Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.

Pharmacy Guide

Patient leaflets and SmPCs, drug interaction checker, official dosages and NHS pharmacy opening hours — all in one place.

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Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM

⚠ This medicine appears to have been discontinued

The electronic medicines compendium (emc) no longer publishes a Summary of Product Characteristics for this product, which usually means it is no longer marketed in the UK. The patient leaflet below is kept for reference, but the product may not be available.

If you were prescribed this medicine, other products containing Glycopyrronium may still be available. Do not stop your treatment — ask your pharmacist or GP what to use instead.

Active substance: Glycopyrronium
Source: electronic medicines compendium (emc)
Official leaflet: Read the PIL on emc

What it is and what it is used for

for

Axhidrox contains the active substance glycopyrronium and belongs to a group of sweat reducing medicines called antihidrotics. Axhidrox is used for topical treatment of severe primary axillary hyperhidrosis in adults. Primary axillary hyperhidrosis causes excessive sweating in both armpits without any apparent reason like sports, hard physical work, hot weather, certain diseases or medicines. A feature of primary axillary hyperhidrosis is that it occurs usually during the day but not during sleep. External use of Axhidrox in the armpits leads to reduced sweat production in the sweat glands. 2.

What you need to know before you take it

e Axhidrox

Do not use Axhidrox if you

  • are allergic to glycopyrronium or any of the other ingredients of this medicine (listed in section 6).
  • have an eye disease where the pressure is high in your eye (glaucoma).
  • have or have had acute bleeding with unstable heart and blood circulation status.
  • have a chronic inflammatory disease of the large bowel (severe ulcerative colitis).

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  • have or have had a chronic inflammation of the large bowel complicated by severe extension of the colon (toxic megacolon complicating ulcerative colitis).
  • have or have had a blockage of the bowel as a result of paralysis of the bowel muscles (paralytic ileus).
  • have an immune response disease affecting muscles (myasthenia gravis) or the salivary or lacrimal glands (Sjögren syndrome). Warnings and precautions Talk to your doctor or pharmacist before using Axhidrox, if you:
  • have or have had prostate or bladder problems, or problems passing urine. Stop using this medicine and consult a doctor if you notice symptoms of urinary retention like urination in a weak stream or drops, increased need to urinate, feeling of a full or insufficiently emptied bladder.
  • have severe kidney disorders, including dialysis-dependent kidney failure.
  • have dysfunctions of the blood brain barrier, such as after traumatic brain injury within the past year, chemotherapy, radiation therapy of the head, surgery of the skull and brain, or due to intravenous drug abuse.
  • have a heart disease, heart failure, irregular heartbeat or high blood pressure.
  • have inflamed or injured skin of the armpits since this may increase the risk of local side effects. Use Axhidrox only after complete remission of the skin disease or after healing of the wound. Do not apply the cream to any other part of the body than the armpits and avoid any contact of the cream with the eyes, nose or mouth or with other persons.
  • Apply Axhidrox with the dispenser cap only, not with your fingers. If the cream gets into the eyes, it can cause temporary enlargement of the pupils and blurred vision. If any cream gets into the mouth or nose, the production of saliva or nasal secretions may be reduced. If the eyes, nose or mouth come in contact with the cream, these areas should be immediately rinsed with plenty of water to reduce the risk of local side effects.
  • Cover the treated armpits with clothes during intercourse because side effects cannot be ruled out in case other persons come in contact with the cream. If you notice a dry mouth, carefully clean your teeth. Have your teeth checked regularly by your dentist, as the risk of caries can be increased. Children Do not use Axhidrox in children under 18 years because the safety and efficacy of this medicine has not been studied in this age group. Other medicines and Axhidrox Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines. Some medicines may affect or be affected by Axhidrox. These medicines include:
  • topiramate, used to treat epilepsy and migraine
  • sedative antihistamines, used to treat allergies or sleep disorders V01
  • tricyclic antidepressants, used to treat depressions
  • monoamine oxidase inhibitors, used to treat depressions or Parkinson's disease
  • neuroleptics or antipsychotics, used to treat mental illness or anxiety
  • opioids, used to treat pain or coughing Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine. There are no data for the use of Axhidrox in pregnant women and it is not known whether the active substance of this medicine passes into human milk. Your doctor will discuss with you whether you can use Axhidrox during pregnancy. If you are breast-feeding, you and your doctor must make a decision whether to discontinue breast-feeding or to discontinue Axhidrox therapy taking into account the benefit of breast-feeding for your child and the benefit of therapy for you. This is because your baby should not come in contact with the cream or the treated skin. Driving and using machines Blurred vision, drowsiness, tiredness and dizziness may occur following administration of Axhidrox (see section 4). Blurred vision in particular may occur if Axhidrox gets into the eyes. Do not drive, use machines or perform dangerous work or sports until these effects disappear. Axhidrox contains benzyl alcohol, propylene glycol and cetostearyl alcohol This medicine contains 2.7 mg benzyl alcohol per pump actuation. Benzyl alcohol may cause allergic reactions and mild local irritation. This medicine contains 8.1 mg propylene glycol per pump actuation. This medicine contains cetostearyl alcohol which may cause local skin reactions (e.g. contact dermatitis). 3.

