Pharmacy Guide

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Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.

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Clobetasol propionate 500 micrograms/g shampoo

⚠ This medicine appears to have been discontinued

The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.

If you were prescribed this medicine, other products containing Clobetasol propionate may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.

Active substance: Clobetasol propionate

Source: electronic medicines compendium (emc)
Official leaflet: Read the PIL on emc

What it is and what it is used for

for

Clobetasol propionate shampoo contains the active substance called clobetasol propionate; it belongs to a group of medicines called topical corticosteroids (or steroids). Topical corticosteroids are further classified into groups depending on their strength; clobetasol propionate is a very strong corticosteroid. « Topical » means that it should only be applied to the surface of the skin. Topical steroids reduce the redness, itchiness and inflammation associated with skin conditions. Scalp psoriasis is caused by the skin cells of your scalp being produced too quickly. clobetasol propionate shampoo is used to treat scalp psoriasis of moderate intensity in adults. Corticosteroid creams, ointments and other topical preparations come in four different potencies or strengths. These are known as mild, moderately potent, potent or very potent. Healthcare professionals will usually refer to topical corticosteroid potency rather than strength. A potent or strong corticosteroid has a much stronger effect than a mild corticosteroid when using the same amount. The percentage of active ingredient that is sometimes included on product packaging does not indicate potency. Clobetasol propionate is classed as a very strong corticosteroid. Your healthcare professional will prescribe or advise a steroid of the appropriate potency for your condition. 2.

What you need to know before you take it

e clobetasol propionate 500 micrograms/g shampoo

Do not use clobetasol propionate 500 micrograms/g shampoo

  • if you are allergic to clobetasol propionate or any of the other ingredients of this medicine (listed in section 6).
  • If you have bacterial, viral, fungal or parasitic skin infections such as cold sores, varicella (chicken pox), herpes zoster (shingles), impetigo (type of rash on the face), ringworm, athletes foot, thrush, skin tuberculosis or skin disease caused by syphilis.
  • If you have ulcerous wounds (weeping wounds) on your scalp.
  • In children under two years old. 2

•

Do not apply clobetasol propionate shampoo in the eyes or on eyelids (risk of glaucoma which is high pressure in the eye and risk of cataract which is a clouding of the lens in the eye).

Warnings and precautions Talk to your doctor or pharmacist before using clobetasol propionate 500 micrograms/g shampoo:

  • If you experience newly developed bone pain or worsening of previous bone symptoms during a treatment with clobetasol propionate shampoo, especially if you have been using clobetasol propionate shampoo for a prolonged time or repeatedly.
  • If you use other oral/topical medication containing corticosteroids or medications intended to control your immune system (e.g. for autoimmune disease or after a transplantation). Combining clobetasol propionate shampoo with these medicines may result in serious infections.
  • When using clobetasol propionate shampoo, it must only be used on the scalp, do not use it as a regular shampoo or on other areas of the body and do not use clobetasol propionate shampoo as a shower gel, body wash or bath foam.
  • When treating the scalp with clobetasol propionate shampoo you must not cover the area being treated, for example: a shower cap must not be used as it may make the active substance pass through the skin and affect the other parts of the body.
  • When using clobetasol propionate shampoo, avoid contact with the face, eyelids, axillae (armpits), erosive skin (chapped skin) surface and genital regions. Rinse off immediately with water if any product runs from the scalp.
  • If you get clobetasol propionate shampoo in your eye(s), wash the affected eye thoroughly with water. If any irritation persists, please seek advice from your doctor.
  • If you do not notice an improvement of your scalp psoriasis, please see your doctor.
  • If there is a worsening of your condition during use consult your prescriber – you may be experiencing an allergic reaction, have an infection or your condition requires a different treatment.
  • If you experience a recurrence of your condition shortly after stopping treatment, within 2 weeks, do not restart using the cream/ointment/shampoo without consulting your prescriber unless your prescriber has previously advised you to so. If your condition has resolved and on recurrence the redness extends beyond the initial treatment area and you experience a burning sensation, please seek medical advice before restarting treatment.
  • Contact your doctor if you experience blurred vision or other visual disturbances. Children and adolescents
  • If this product has been prescribed for a child or adolescent below 18 years of age, you must check with your doctor every week before continuing to use this product Other medicines and clobetasol propionate 500 micrograms/g shampoo Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Pregnancy, breast-feeding and fertility If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Driving and using machines Clobetasol propionate shampoo has no or very little influence on the ability to drive and use machines. 3.

