Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Pharmacy Guide
Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.
Canesten Thrush Internal Cream 10% w/w vaginal cream
⚠ This medicine appears to have been discontinued
The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.
If you were prescribed this medicine, other products containing Clotrimazole may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.
How to take it
CANESTEN® THRUSH INTERNAL CREAM
If Canesten Thrush Internal Cream has been prescribed for you by your doctor, follow any instructions he/she may have given you. If you purchased this product without a prescription, follow these directions closely: The cream should be inserted as high as possible into the vagina, preferably before going to sleep at night for convenient and comfortable treatment. Wash your hands before removing the foil from the blister pack and again afterwards when you have used the applicator. 1. Remove the applicator from the packaging. Keeping the cap in place, insert the tip of plunger A into the applicator B (approximately 1cm).
2. Twist and pull to remove the cap C. Be careful not to press the plunger in any further before you have inserted the applicator into the vagina. This will avoid wasting any cream.
3. Carefully put the applicator as deep as is comfortable into the vagina (this is easiest when lying on your back with your knees bent up). Holding the applicator in place, slowly press the plunger until it stops so that the pre-measured dose of cream is deposited into the vagina.
6.FURTHER INFORMATION
What Canesten® Thrush Internal Cream contains:
- The active substance is clotrimazole at a strength of 500mg (10% w/w).
- The other ingredients are benzyl alcohol, polysorbate 60, sorbitan stearate, cetostearyl alcohol, isopropyl myristate, cetyl palmitate and water. See Section 2 'Do not use' and 'Important information about some of the ingredients' for cetostearyl alcohol and benzyl alcohol advice.
What Canesten® Thrush Internal Cream looks like and contents of the pack: 4. Remove the applicator. Dispose of the applicator in a safe place, out of the reach of children. The applicator cannot be flushed down the toilet. The cream is deposited in the vagina, but it is quite common to notice a slight discharge after using the cream and therefore it may be helpful to wear a panty liner. This does not mean that the treatment has not worked. The symptoms of thrush should disappear within three days of treatment. If no improvement is seen after seven days you must tell your doctor. If the infection returns after seven days you may use one further treatment, but if you have more than two infections within six months you should see your doctor.
Canesten Thrush Internal Cream is available in single-dose packs containing 5g of white cream in a pre-filled applicator. Marketing Authorisation Holder: Bayer plc, 400 South Oak Way, Reading, RG2 6AD, UK. Manufacturer: Kern Pharma S.L. Poligon Industrial Colon II, Calle Venus 72 08228 Terrassa, Barcelona, Spain. Remember: If you have any doubts about using Canesten® Thrush Internal Cream correctly, seek the advice of your doctor or pharmacist.
Canesten® Internal Cream is for use in the vagina only:
Further information about vaginal thrush: Vaginal thrush (candidiasis) is a common infection that most women suffer from at some time in their lives and is not caused by lack of personal hygiene.
Possible side effects
Thrush is caused by a yeast (fungus) called Candida which lives harmlessly in the vagina and other parts of the body, without you even noticing it. However, the natural balance that keeps Candida under control can be upset by many factors such as hormonal changes (menstruation, contraceptive pill, pregnancy, menopause), poor health, antibiotics, perfumed soaps, bath additives and tight clothing.
Do not put the cream in your mouth or swallow it. If the cream is swallowed accidentally, tell your doctor straight away or contact the Accident and Emergency Department of your nearest hospital. Like all medicines, Canesten Thrush Internal Cream can cause side effects, although not everybody gets them. As with all medicines, some people may be allergic to the cream. If you are allergic, a reaction will occur soon after you have used the medicine. If you experience an allergic reaction or the redness, burning, pain, itching or swelling get worse, stop using this product and tell your doctor straight away or contact the Accident and Emergency Department of your nearest hospital. Signs of an allergic reaction may include:
- Rash.
- Swallowing or breathing problems.
- Swelling of your lips, face, throat or tongue.
- Weakness, feeling dizzy or faint.
- Nausea. After you apply Canesten Thrush Internal Cream you might experience:
- Itching, rash, swelling, redness, discomfort, burning, irritation, vaginal peeling, discharge or bleeding.
- Pain (eg. abdominal pain, vulvovaginal pain).
