Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Duac Once Daily 10 mg/g + 30 mg/g Gel
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Benzoyl peroxide, Clindamycin phosphate may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
What it is and what it is used for
for
DUAC ONCE DAILY GEL contains two medicines: clindamycin and benzoyl peroxide. DUAC ONCE DAILY GEL belongs to a group of medicines known as 'anti-acne preparations'. DUAC ONCE DAILY GEL is used for treating mild to moderate acne on your skin.
- Clindamycin is an antibiotic which stops the bacteria involved in acne from reproducing.
- Benzoyl peroxide reduces blackheads and whiteheads. It also kills the bacteria involved in acne. Used together in DUAC ONCE DAILY GEL, these work by:
- fighting the bacteria that can cause acne
- treating existing blackheads, whiteheads, and spots
- lowering the number of red, inflamed acne spots DUAC ONCE DAILY GEL is for use by adults and adolescents aged twelve years or over.
2.
What you need to know before you take it
e DUAC ONCE DAILY GEL
Do not use DUAC ONCE DAILY GEL:
- if you are allergic to clindamycin, lincomycin, benzoyl peroxide or any of the other ingredients of DUAC ONCE DAILY GEL (listed in Section 6) Do not use DUAC ONCE DAILY GEL if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before you start using DUAC ONCE DAILY GEL. Warnings and precautions Talk to your doctor or pharmacist before using DUAC ONCE DAILY GEL. • •
Only use DUAC ONCE DAILY GEL on your skin. Keep it away from areas like your eyes, lips, mouth, or inside your nose. Do not use the gel on any irritated areas of your skin. For example, if you have cuts, grazes, sunburn, or broken skin.
➔ If you accidently get DUAC ONCE DAILY GEL in your eyes, mouth, or inside your nose rinse with plenty of water. • •
• • • •
Do not use too much DUAC ONCE DAILY GEL on sensitive areas of skin. Most patients will experience some skin redness and peeling during the first few weeks of treatment. If your skin becomes irritated, you may need to use an oil-free moisturiser, use DUAC ONCE DAILY GEL less often, or stop using it for a short period to allow your skin to recover and then re-start treatment. Stop treatment and see your doctor if skin irritation is severe (severe redness, dryness, itching, stinging or burning) or does not improve. Try not to let DUAC ONCE DAILY GEL come into contact with coloured fabrics, including clothing, towels, bed linen, furniture or carpeting. DUAC ONCE DAILY GEL can bleach these materials. DUAC ONCE DAILY GEL may bleach hair. DUAC ONCE DAILY GEL can make your skin more sensitive to the harmful effects of the sun. Avoid the use of sunbeds/lamps and minimise the time you spend in the sun. You should use a sunscreen and wear protective clothing while using DUAC ONCE DAILY GEL.
Check with your doctor or pharmacist before using this medicine if:
- you have ever had any of the following gut problems: 'regional enteritis', 'ulcerative colitis', or 'antibiotic-associated colitis'. •
If you develop stomach cramps or diarrhoea that does not improve or is severe, stop using DUAC ONCE DAILY GEL and contact your doctor immediately. Antibiotics may cause a condition that results in severe diarrhoea and stomach cramps although this is unlikely to happen with antibiotics applied to the skin.
- If you have recently used other clindamycin or erythromycin containing medicines, there is an increased chance that DUAC ONCE DAILY GEL will not work as well as it should. ➔ Tell your doctor or pharmacist if you have used any other clindamycin or erythromycin containing medicines recently. Children Do not give this medicine to children under twelve years. It is not known if it works or if it is safe for them. Other medicines and DUAC ONCE DAILY GEL Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines. Tell your doctor or pharmacist if you are using any of the following:
- any other acne treatments including antibiotics used on your skin
- medicated or 'abrasive' soaps and cleansers
- soaps or cosmetics that have a strong drying effect
- products which contain large amounts of alcohol or 'astringents' This is because when used together with DUAC ONCE DAILY GEL, they may irritate your skin over time. DUAC ONCE DAILY GEL may make some acne medicines less effective when used at the same time. This includes:
- Some acne medicines that are applied to the skin which contain tretinoin, isotretinoin or tazarotene ➔ Tell your doctor or pharmacist if you are also using one of these medicines. You may need to use the two products at different times of the day (e.g. one in the morning and the other in the evening). Using other acne medicines at the same time as DUAC ONCE DAILY GEL can increase the risk of skin irritation. ➔ Stop treatment and see your doctor if skin irritation becomes severe (severe redness, dryness, itching, stinging or burning).