How to take it

clobetasol propionate 500 micrograms/g shampoo

Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. The usual daily dose per application is an amount equivalent to around a half tablespoon (around 7.5 ml) sufficient to cover the entire scalp.

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Unless your doctor has instructed otherwise, wash your hands and apply clobetasol propionate shampoo directly to your dry scalp once daily taking care to well cover and massage the affected areas. Avoid using large amounts of clobetasol propionate shampoo, only use enough to cover your scalp when dry. Wash your hands carefully after application. Leave the product to work for 15 minutes without covering, and then add water, rinse and dry your hair as usual. Your regular shampoo can be used if more shampoo is required to wash your hair. Do not add more of clobetasol propionate shampoo to your hair. Your doctor will tell you how long you need to use clobetasol propionate shampoo to control your scalp psoriasis. Treatment should not normally continue for more than 4 weeks. However, if your scalp psoriasis is significantly improved before the end of treatment, please see your doctor. On the contrary, if no improvement is seen by the end of the treatment, please tell your doctor. This treatment needs careful supervision; you should let your doctor review your progress at regular intervals. Do not use clobetasol propionate shampoo for longer than your doctor tells you. Nonetheless, your doctor may ask you to use clobetasol propionate shampoo again in the future following a period of no use. Use in children and adolescents If this product has been prescribed for children or adolescents between the ages of 2 and 18 years, the instructions given by your doctor must be followed. You must check with the doctor every week before continuing treatment. If you use more clobetasol propionate 500 micrograms/g shampoo than you should If you have used clobetasol propionate shampoo for much longer than you should, please see your doctor. This product is for use on the scalp only. Do not swallow it. If you accidentally do so, small amounts are not harmful. If you are not sure, seek immediate medical advice. If you forget to use clobetasol propionate 500 micrograms/g shampoo If you forget to use clobetasol propionate shampoo, do not take a double dose to make up for a forgotten dose. Go back to your regular schedule. If you miss several doses, tell your doctor. If you stop using clobetasol propionate 500 micrograms/g shampoo If you stop using clobetasol propionate shampoo, please see your doctor. It may be that worsening of the disease occurs when treatment with clobetasol propionate shampoo is stopped, especially if it has been used for a long time. Tell your doctor if you observe such a worsening of your scalp psoriasis conditions. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 4.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. clobetasol propionate shampoo may cause the following side effects: Common side effects (may affect up to 1 in 10 people):

  • Skin burning sensation
  • Inflammation of one or more hair follicles Uncommon side effects (may affect up to 1 in 100 people):
  • Endocrine disorders (such as adrenal suppression, Cushing syndrome), have been observed with potent topical steroids, especially when applied on large surface areas or used for prolonged periods
  • Eye stinging or burning
  • Eye irritation
  • Ocular tight sensation 4

• • • • • • • • • • • • • • • • • • •

Glaucoma Hypersensitivity Headache Pain of skin Skin discomfort Itching Acne Skin oedema Telangiectasia (veins under the surface of your skin may becoming more noticeable) Psoriasis aggravation Hair loss Dryness of the skin Urticaria Skin atrophy (thinning of your skin) Skin irritation Skin tightness Allergic contact dermatitis Erythema Rash

Not known (frequency cannot be estimated from the available data)

