Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Cyclizine 50mg Tablets
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Cyclizine hydrochloride may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
What it is and what it is used for
FOR Cyclizine Hydrochloride Tablets contain the active substance cyclizine hydrochloride, which belongs to a group of medicines called antihistamines which can be used to help stop you feeling sick (nausea) or being sick (vomiting). Cyclizine Hydrochloride Tablets may be used by adults and children aged 6 years and over. Cyclizine Hydrochloride Tablets may be used if you suffer from travel or motion sickness; nausea caused by cancer treatment (radiography) or other medicines; or if you have had an operation, as general anaesthetics can sometimes cause sickness. Cyclizine Hydrochloride Tablets can also be used to treat sickness caused by some inner ear problems such as Meniere's disease.
What you need to know before you take it
E CYCLIZINE HYDROCHLORIDE TABLETS Do not take Cyclizine Hydrochloride Tablets:
- if you are allergic to cyclizine hydrochloride or any of the other ingredients of this medicine (allergic reactions include mild symptoms such as itching and / or rash. More severe symptoms include swelling of the face, lips, tongue and / or throat with difficulty in swallowing or breathing)
- if you have been drinking alcohol. The anti-vomiting properties of cyclizine may increase the toxicity of alcohol.
Warnings and precautions Talk to your doctor, pharmacist or nurse before taking Cyclizine Hydrochloride Tablets if you:
- suffer from an eye disease caused by a rise of pressure within the eye (glaucoma)
- suffer from urinary retention (experience difficulty passing urine)
- have an obstructive bowel condition
- have any liver problems
- suffer from phaeochromocytoma (tumour of the medulla of the adrenal glands)
- suffer from high blood pressure
- have epilepsy
- are a man and you suffer from an enlarged prostate gland (difficulty or slowness passing urine)
- have been told your heart is not working properly (heart failure)
- suffer from an inherited disorder which can lead to a sensitivity to sunlight (porphyria). Other medicines and Cyclizine Hydrochloride Tablets Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines especially the following:
- medicines for problems such as depression, anxiety or difficulty in sleeping
- strong painkillers such as pethidine
- any medicine which belong to a group of medicines called anticholinergics. Cyclizine Hydrochloride Tablets with food and drink Alcohol should be avoided when you are taking Cyclizine Hydrochloride Tablets. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Driving and using machines You can drive while taking Cyclizine Hydrochloride Tablets but do not drive until you know how the tablets affect you. Cyclizine Hydrochloride Tablets may make you feel dizzy. If they affect you in this way, do not drive or operate any machinery. Cyclizine Hydrochloride Tablets contain lactose. If you have been told that you have intolerance to some sugars, talk to your doctor before taking these tablets.
How to take it
CYCLIZINE HYDROCHLORIDE TABLETS Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor, pharmacist or nurse if you are not sure. Adults The recommended dose is one tablet up to three times daily. Use in children and adolescents
Children over 12 years The recommended dose is one tablet up to three times daily. Children from 6 to 12 years The recommended dose is half a tablet up to three times a day. The tablet can be divided into equal doses along the line scored on one side of the tablet. Children under 6 years Do not give this medicine to children under the age of 6. The tablets should be swallowed with a little water. If you take more Cyclizine Hydrochloride Tablets than you should Symptoms of overdose include dry mouth, nose and throat, blurred vision, fast or irregular heartbeat, difficulty passing urine, drowsiness, dizziness, lack of balance and coordination, weakness, excitability, disorientation, impaired judgement, hallucinations, muscle spasm, involuntary movements, convulsions, high temperature and difficulty breathing. If you take more Cyclizine Hydrochloride Tablets than you should, contact your doctor or nearest hospital emergency department immediately. Remember to take this leaflet and/or the package with you to show the doctor what you have taken. If you forget to take Cyclizine Hydrochloride Tablets If you forget to take a dose, just take the next dose at the usual time, DO NOT take a double dose to make up for a forgotten tablet.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. If you notice:
- itching or skin rashes
- swelling of the face, lips or throat
- difficulty in breathing or wheeziness stop taking this medicine and tell your doctor immediately. These may be signs of an allergic reaction. The following side effects are reported with a not known frequency (frequency cannot be estimated from the available data):
- skin rashes or itching
- drowsiness
- lack of coordination
- headache
- a dry mouth, nose or throat
- blurred vision
- involuntary rolling of the eyes
- fast heartbeat
- irregular heartbeat
- difficulty in passing water
- constipation
- heartburn (reflux)
- feeling sick
- being sick
- diarrhoea
- stomach pain
- loss of appetite
- restlessness
- nervousness
- euphoria
- difficulty in sleeping
- ringing in the ears
- seeing or hearing things that are not really there (hallucinations)
- decrease in muscle tone
- unusual body movements, particularly of your hands, arms or legs
- muscle twitches, spasms or tremors
- seizures
- being confused, disorientated or unaware
- dizziness
- feeling weak
- decreased consciousness
- temporary difficulty in speaking
- high blood pressure
- low blood pressure
- pins and needles
- yellowing of the skin and the whites of your eyes (jaundice)
- a red or brownish patch which appears at the same spot each time you take the medicine
- an increased sensitivity to sunlight (photosensitivity)
- inflammation of the liver (hepatitis) or problems with the liver
- reduced rate of breathing (apnoea)
- reduction in the production of a type of white blood cell making infection more likely (agranulocytosis).