•
DUAC ONCE DAILY GEL should not be used at the same time as erythromycin containing medicines.
- Applying DUAC ONCE DAILY GEL at the same time as medicines such as dapsone and sulfacetamide can cause a temporary colour-change of skin or facial hair (yellow/orange colour). This will not be permanent.
- One of the medicines in DUAC ONCE DAILY GEL can affect how certain general anaesthesia medicines work (called "neuromuscular blocking agents"). ➔ Tell your doctor or pharmacist if you are going to have surgery. If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before using DUAC ONCE DAILY GEL. Pregnancy, breast-feeding and fertility There is only limited information about the safety of DUAC ONCE DAILY GEL in pregnant women. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine. Your doctor will consider the benefit to you and the risk to your baby of using DUAC ONCE DAILY GEL while you're pregnant. It is not known whether the ingredients of DUAC ONCE DAILY GEL can pass into breast milk. One of the medicines in DUAC ONCE DAILY GEL is clindamycin. When clindamycin is taken by mouth or injection, it may pass into breast milk. If you are breast-feeding, you must check with your doctor before you use DUAC ONCE DAILY GEL. Do not use DUAC ONCE DAILY GEL on your breast if you are breast-feeding. 3.
How to take it
DUAC ONCE DAILY GEL
Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. • • •
Use DUAC ONCE DAILY GEL once a day in the evening. It may take 2-5 weeks before you see the effect of DUAC ONCE DAILY GEL. Do not use for more than 12 weeks at one time. Your doctor will tell you how long your treatment will last.
How to apply DUAC ONCE DAILY GEL 1. Completely remove any make-up. 2. Wash the affected area of skin well. Then rinse with warm water and gently pat dry. 3. Put a thin film of gel on the entire area of affected skin, using your fingertips. 4. Apply to all of the areas of your skin which have acne, not just to the individual spots. If the gel does not rub into your skin easily, you are using too much.
- For your face only, use an amount of gel from the tube which reaches from the tip of your finger to the first joint (the first crease on your finger). This is a 'finger tip'.
- For your face and back, use two and a half 'finger tips' in total. 5. If you get a lot of dryness or skin peeling, you can use an oil-free, fragrance free, hypoallergenic moisturiser, use DUAC ONCE DAILY GEL less frequently or stop treatment for a short period, to allow your skin to adjust to the treatment. This medicine may not work properly if it is not applied every day. 6. Wash your hands after using the gel. 7. After it has dried, you can use a non-greasy make-up. Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
If you use more DUAC ONCE DAILY GEL than you should
- Take care not to apply too much. Applying too much gel or applying it more frequently will not help your spots clear up more quickly, and may cause skin irritation. If this does happen, use the gel less often, or stop using it for a few days and then start again. If you accidentally swallow DUAC ONCE DAILY GEL
- If you do accidentally swallow the gel, seek medical advice. You may get symptoms similar to when you take antibiotics by mouth (an upset stomach). If you forget to use DUAC ONCE DAILY GEL
- Do not use a double dose to make up for forgotten individual doses.