  • Blurred vision. Irritation, itching, urticaria, visible small vessels or thinning skin around the treated areas are generally of a mild to moderate nature.
  • If you have any signs of local intolerance, such as a burning sensation or redness to the areas that have been treated, do not use clobetasol propionate shampoo until these symptoms have disappeared.
  • Stop using the medicine and tell your doctor as soon as possible if you find your condition gets worse during treatment (this is more likely to happen if you have been using clobetasol propionate shampoo longer than prescribed) or if you experience swelling of the eyelids, face or lips as you may be allergic to the product or have a skin infection.
  • Using large amounts or keeping the product on the scalp for more than 15 minutes may: o cause the skin to become thinner so that it can damage more easily, o allow the active substance to pass through the skin; this can affect other parts of the body, especially in children, and during pregnancy.
  • Repeated courses of topical steroids over a long time may also sometimes cause, pustular eruptions (big pimples) and changes in hair growth and skin colour. Striae (stretch marks) and purpura (bruising) may become noticeable.
  • If you have rosacea (facial erythema associated with flushing of the skin, and possible papulopustules) the application of clobetasol propionate shampoo on the face may cause your skin condition to worsen.
  • Application of clobetasol propionate shampoo on the face may induce perioral dermatitis (spotty red rash around the mouth).
  • Application of clobetasol propionate shampoo to the skin may cause thinning of skin and therefore it should never be used on the face or on other areas of the skin than the scalp.
  • In order to avoid interaction with hair colour dying product, such as hair colour changes, clobetasol propionate shampoo should be thoroughly rinsed.
  • If you have any unusual discomfort that you do not understand, tell your doctor as soon as possible.
  • Steroid withdrawal reaction: If used for prolonged periods a withdrawal reaction, which might appear to be different from the previous condition may occur in some patients during treatment or within days to weeks after stopping treatment with some or all of the following features: redness of the skin which can extend beyond the initial area treated, a burning or stinging sensation, intense itching, peeling of the skin, oozing open sores. Reporting of side effects 5

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine. 5.

How to store it

clobetasol propionate 500 micrograms/g shampoo

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the bottle and the carton. The expiry date refers to the last day of that month. Store in the original plastic bottle in order to protect from light. Discard the bottle 4 weeks after first opening. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment. 6.

Contents of the pack and other information

What clobetasol propionate 500 micrograms/g shampoo contains

  • The active substance is clobetasol propionate. Each gram of clobetasol propionate shampoo contains 500 micrograms of clobetasol propionate. 1 g of shampoo corresponds to 1 mL of shampoo. •

The other excipients are: Ethanol 96%, coco alkyl dimethyl betaine, sodium laureth sulfate, polyquaternium-10, sodium citrate, citric acid monohydrate, purified water.

What clobetasol propionate 500 micrograms/g shampoo looks like and contents of the pack This medicine is a colourless to slightly yellow viscous liquid shampoo clear to slightly cloudy in appearance. It is available on prescription from your doctor in HDPE (high density polyethylene) plastic bottles sealed by a polypropylene cap (125 ml bottles). Marketing Authorisation Holder Vygoris Limited 930 High Road London, N12 9RT United Kingdom Tel: +44 (0) 1223 395301 Manufacturer Farmaclair 440 Avenue du General de Gaulle 14200 Hérouville Saint Clair France Stradis 29 Rue Léon Faucher 51100 Reims France This leaflet was last revised in June 2026.

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Frequently asked questions about Clobetasol propionate 500 micrograms/g shampoo

What is the active substance in Clobetasol propionate 500 micrograms/g shampoo?

The active substance in Clobetasol propionate 500 micrograms/g shampoo is clobetasol propionate.

Are there equivalent medicines to Clobetasol propionate 500 micrograms/g shampoo?

Medicines with the same active substance, strength and form include: CLARELUX 500 microgram/g cutaneous foam in pressurised container, Etrivex 500 micrograms/g Shampoo, Clobetasol propionate 500 microgram/g Shampoo. They are interchangeable only if your prescriber or pharmacist says so.