- Nausea. If you experience any of the above effects, tell your doctor or pharmacist immediately. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
How to store it
CANESTEN® THRUSH INTERNAL CREAM
If the natural pH balance is altered, the level of yeast increases and can develop into a thrush infection causing any of the following symptoms: persistent burning and/or itching around the vagina and vulva, redness, swelling and soreness of the tissues of the vagina and vulva and a whitish, odourless discharge from the vagina. Not everybody who has thrush has all these symptoms; you may have only one of them. How to avoid future recurrences: ✓ Wear cotton knickers and loose clothing. ✓ Wash daily. ✓ After going to the toilet, wipe yourself from the front to back as a thrush infection may be transferred from the bowel. ✓ Change your sanitary protection regularly. ✗ Try to avoid wearing tights, nylon knickers and close fitting jeans. ✗ Try to avoid washing with perfumed soaps or using vaginal deodorants. ✗ Do not wash or rub yourself hard with sponges or flannels and avoid hot baths with strong perfumed oils. If you are still worried or have any questions about the symptoms or the treatment of thrush, do not hesitate to ask your doctor or pharmacist for advice. For UK residents only: if you have any questions or would like more information, call our Canesten Advice Line on 0845 758 5030. Calls charged at local rate. This leaflet was last revised in March 2021. Canesten is a registered trademark of Bayer AG, Germany.
Keep this medicine out of the sight and reach of children. Do not store above 25°C. Do not use Canesten Thrush Internal Cream after the expiry date which is stated at one end of the carton, on the applicator and on the applicator foil wrapping. The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
8092735-17
Frequently asked questions about Canesten Thrush Internal Cream 10% w/w vaginal cream
How do I take Canesten Thrush Internal Cream 10% w/w vaginal cream?
Canesten Thrush Internal Cream 10% w/w vaginal cream comes as cream. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
What is the active substance in Canesten Thrush Internal Cream 10% w/w vaginal cream?
The active substance in Canesten Thrush Internal Cream 10% w/w vaginal cream is clotrimazole.
Are there equivalent medicines to Canesten Thrush Internal Cream 10% w/w vaginal cream?
Medicines with the same active substance, strength and form include: Boots Antifungal Cream, Boots Thrush 1% w/w Cream, Canesten 10% w/w Vaginal Cream. In total there are 7 equivalent products. They are interchangeable only if your prescriber or pharmacist says so.
Where does this information come from?
This leaflet reproduces the patient information leaflet approved for Canesten Thrush Internal Cream 10% w/w vaginal cream, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Can I get Canesten Thrush Internal Cream 10% w/w vaginal cream without a prescription?
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
About this leaflet
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
- Source: electronic medicines compendium (emc), Datapharm
- Active substance: clotrimazole
- Official document: view the original leaflet on emc →
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
4.1. Therapeutic indications
Canesten Thrush Internal Cream is indicated for the treatment of candidal vaginitis.
4.2. Posology and method of administration
The cream should be administered intravaginally using the applicator supplied.
Adults:
The contents of the filled applicator (5g) should be inserted as deeply as possible into the vagina, preferably at night. A second treatment may be carried out if necessary.
Children:
Not for use in children under 16.
4.3. Contraindications
Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
4.4. Special warnings and precautions for use
Medical advice should be sought if this is the first time the patient has experienced symptoms of candidal vaginitis.
Before using Canesten Thrush Internal Cream, medical advice must be sought if any of the following are applicable:
• more than two infections of candidal vaginitis in the last 6 months.
• previous history of a sexually transmitted disease or exposure to partner with sexually transmitted disease
• pregnancy or suspected pregnancy
• aged under 16 or over 60 years
• known hypersensitivity to imidazoles or other vaginal antifungal products
Canesten Thrush Internal Cream should not be used if the patient has any of the following symptoms whereupon medical advice should be sought:
• irregular vaginal bleeding
• abnormal vaginal bleeding or a blood-stained discharge
• vulval or vaginal ulcers, blisters or sores
• lower abdominal pain or dysuria
• any adverse events such as redness, irritation or swelling associated with the treatment
• fever or chills
• nausea or vomiting
• diarrhoea
• foul smelling vaginal discharge
Treatment during the menstrual period should not be performed due to the risk of the cream being washed out by the menstrual flow. The treatment should be finished before the onset of menstruation.
Do not use tampons, intravaginal douches, spermicides or other vaginal products while using this product.