- Apply the next dose at the usual time. Don't stop DUAC ONCE DAILY GEL without advice Don't use the gel for more than 12 weeks at one time, without talking to your doctor. Use DUAC ONCE DAILY GEL for as long as your doctor recommends. Don't stop unless your doctor advises you to. It is important to continue to use the gel as prescribed by your doctor. If you stop too soon, your acne may return. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 4.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop using DUAC ONCE DAILY GEL and see a doctor straight away if you notice any of the following serious side effects – you may need urgent medical treatment:
- signs of an allergic reaction (such as swelling of your face, eyes, lips or tongue, nettle rash or difficulty breathing, collapse)
- severe or prolonged diarrhoea, or abdominal cramps
- severe burning, peeling, or itching Other possible side effects: If you notice any of these side effects, try using DUAC ONCE DAILY GEL less often, or stop using it for one or two days and then start again. Very common side effects (at least 1 in 10 people are affected) At site of application:
- Skin burning sensation, peeling, itching, dry skin
- Redness of your skin, especially during the first few weeks of use These side effects are generally mild. Common side effects (less than 1 in 10 people are affected) •
Headache
At the site of application:
- Sensitivity to sunlight, skin pain
- Red, itchy skin, rash (dermatitis)
Uncommon side effects (less than 1 in 100 people affected) At the site of application:
- Tingling (paraesthesia), worsening of acne Other side effects Other side effects have occurred in a very small number of people but their exact frequency is unknown: • •
Allergic reactions Inflammation of the intestine, diarrhoea, including bloody diarrhoea, stomach pain
At the site of application:
- Skin reactions, discoloration of the skin
- Raised itchy rash (hives) Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
5.
How to store it
DUAC ONCE DAILY GEL
Keep this medicine out of the sight and reach of children. Pharmacist: Store in a refrigerator (2 °C-8 °C). Do not freeze. Patient: After you have received DUAC ONCE DAILY GEL from the pharmacist, do not store it above 25 °C, and discard after 2 months. Do not use this medicine after the expiry date which is stated on the tube and carton (after "Exp:"). The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6.
Contents of the pack and other information
What DUAC ONCE DAILY GEL contains • •
The active substances are: clindamycin and hydrous benzoyl peroxide. 1 g of gel contains 10 mg (1 % w/w) clindamycin as clindamycin phosphate and 30 mg (3 % w/w) anhydrous benzoyl peroxide as hydrous benzoyl peroxide. The other ingredients are: carbomer, dimeticone, disodium lauryl sulfosuccinate, disodium edetate, glycerol, silica (colloidal hydrated), poloxamer 182, purified water and sodium hydroxide
What DUAC ONCE DAILY GEL looks like and contents of the pack DUAC ONCE DAILY GEL is a white to slightly yellow-coloured gel and is supplied in tubes of 30 g and 60 g. Not all pack sizes may be marketed
Marketing Authorisation Holder and Manufacturer Marketing Authorisation Holder: GlaxoSmithKline UK Limited, 79 New Oxford Street London WC1A 1DG United Kingdom Manufacturer: Glaxo Operations UK Ltd, Harmire Road, Barnard Castle, Co. Durham, DL12 8DT, UK Or
GlaxoSmithKline Trading Services Limited 12 Riverwalk, Citywest Business Campus Dublin 24, Ireland Other formats: To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge: 0800 198 5000 (UK Only) Please be ready to give the following information: Product name
Duac Once Daily 10 mg/g + 30 mg/g gel
Reference number
19494/0251
This is a service provided by the Royal National Institute of Blind People. This leaflet was last revised in March 2025. Trade marks are owned by or licensed to the GSK group of companies. ©2025 GSK group of companies or its licensor
Frequently asked questions about Duac Once Daily 10 mg/g + 30 mg/g Gel
How do I take Duac Once Daily 10 mg/g + 30 mg/g Gel?
Duac Once Daily 10 mg/g + 30 mg/g Gel comes as gel containing 10mg / 30mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Duac Once Daily 10 mg/g + 30 mg/g Gel?
The active substance in Duac Once Daily 10 mg/g + 30 mg/g Gel is benzoyl peroxide, clindamycin phosphate.