How to take it

Axhidrox

Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Apply Axhidrox only on the skin in your armpits and only with the cap of the pump, not with your fingers (see section 2, "Warnings and precautions"). The recommended dose is two pump actuations per armpit. During the first 4 weeks of treatment, apply Axhidrox to each armpit evenly, once a day, preferably in the evening. From the 5th week on, you may reduce the frequency of application to twice a week, depending on the reduction of sweat production. Preparation of the pump before the first use To obtain the recommended dose, you must remove the air trapped in the pump, as follows:

  • Pull off the cap of the pump.
  • Put a piece of paper on the table. Hold the pump at an angle (see illustration), press the pump down repeatedly until cream comes out of the opening. V01
  • Slowly push the pump down fully another 10 times and put the dispensed cream onto the paper. Dispose the paper with the dispensed cream in the waste bin only.
  • The pump is now ready for use. Repeated preparation of the pump is not necessary for subsequent use. Application of the cream with the cap of the pump
  • Pull off the cap of the pump.
  • Hold the pump in your hand with the opening of the pump towards the removed cap.
  • Press the pump all the way down twice to apply the recommended amount of cream to the top of the cap (see illustration).
  • Evenly distribute the cream with the cap in one armpit.
  • Repeat this process for the second armpit.
  • Afterwards, you must wash the cap of the pump and, for safety, your hands immediately and thoroughly with soap and water. This is important to avoid contact of the cream with nose, eyes or mouth (see section 2, "Warnings and precautions").
  • Tick off the number of treatments in the table on the outer carton (see section 6). One treatment corresponds to 4 pump actuations, i.e. 2 pump actuations per armpit. If you use more Axhidrox than you should Overdosing is unlikely to occur if you use Axhidrox only in the armpits as described. However, if Axhidrox is applied too frequently or excessively, the possible side effects may increase (see section 4). Therefore, Axhidrox must not be used on other parts (palms, feet, face) or on large areas of the body with increased sweating. Excessively reduced sweating could lead to overheating of the body and possibly life-threatening heatstroke. Stop using Axhidrox and seek medical advice immediately if you notice an increasing sensation of heat or increased body temperature. If you forget to use Axhidrox Do not use a double dose to make up for a forgotten dose. If you stop using Axhidrox If you or your doctor decide to stop using Axhidrox, excessive sweating will occur again. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 4.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop using Axhidrox and contact your doctor or nearest emergency department immediately, if you get the following serious side effect:

  • swelling mainly of the face, lips or throat which makes it difficult to swallow or breathe, itching and rashes. This could be a sign of a severe allergic reaction or angioedema (frequency not known, cannot be estimated from the available data), so that you may need urgent medical treatment.
  • blurred vision (common side effect) (see section 2, "Driving and using machines"). V01

The following further side effects were observed: Very common side effect (may affect more than 1 in 10 people)

  • dry mouth Common side effects (may affect up to 1 in 10 people)
  • in the treated armpit: irritation, pain, itching, eczema, skin inflammation, rash, skin reddening, nodules
  • dry nose
  • dry eyes
  • dry skin
  • headache
  • constipation Uncommon side effects (may affect up to 1 in 100 people)
  • in the treated armpit: dryness, acne, swelling, hardening of the skin, scar, small blisters, wound, pustules, inflamed hair follicle
  • eczema
  • itching, itching all over the body
  • skin rash
  • skin reddening
  • long-term skin eczema (atopic dermatitis)
  • skin irritation
  • skin plaque (raised, firm, superficial skin changes over 1 cm in size)
  • acne
  • nettle rash
  • abnormal body odour
  • skin condition resembling psoriasis (parapsoriasis)
  • dry lips, hands, mucous membrane, throat
  • absence of saliva
  • blocked nose
  • itchy, red or irritated eyes
  • different sizes of pupils
  • dilated pupils
  • visual impairment
  • abdominal distension
  • hard stools
  • indigestion
  • nausea V01
  • pain in the mouth and throat
  • throat tightness
  • drowsiness
  • tiredness
  • disturbed attention
  • anxiety
  • restlessness
  • disturbed sleep, poor quality sleep
  • dizziness
  • head discomfort
  • disturbed bladder emptying
  • excessive sweating
  • reduced number of blood platelets seen in blood test
  • high heart rate
  • alteration of the heart rhythm (called "prolonged QT interval", seen on ECG, electrical activity of the heart)
  • increased liver enzymes, bilirubin and volume of red blood cells seen in blood test
  • decreased concentration of haemoglobin in red blood cells seen in blood test Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible

Possible side effects

not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or apple App Store.By reporting side effects you can help provide more information on the safety of this medicine. 5.