Where does this information come from?

This leaflet reproduces the patient information leaflet approved for Clobetasol propionate 500 micrograms/g shampoo, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.

Can I get Clobetasol propionate 500 micrograms/g shampoo without a prescription?

Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.

About this leaflet

The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.

Medical disclaimer: This page is for information only and does not replace advice from your doctor or pharmacist. Always read the leaflet supplied with your medicine. If you are unwell, call NHS 111; in an emergency, call 999.

Medicines with the same active substance: Clobetasol propionate (9 medicines)
See every medicine containing this substance, or browse the full A–Z of active substances.
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
Technical information intended for healthcare professionals (doctors and pharmacists). The Summary of Product Characteristics (SmPC) is the official document approved by the MHRA/EMA. It does not replace the patient leaflet or a doctor’s advice.

4.1. Therapeutic indications

Topical treatment of moderate scalp psoriasis in adults.

4.2. Posology and method of administration

Clobetasol propionate belongs to the most potent class of topical corticosteroids (Group IV) and prolonged use may result in serious undesirable effects (see section 4.4). If treatment with a local corticosteroid is clinically justified beyond 4 weeks, a less potent corticosteroid preparation should be considered. Repeated but short courses of clobetasol propionate may be used to control exacerbations (see details below).

Posology

Clobetasol propionate 500 micrograms/g shampoo should be applied directly on dry scalp once daily taking care to well cover and massage the lesions. An amount equivalent to around a half tablespoon (around 7.5 ml) per application is sufficient to cover all the scalp.

The total dosage should not exceed 50 g per week.

Method of administration

For cutaneous use on the scalp only.

After application, clobetasol propionate 500 micrograms/g shampoo should be kept in place without covering for 15 minutes. Hands should be washed carefully after application. After 15 minutes, the product must be thoroughly rinsed with water and/ or hair can be washed by using an additional amount of regular shampoo if needed to facilitate washing. Then, hair can be dried as usual.

The treatment duration should be limited to a maximum of 4 weeks. As soon as clinical results are observed, applications should be spaced out or replaced, if needed, by an alternative treatment. If no improvement is seen within four weeks, reassessment of the diagnosis may be necessary.

Repeated courses of clobetasol propionate 500 micrograms/g shampoo may be used to control exacerbations provided the patient is under regular medical supervision.

Special population

Elderly

The safety and efficacy of clobetasol propionate 500 micrograms/g shampoo in geriatric patients aged 65 years and above have not been established.

Renal impairment

Clobetasol propionate 500 micrograms/g shampoo has not been studied in patients with renal impairment.

Hepatic impairment

Patients with severe liver dysfunction should be treated with special caution and closely monitored for side-effects.

Paediatric population

The experience in the paediatric population is limited. Clobetasol propionate 500 micrograms/g shampoo is not recommended for use in children and adolescents below 18 years of age. It is contraindicated in children under 2 years of age (see sections 4.3 and 4.4).

4.3. Contraindications

Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.

Clobetasol propionate 500 micrograms/g shampoo must not be applied on skin areas affected by bacterial, viral (varicella, herpes simplex, herpes zoster), fungal or parasitic infections, ulcerous wounds and specific skin diseases (skin tuberculosis, skin diseases caused by lues).

Clobetasol propionate 500 micrograms/g shampoo must not be applied to the eye and eyelids (risk of glaucoma, risk of cataract).

Children under 2 years of age.

4.4. Special warnings and precautions for use

Hypersensitivity to corticosteroids can be observed.

Therefore, clobetasol propionate, is not recommended in patients who are hypersensitive to other corticosteroids.

