphosphate is used in human pregnancy. It is known to be associated with a small risk of haemolytic anaemia, hyperbilirubinaemia and kernicterus in the infant if administered to the mother in late pregnancy or during labour. Menadiol sodium diphosphate is therefore contra-indicated during late pregnancy.
4.7. Effects on ability to drive and use machines
None known.
4.8. Undesirable effects
Menadiol sodium diphosphate may induce haemolysis (especially in the newborn infant) in the presence of erythrocyte glucose-6-phosphate dehydrogenase deficiency or low concentrations of alpha-tocopherol in the blood.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
4.9. Overdose
No information is available.
💬 Ask about this leaflet
Ask anything about Menadiol Diphosphate Tablets 10mg. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.