Are there equivalent medicines to Duac Once Daily 10 mg/g + 30 mg/g Gel?
Medicines with the same active substance, strength and form include: Clindamycin + Benzoyl Peroxide 10mg/g + 30mg Gel. They are interchangeable only if your prescriber or pharmacist says so.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Duac Once Daily 10 mg/g + 30 mg/g Gel, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Duac Once Daily 10 mg/g + 30 mg/g Gel without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: benzoyl peroxide, clindamycin phosphate
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
Duac Once Daily 10 mg/g + 30 mg/g Gel is indicated for the topical treatment of mild to moderate acne vulgaris, particularly inflammatory lesions, in adults and adolescents aged 12 years and above (see sections 4.4 and 5.1).
Consideration should be given to official guidance on the appropriate use of antibacterial agents.
4.2. Posology and method of administration
For cutaneous use only.
Posology
Adults and Adolescents (aged 12 years and above)
Duac Once Daily 10 mg/g + 30 mg/g Gel should be applied once daily in the evening, to the entire affected area.
Patients should be advised that excessive application will not improve efficacy, but may increase the risk of skin irritation. If excessive dryness or peeling occurs, frequency of application should be reduced or application temporarily interrupted (see section 4.4).
The safety and efficacy of Duac Once Daily 10 mg/g + 30 mg/g Gel has not been studied beyond 12 weeks in acne vulgaris clinical trials. Treatment with Duac Once Daily 10 mg/g + 30 mg/g Gel should not exceed more than 12 weeks of continuous use.
Paediatric population
The safety and efficacy of Duac Once Daily 10 mg/g + 30 mg/g Gel has not been established in children under 12 years of age, therefore Duac Once Daily 10 mg/g + 30 mg/g Gel is not recommended for use in this population.
Elderly patients
No specific recommendations.
Method of administration
Duac Once Daily 10 mg/g + 30 mg/g Gel should be applied in a thin film after washing gently with a mild cleanser and fully drying. If the gel does not rub into the skin easily, too much is being applied.
Hands should be washed after application.
4.3. Contraindications
Duac Once Daily 10 mg/g + 30 mg/g Gel must not be administered to patients with known hypersensitivity to:
- clindamycin
- lincomycin
- benzoyl peroxide
- any of the excipients in the formulation listed in section 6.1
4.4. Special warnings and precautions for use
Contact with the mouth, eyes, lips, other mucous membranes or areas of irritated or broken skin should be avoided. Application to sensitive areas of skin should be made with caution. In case of accidental contact, rinse well with water.
Duac Once Daily 10 mg/g + 30 mg/g Gel should be used with caution in patients with a history of regional enteritis or ulcerative colitis, or a history of antibiotic-associated colitis.
Duac Once Daily 10 mg/g + 30 mg/g Gel should be used with caution in atopic patients, in whom further skin drying may occur.
During the first weeks of treatment, an increase in peeling and reddening will occur in most patients. Depending upon the severity of these side effects, patients can use a non-comedogenic moisturiser, temporarily reduce the frequency of application of Duac Once Daily 10 mg/g + 30 mg/g Gel or temporarily discontinue use however; efficacy has not been established for less than once daily dosing frequencies.
Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy may occur, which sometimes may be severe, especially with the use of peeling, desquamating, or abrasive agents.
If severe local irritancy (e.g. severe erythema, severe dryness and itching, severe stinging/burning) occurs, Duac Once Daily 10 mg/g + 30 mg/g Gel should be discontinued.
As benzoyl peroxide may cause increased sensitivity to sunlight, sunlamps should not be used and deliberate or prolonged exposure to sun should be avoided or minimised. When exposure to strong sunlight cannot be avoided, patients should be advised to use a sunscreen product and wear protective clothing.
If a patient has sunburn, this should be resolved before using Duac Once Daily 10 mg/g + 30 mg/g Gel.