Long-term continuous therapy with corticosteroids, use of occlusive mobcaps, treatment of large surface areas especially in children can enhance absorption and lead to a higher risk of systemic effects. In such cases, medical supervision should be increased and patients may be evaluated periodically for evidence of HPA axis suppression. Systemic absorption of topical corticosteroids induced by prolonged use especially on large surface areas has caused reversible adrenal suppression with the potential for glucocorticosteroid insufficiency, manifestations of Cushing's syndrome in some patients. Such systemic effects resolve when treatment is stopped. However, abrupt discontinuation can lead to acute adrenal insufficiency, especially in children.

Cases of osteonecrosis serious infections (including necrotizing fasciitis) and systemic immunosuppression (sometimes resulting in reversible Kaposi's sarcoma lesions) have been reported with long-term use of clobetasol propionate beyond the recommended doses (see section 4.2). In some cases patients used concomitantly other potent oral/topical corticosteroids or immunosuppressors (e.g. methotrexate, mycophenolate mofetil). If treatment with local corticosteroids is clinically justified beyond 4 weeks, a less potent corticosteroid preparation should be considered.

Patient with severe diabetes mellitus should be treated with special caution and closely monitored for side-effects.

Topical corticosteroids should be used with caution as development of tolerance (tachyphylaxis) may occur as well as local toxicity such as skin atrophy, infection and telangiectasia of the skin.

Clobetasol propionate 500 micrograms/g shampoo is only intended for the treatment of scalp psoriasis and should not be used to treat other skin areas. In particular, Clobetasol propionate 500 micrograms/g shampoo is not recommended for use in the face, intertriginous areas (axillae and genitoanal regions) and on other erosive skin surfaces as this could increase the risk of adverse events such as atrophic changes, telangiectasia, corticosteroid-induced dermatitis or secondary infection. The face, more than other areas of the body, may exhibit atrophic changes after prolonged treatment with potent topical corticosteroids.

In rare instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked generalised pustular psoriasis in case of intensive and prolonged topical use.

Clobetasol propionate, is not recommended in patients with acne vulgaris, rosacea or perioral dermatitis.

There may be a risk of post-treatment rebound or relapse upon abrupt discontinuation of treatment with clobetasol propionate. Medical supervision should therefore continue in the post-treatment period.

Topical steroid withdrawal syndrome

Long term use of topical steroids can result in the development of rebound flares after stopping treatment (topical steroid withdrawal syndrome). A severe form of rebound flare can develop which takes the form of a dermatitis with intense redness, stinging and burning that can spread beyond the initial treatment area. It is more likely to occur when delicate skin sites such as the face and flexures are treated. Should there be a reoccurrence of the condition within days to weeks after successful treatment a withdrawal reaction should be suspected. Reapplication should be with caution and specialist advise is recommended in these cases or other treatment options should be considered.

If clobetasol propionate 500 micrograms/g shampoo does enter the eye, the affected eye should be rinsed with copious amounts of water.

Patients should be instructed to use clobetasol propionate 500 micrograms/g shampoo for the minimum amount of time necessary to achieve the desired results. If signs of local intolerance appear, application should be suspended until they disappear. If signs of hypersensitivity appear, application should be stopped immediately.

In order to avoid interaction with hair colour dying product, such as hair colour changes, clobetasol propionate shampoo should be thoroughly rinsed.

Visual disturbance

Visual disturbance may be reported with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR) which have been reported after use of systemic and topical corticosteroids.

Paediatric population

In this age group, growth retardation may also be observed in case of systemic absorption of topical corticosteroids. clobetasol propionate 500 micrograms/g shampoo should not be used in children and adolescents between 2 and 18 years of age.

If clobetasol propionate 500 micrograms/g shampoo is used in children and adolescents below 18 years of age, the treatment should be reviewed weekly.

The label will state very strong steroid.

4.5. Interaction with other medicinal products and other forms of interaction

No interaction studies have been performed.

4.6. Fertility, pregnancy and lactation

Pregnancy

There are no adequate data from the use of topical clobetasol propionate in pregnant women. Studies in animals have shown reproductive toxicity (see section 5.3). The potential risk for humans is unknown.