- unpleasant sensation or an overwhelming urge to move the legs (also called Restless Legs Syndrome). If you feel very tired, experience unexpected bruising or bleeding or more infections (e.g. colds and sore throats) than usual please tell your doctor. Your doctor may decide to conduct tests on your blood periodically as a result of these symptoms. If any of the side effects becomes severe or you notice any side effects not listed in this leaflet please tell your doctor or pharmacist immediately.
Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme, website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.
How to store it
CYCLIZINE HYDROCHLORIDE TABLETS Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and label after EXP. The expiry date refers to the last day of that month. Store this medicine in a safe place below 25°C. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Contents of the pack and other information
What Cyclizine Hydrochloride Tablets contains Each tablet contains 50 mg of the active ingredient, cyclizine hydrochloride. The other ingredients include: lactose, potato starch, acacia and magnesium stearate. What Cyclizine Hydrochloride Tablets look like and contents of the pack Cyclizine Hydrochloride Tablets are white with a single score line and the marking "T4A" on the same side. They are available in bottles of 100 tablets. Marketing Authorisation Holder Amdipharm UK Limited, Dashwood House, 69 Old Broad Street, London, EC2M 1QS, United Kingdom
Manufacturer: CENEXI SAS, 52 Rue Marcel et Jacques Gaucher, 94120, Fontenay sous Bois, France This leaflet was last revised in January 2024.
Frequently asked questions about Cyclizine 50mg Tablets
How do I take Cyclizine 50mg Tablets?
Cyclizine 50mg Tablets comes as tablet containing 50mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Cyclizine 50mg Tablets?
The active substance in Cyclizine 50mg Tablets is cyclizine hydrochloride.
Are there equivalent medicines to Cyclizine 50mg Tablets?
Medicines with the same active substance, strength and form include: Valoid 50 mg Tablets, Cyclizine Hydrochloride 50mg Tablets, Cyclizine hydrochloride 50 mg Tablets. They are interchangeable only if your prescriber or pharmacist says so.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Cyclizine 50mg Tablets, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Cyclizine 50mg Tablets without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: cyclizine hydrochloride
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
Cyclizine Hydrochloride is indicated in adults and in children aged 6 years and over for the prevention and treatment of nausea and vomiting including:-
• Motion sickness.
• Nausea and vomiting caused by narcotic analgesics and by general anaesthetics in the post-operative period.
• Vomiting associated with radiotherapy, especially for breast cancer since cyclizine does not elevate prolactin levels.
Cyclizine Hydrochloride may be of value in relieving vomiting and attacks of vertigo associated with Menière's disease and other forms of vestibular disturbance.
4.2. Posology and method of administration
Posology
To prevent motion sickness Cyclizine Hydrochloride should be taken about one to two hours before departure.
Elderly
There have been no specific studies of Cyclizine Hydrochloride in the elderly. Experience has indicated that normal adult dosage is appropriate.
Paediatric population
Children less than 6 years of age:
Cyclizine Hydrochloride tablets are not recommended for children less than 6 years of age.
Children 6 to 12 years of age:
25 mg orally, which may be repeated up to three times a day.
Children over 12 years of age:
50 mg orally, which may be repeated up to three times a day.
Adults
50 mg orally, which may be repeated up to three times a day.
Method of administration:
Oral
4.3. Contraindications
Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Cyclizine is contraindicated in the presence of acute alcohol intoxication. The anti-emetic properties of cyclizine may increase the toxicity of alcohol.
4.4. Special warnings and precautions for use
As with other anticholinergic agents, Cyclizine Hydrochloride may precipitate incipient glaucoma and it should be used with caution and appropriate monitoring in patients with glaucoma, urinary retention, obstructive disease of the gastrointestinal tract, hepatic disease, phaeochromocytoma, hypertension, epilepsy and in males with possible prostatic hypertrophy.
Cyclizine should be used with caution in patients with severe heart failure or acute myocardial infarction. In such patients, cyclizine may cause a fall in cardiac output associated with increases in heart rate, mean arterial pressure and pulmonary wedge pressure.
Cyclizine should be avoided in porphyria.
There have been reports of abuse of cyclizine, either oral or intravenous, for its euphoric or hallucinatory effects. The concomitant misuse of Cyclizine Hydrochloride with large amounts of alcohol is particularly dangerous, since the antiemetic effect of cyclizine may increase the toxicity of alcohol (see also sections 4.3 and 4.5).