If prolonged or significant diarrhoea occurs or the patient suffers from abdominal cramps, treatment with Duac Once Daily 10 mg/g + 30 mg/g Gel should be discontinued immediately, as the symptoms may indicate antibiotic-associated colitis. Suitable diagnostic methods, such as the determination of Clostridium difficile and toxin and, if necessary, colonoscopy should be employed and treatment options for colitis considered.
The product may bleach hair or coloured fabrics. Avoid contact with hair, fabrics, furniture or carpeting.
Resistance to clindamycin
Patients with a recent history of systemic or topical clindamycin or erythromycin use are more likely to have pre-existing anti-microbial resistant Propionibacterium acnes and commensal flora (see section 5.1).
Cross-resistance
Cross-resistance may occur with other antibiotics such as lincomycin and erythromycin when using antibiotic monotherapy (see section 4.5).
4.5. Interaction with other medicinal products and other forms of interaction
No formal drug-drug interaction studies have been performed with Duac Once Daily 10 mg/g + 30 mg/g Gel.
Concomitant topical antibiotics, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol and/or astringents, should be used with caution as a cumulative irritant effect may occur.
Duac Once Daily 10 mg/g + 30 mg/g Gel should not be used in combination with erythromycin-containing products due to possible antagonism to the clindamycin component.
Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, caution should be exercised with concomitant use.
Concomitant application of Duac Once Daily 10 mg/g + 30 mg/g Gel with tretinoin, isotretinoin and tazarotene should be avoided since benzoyl peroxide may reduce their efficacy and increase irritation. If combination treatment is required, the products should be applied at different times of the day (e.g. one in the morning and the other in the evening).
Using topical benzoyl peroxide-containing preparations at the same time as topical sulfonamide-containing products may cause skin and facial hair to temporarily change colour (yellow/orange).
4.6. Fertility, pregnancy and lactation
Pregnancy
There are no adequate data from the use of Duac Once Daily 10 mg/g + 30 mg/g Gel in pregnant women. Animal reproductive/developmental studies have not been conducted with Duac Once Daily 10 mg/g + 30 mg/g Gel or benzoyl peroxide. There are limited data on the use of clindamycin and benzoyl peroxide alone in pregnant women. Data from a limited number of pregnancies exposed in the first trimester to clindamycin indicate no adverse effects of clindamycin on pregnancy or on the health of the fetus/new-born child.
Reproduction studies in rats and mice, using subcutaneous and oral doses of clindamycin, revealed no evidence of impaired fertility or harm to the fetus due to clindamycin.
The safety of Duac Once Daily 10 mg/g + 30 mg/g Gel in human pregnancy is not established. Therefore, Duac Once Daily 10 mg/g + 30 mg/g Gel should only be prescribed to pregnant women after careful risk/benefit assessment by the physician in charge.
Breastfeeding
Use of Duac Once Daily 10 mg/g + 30 mg/g Gel has not been studied during breastfeeding. Percutaneous absorption of clindamycin and benzoyl peroxide is low however; it is not known whether clindamycin or benzoyl peroxide is excreted in human milk following the use of Duac Once Daily 10 mg/g + 30 mg/g Gel. Oral and parenteral administration of clindamycin has been reported to result in the appearance of clindamycin in breast milk. For this reason, Duac Once Daily 10 mg/g + 30 mg/g Gel should be used during lactation only if the expected benefit justifies the potential risk to the infant.
To avoid accidental ingestion by the infant if used during lactation, Duac Once Daily 10 mg/g + 30 mg/g Gel should not be applied to the breast area.
Fertility
There are no data on the effect of Duac Once Daily 10 mg/g + 30 mg/g Gel on fertility in humans.