Vaginal intercourse should be avoided in case of vaginal infection and while using this product because the partner could become infected.
Patients should be advised to consult their physician if the symptoms have not been relieved within one week of using Canesten Thrush Internal Cream.
Canesten Thrush Internal Cream can be used again if the candidal infection returns after 7 days. However, if the candidal infection recurs more than twice within six months, patients should be advised to consult their physician.
This product contains cetostearyl alcohol, which may cause local skin reactions (e.g. contact dermatitis). The product also contains benzyl alcohol which may cause allergic reactions and mild local irritation.
4.5. Interaction with other medicinal products and other forms of interaction
Laboratory tests have suggested that, when used together, this product may cause damage to latex contraceptives. Consequently the effectiveness of such contraceptives may be reduced. Patients should be advised to use alternative precautions for at least five days after using this product.
Concomitant treatment with vaginal clotrimazole and oral tacrolimus (FK- 506; immunosuppressant) might lead to increased tacrolimus plasma levels and similarly with sirolimus. Patients should thus be closely monitored for signs and symptoms of tacrolimus or sirolimus overdosage, if necessary by determination of the respective plasma levels.
4.6. Fertility, pregnancy and lactation
Pregnancy:
There are limited amount of data from the use of clotrimazole in pregnant women. Animal studies with clotrimazole have shown reproductive toxicity at high oral doses (see section 5.3). At the low systemic exposures of clotrimazole following vaginal treatment, harmful effects with respect to reproductive toxicity are not predicted.
Clotrimazole can be used during pregnancy, but only under the supervision of a physician or midwife.
During pregnancy the treatment should be carried out with clotrimazole pessary, since these can be inserted without using an applicator.
Lactation:
There are no data on the excretion of clotrimazole into human milk. However, systemic absorption is minimal after administration and is unlikely to lead to systemic effects. Clotrimazole may be used during lactation.
Fertility:
No human studies of the effects of clotrimazole on fertility have been performed, however, animal studies have not demonstrated any effects of the drug on fertility.
4.7. Effects on ability to drive and use machines
The medication has no or negligible influence on the ability to drive or use machinery.
4.8. Undesirable effects
Frequency not known. As the listed undesirable effects are based on spontaneous reports, assigning accurate frequency of occurrence for each is not possible.
Immune system disorders: anaphylactic reaction, angioedema, hypersensitivity.
Vascular disorder: syncope, hypotension.
Respiratory, thoracic and mediastinal disorders: dyspnea.
Gastrointestinal disorders: abdominal pain, nausea.
Skin and Subcutaneous Tissue Disorders: rash, urticaria, pruritus.
Reproductive system and breast disorders: vaginal exfoliation, vaginal discharge, vaginal haemorrhage, vulvovaginal discomfort, vulvovaginal erythema, vulvovaginal burning sensation, vulvovaginal pruritus, vulvovaginal pain.
General disorders and administration site conditions: application site irritation, oedema, pain.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
4.9. Overdose
No risk of acute intoxication is seen as it is unlikely to occur following a single vaginal or dermal application of an overdose (application over a large area under conditions favourable to absorption) or inadvertent oral ingestion. There is no specific antidote.
However, in the event of accidental oral ingestion, routine measures such as gastric lavage should be performed only if clinical symptoms of overdose become apparent (e.g. dizziness, nausea or vomiting). Gastric lavage should be carried out only if the airway can be protected adequately.
💬 Ask about this leaflet
Ask anything about Canesten Thrush Internal Cream 10% w/w vaginal cream. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.
Medicines containing Clotrimazole
- Canesten 10% w/w Vaginal Cream
- Canesten 100mg Pessary
- Canesten 200mg Pessary
- Canesten 500mg Pessary
- Canesten Athlete's Foot 1% w/w Cream
- Canesten Combi Pessary & External Cream 500mg / 2% w/w pessary & cream
- Canesten Combi Soft Gel Pessary & External Cream 500mg / 2% w/w vaginal capsule & cream
- Canesten Cream
- Canesten Dermatological Spray
- Canesten Solution
- Canesten Thrush Combi Internal & External Creams 10% w/w / 2% w/w vaginal cream & cream
- Canesten Thrush Combi Soft Gel Pessary & External Cream 500mg / 2% w/w vaginal capsule & cream
- Canesten Thrush External Cream 2% w/w cream
- Canesten Thrush Pessary 500mg pessary