Clobetasol propionate 500 micrograms/g shampoo should not be used during pregnancy unless clearly necessary.

Breast-feeding

Systemically administered corticosteroids pass into breast milk. Damage to the infant is not reported to date. Nevertheless, as there are no adequate data on the possible milk transfer of topical clobetasol propionate and its biological or clinical repercussions, clobetasol propionate 500 micrograms/g shampoo should not be prescribed to breastfeeding women unless clearly indicated.

Fertility

No clinical data is available. See section 5.3.

4.7. Effects on ability to drive and use machines

Clobetasol propionate 500 micrograms/g shampoo has no or negligible influence on the ability to drive and use machines.

4.8. Undesirable effects

Summary of the safety profile

During clinical development of clobetasol propionate 500 micrograms/g shampoo, in a total of 558 patients receiving clobetasol propionate 500 micrograms/g shampoo, the most commonly reported adverse drug reaction was skin burning sensation. Its incidence was about 2.8%. Most adverse events were rated as mild to moderate and they were not affected by race or gender. Clinical signs of skin irritation were uncommon (0.2%). No serious drug-related adverse events were reported during any of the clinical trials.

Tabulated list of adverse reactions

The adverse reactions are classified by System Organ Class and frequency, using the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to <1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data) and were reported with clobetasol propionate 500 micrograms/g shampoo in clinical studies and post-marketing (see Table 1).

Table 1 – Adverse reactions

System Organ Class

Frequency

Adverse reactions

Endocrine disorders

Uncommon

Adrenal suppression

Cushing syndrome

Eye disorders

Uncommon

Eye stinging/burning

Eye irritation

Ocular tight sensation

Uncommon

Glaucoma

Not known

Vision, blurred (see also section 4.4)

Immune System Disorders

Uncommon

Hypersensitivity

Nervous System disorders

Uncommon

Headache

Skin and subcutaneous tissue disorders

Common

Skin burning sensation, Folliculitis

Uncommon

Pain of skin

Skin discomfort

Pruritus

Acne

Skin oedema

Telangiectasia

Psoriasis (aggravation)

Alopecia

Dry skin

Urticaria

Skin atrophy

Skin irritation

Skin tightness

Allergic contact dermatitis, erythema, rash

Not known

Withdrawal reactions - redness of the skin which may extend to areas beyond the initial affected area, burning or stinging sensation, itch, skin peeling, oozing pustules. (see section 4.4)

As clobetasol propionate 500 micrograms/g shampoo is to be kept in place for only 15 minutes before rinsing, systemic absorption is seldom observed (see section 5.2) and therefore, the risk of appearance of HPA axis suppression is very low compared to non rinsed potent corticosteroids products. Should HPA axis suppression occur, it is likely to be transient with a rapid return to normal values.

Cataract has been reported when corticosteroids where applied to the eyes or eyelids.

Immunosuppression and opportunistic infections have been reported in case of prolonged use of potent topical corticosteroids in rare instances.

Growth retardation may be observed in children in case of systemic absorption of topical corticosteroids.

Although not observed with clobetasol propionate 500 micrograms/g shampoo, prolonged and/or intensive treatment with potent corticosteroid preparations may cause striae, purpura, and generalised pustular psoriasis.

Rebound effects may occur upon discontinuation of treatment.

When applied to the face, very potent corticosteroids can also induce perioral dermatitis or worsen rosacea.

There are reports of pigmentation changes, pustular eruptions and hypertrichosis with topical corticosteroids.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

4.9. Overdose

Acute overdose is very unlikely to occur, however, in the case of chronic overdose or misuse, the features of hypercortisolism may appear and in this situation, treatment should be discontinued gradually. However, because of the risk of acute adrenal suppression, this should be done under medical supervision.

💬 Ask about this leaflet

Ask anything about Clobetasol propionate 500 micrograms/g shampoo. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.

Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.

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