4.7. Effects on ability to drive and use machines
Not relevant
4.8. Undesirable effects
Adverse drug reactions (ADRs) are summarised below for Duac Once Daily 10 mg/g + 30 mg/g Gel as a combination, including any additional ADRs that have been reported for the single topical active ingredients, benzoyl peroxide or clindamycin, that occurred either during clinical studies or that were spontaneously reported. Adverse drug reactions are listed by MedDRA system organ class and by frequency. Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1000 to <1/100) and not known (cannot be estimated from the available data).
MedDRA SOC
Very Common
Common
Uncommon3
Not known2
Immune system disorders
Allergic reactions including hypersensitivity and anaphylaxis
Nervous system disorders
Headache4
Paraesthesia1
Gastrointestinal disorders
Colitis (including pseudomembranous colitis), haemorrhagic diarrhoea, diarrhoea, abdominal pain
Skin and subcutaneous tissue disorders1
Pruritus, burning sensation, dryness, erythema, peeling (Generally reported as 'slight' in severity. Frequency relates to data from solicited tolerability assessments during the clinical trial)
Dermatitis, photosensitivity reaction
Erythematous rash, worsening of acne
Urticaria
General disorders and Administration site conditions
Application site pain4
Application site reactions including skin discolouration
1At site of application. 2Based on post-marketing reports with topical clindamycin 10 mg/g + benzoyl peroxide 50 mg/g gel. Since these reports are from a population of uncertain size and are subject to confounding factors, it is not possible to reliably estimate their frequency however, systemic reactions are rarely seen. 3Reported from studies conducted with topical clindamycin 10 mg/g + benzoyl peroxide 50 mg/g gel. 4Reported from studies conducted with topical clindamycin 10 mg/g foam.
Local Tolerability
During the pivotal clinical trial with Duac Once Daily 10 mg/g + 30 mg/g Gel, patients were assessed for local cutaneous signs and symptoms of erythema, dryness, peeling, itching, and burning/stinging. The percentage of patients that had symptoms present before treatment, during treatment, and present at week 12 are shown in the next two tables:
Percentage of Subjects in the Duac Once Daily 10 mg/g + 30 mg/g Gel Group (N=327) with Symptoms of Burning/Stinging and Itching (patient assessed)
Before Treatment (Baseline)
Maximum During Treatment
End of Treatment (Week 12)
Slight
Mod
Strong
Slight
Mod
Strong
Slight
Mod
Strong
Burning/ Stinging
15%
4%
0
20%
6%
1%
8%
2%
<1%
Itching
28%
6%
1%
29%
9%
1%
17%
2%
0
Percentage of Subjects in the Duac Once Daily 10 mg/g + 30 mg/g Gel Group (N=327) with Signs of Dryness, Erythema and Peeling (investigator assessed)
Before Treatment (Baseline)
Maximum During Treatment
End of Treatment (Week 12)
Slight
Mild
Mod
Severe
Slight
Mild
Mod
Severe
Slight
Mild
Mod
Severe
Dryness
15%
2%
1%
0
24%
7%
2%
0
9%
1%
1%
0
Erythema
19%
11%
5%
0
26%
13%
5%
<1%
19%
4%
2%
0
Peeling
10%
2%
0
0
17%
3%
1%
0
4%
<1%
0
0
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
4.9. Overdose
Excessive application of Duac Once Daily 10 mg/g + 30 mg/g Gel may result in severe irritation. In this event, discontinue use and wait until the skin has recovered.
Topically applied benzoyl peroxide is not generally absorbed in sufficient amounts to produce systemic effects.
Excessive application of topically applied clindamycin may result in absorption of sufficient amounts to produce systemic effects.
In the event of accidental ingestion of Duac Once Daily 10 mg/g + 30 mg/g Gel, gastrointestinal adverse reactions similar to those seen with systemically administered clindamycin may be seen.
Appropriate symptomatic measures should be taken to provide relief from irritation due to excessive application.
Accidental ingestion should be managed clinically or as recommended by the National Poisons Centre, where available.
💬 Ask about this leaflet
Ask anything about Duac Once Daily 10 mg/g + 30 mg/g Gel. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.