Cyclizine Hydrochloride contains lactose
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
4.5. Interaction with other medicinal products and other forms of interaction
Cyclizine Hydrochloride may have additive effects with alcohol and other central nervous system depressants e.g. hypnotics, tranquillisers, anaesthetics antipsychotics, barbiturates.
Cyclizine Hydrochloride enhances the soporific effect of pethidine.
Cyclizine Hydrochloride may counteract the haemodynamic benefits of opioid analgesics.
Because of its anticholinergic activity cyclizine may enhance the side-effects of other anticholinergic drugs, and have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs).
Cyclizine Hydrochloride may mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibacterials.
4.6. Fertility, pregnancy and lactation
Pregnancy:
In the absence of any definitive human data, the use of Cyclizine Hydrochloride in pregnancy is not advised.
Breast-feeding:
Cyclizine is excreted in human milk; however, the amount has not been quantified
Fertility:
In a study involving prolonged administration of cyclizine to male and female rats, there was no evidence of impaired fertility after continuous treatment for 90-100 days at dose levels of approximately 15 and 25 mg/kg/day. There is no experience of the effect of Cyclizine Hydrochloride on human fertility.
4.7. Effects on ability to drive and use machines
Studies designed to detect drowsiness did not reveal sedation in healthy adults who took a single oral therapeutic dose (50 mg) of cyclizine.
Patients should not drive or operate machinery until they have determined their own response.
Although there are no data available, patients should be cautioned that Cyclizine Hydrochloride may have additive effects with alcohol and other central nervous system depressants, e.g. hypnotics and tranquillisers.
4.8. Undesirable effects
Adverse reactions are ranked under heading of frequency, the most frequent first, using the following convention: Very common: (≥1/10); Common (≥1/100 to <1/10); Uncommon (≥1/1,000 to <1/100); Rare (≥1/10,000 to <1/1,000); Very rare (<1/10,000); Not known: cannot be estimated from the available data.
System Organ Class
Frequency
Adverse reactions
Blood and lymphatic system disorders
Not known
Agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia
Cardiac disorders
Not known
Tachycardia, palpitations, arrhythmias
Ear and labyrinth disorder
Not known
Tinnitus
Eye disorders
Not known
Blurred vision, oculogyric crisis
Gastrointestinal disorders
Not known
Dryness of the mouth, nose and throat, constipation increased gastric reflux.
Nausea, vomiting, diarrhoea stomach pain
Loss of appetite
General disorders and administration site conditions
Not known
Asthenia
Hepatobiliary disorders
Not known
Hepatic dysfunction, hypersensitivity hepatitis, cholestatic jaundice and cholestatic hepatitis have occurred in association with cyclizine
Immune system disorders
Not known
Hypersensitivity reactions, including anaphylaxis have occurred
Musculoskeletal and connective tissue disorders
Not known
Twitching, muscle spasms
Nervous system disorders
Not known
Effects on the central nervous system have been reported with cyclizine these include somnolence, drowsiness, incoordination headache, dystonia, dyskinesia, extrapyramidal motor disturbances, restless leg syndrome, tremor, convulsions, dizziness, decreased consciousness, transient speech disorders, paraesthesia and generalised chorea
Psychiatric disorders
Not known
Disorientation, restlessness, nervousness, euphoria, insomnia and auditory and visual hallucinations have been reported, particularly when dosage recommendations have been exceeded
Renal and urinary disorders
Not known
Urinary retention
Respiratory, thoracic and mediastinal disorders
Not known
Bronchospasm, apnoea
Skin and subcutaneous tissue disorders
Not known
Urticaria, drug rash, angioedema, allergic skin reactions, fixed drug eruption photosensitivity
Vascular disorders
Not known
Hypertension, hypotension
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme, website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
4.9. Overdose
Symptoms:
Symptoms of acute toxicity from cyclizine arise from peripheral anticholinergic effects and effects on the central nervous system.
Peripheral anticholinergic symptoms include dry mouth, nose and throat, blurred vision, tachycardia and urinary retention. Central nervous system effects include drowsiness, dizziness, incoordination, ataxia, weakness, hyperexcitability, disorientation, impaired judgement, hallucinations, hyperkinesia, extrapyramidal motor disturbances, convulsions, hyperpyrexia and respiratory depression.
An oral dose of 5 mg/kg is likely to be associated with at least one of the clinical symptoms stated above. Younger children are more susceptible to convulsions. The incidence of convulsions, in children less than 5 years, is about 60% when the oral dose ingested exceeds 40 mg/kg.
Management:
In the management of acute overdosage with Cyclizine Hydrochloride, gastric lavage and supportive measures for respiration and circulation should be performed if necessary. Convulsions should be controlled in the usual way with parenteral anticonvulsant therapy.
💬 Ask about this leaflet
Ask anything about Cyclizine 50mg Tablets. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.