How to store it

Axhidrox

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the label and on the carton after 'EXP'. The expiry date refers to the last day of that month. This medicine does not require any special storage conditions. After first pump actuation, the medicine may be used for a maximum of 12 months. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment. 6.

Contents of the pack and other information

What Axhidrox contains

  • The active substance is glycopyrronium (as glycopyrronium bromide). 1 g cream contains glycopyrronium bromide, equivalent to 8 mg glycopyrronium. One V01

actuation of the pump delivers 270 mg cream which contains glycopyrronium bromide, corresponding to 2.2 mg glycopyrronium.

  • The other ingredients are benzyl alcohol (E1519), propylene glycol (E1520) and cetostearyl alcohol (see section 2), citric acid (E330), glycerol monostearate 40-55, macrogol 20 glycerol monostearate, sodium citrate (E331), octyldodecanol and purified water. What Axhidrox looks like and contents of the pack Axhidrox is a white glossy cream, available in packs containing one multidose container with a pump and a cap. The multidose container contains 50 g cream. After pump preparation, the pump delivers 124 pump actuations which are sufficient for 31 treatments of both armpits. Tick the number of treatments in the table on the outer carton. After 31 treatments, you should not continue to use the pump, even if the multidose container is not completely empty. Marketing Authorisation Holder axunio Pharma GmbH Van-der-Smissen-Straße 1 22676 Hamburg Germany Manufacturer Dr. August Wolff GmbH & Co. KG Arzneimittel Sudbrackstrasse 56 33611 Bielefeld, GERMANY This leaflet was last revised in 2025-07-17.

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Frequently asked questions about Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM

How do I take Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM?

Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM comes as cream containing 2.2mg / 2.2mg / 270mg. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.

What is the active substance in Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM?

The active substance in Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM is glycopyrronium.

Where does this information come from?

This leaflet reproduces the patient information leaflet approved for Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.

Can I get Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM without a prescription?

Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.

About this leaflet

The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.

Medical disclaimer: This page is for information only and does not replace advice from your doctor or pharmacist. Always read the leaflet supplied with your medicine. If you are unwell, call NHS 111; in an emergency, call 999.

Medicines with the same active substance: Glycopyrronium (1 medicine)
See every medicine containing this substance, or browse the full A–Z of active substances.
⚕For healthcare professionals — Summary of Product Characteristics (SmPC)Full SmPC: dosage, interactions, contraindications, warnings+
Technical information intended for healthcare professionals (doctors and pharmacists). The Summary of Product Characteristics (SmPC) is the official document approved by the MHRA/EMA. It does not replace the patient leaflet or a doctor’s advice.

4.1. Therapeutic indications

Axhidrox is indicated for the topical treatment of severe primary axillary hyperhidrosis in adults.

4.2. Posology and method of administration

Cutaneous use

Axhidrox is for topical use in the underarm area only and not for use in other body areas.

Posology

The recommended dosage of Axhidrox is two pump actuations per armpit (equivalent to 540 mg of cream or 4.4 mg glycopyrronium per armpit). After priming, the pump must be pressed down all the way twice to get the desired dose of 540 mg cream (4.4 mg glycopyrronium).

During the first 4 weeks of treatment, Axhidrox is applied to each armpit evenly, once a day, preferably in the evening.

From the 5th week on, the frequency of application of Axhidrox may be reduced to twice a week, depending on the reduction of axillary sweating.

Continuous treatment of primary axillary hyperhidrosis with Axhidrox is required to maintain the effect.

Paediatric population

The safety and efficacy of Axhidrox in children and adolescents under 18 years has not yet been established.

No data are available.

Elderly

The safety and efficacy of Axhidrox in the elderly population above 65 years has not been established.

Renal impairment

Axhidrox can be used at the recommended dose in patients with mild or moderate renal impairment. In patients with severe renal impairment or end-stage renal disease requiring dialysis Axhidrox should be used only if the expected benefit outweighs the potential risk since the systemic exposure to glycopyrronium may be increased in this population (see section 4.4).

Hepatic impairment

No studies have been conducted in patients with hepatic impairment. Glycopyrronium is predominantly cleared by renal excretion and therefore no major increase in exposure to the active substance is to be expected in patients with hepatic impairment.

No dose adjustment is required in patients with hepatic impairment.

Method of administration

Preparation of the pump before the first use

The multidose container requires priming before it is used for the first time.

To get a full initial dose, the air trapped in the pump must be removed as follows:

– Hold the pump at an angle (see illustration) and repeatedly press the pump down until cream comes out of the opening onto a piece of paper.

– Slowly push the pump down fully another 10 times and put the pumped cream onto the paper. Dispose the paper with the dispensed cream via waste bin only.

– The pump is now ready for use. Repeated preparation of the pump is not necessary for subsequent use.

Regular application of the cream

After priming, the application of the cream is done using the cap as further detailed:

– Hold the pump in one hand with the opening of the pump towards the removed cap of the pump (see illustration).

– Fully press the pump twice to apply the recommended amount of cream to the top of the cap.

– Using the cap, evenly distribute the cream in one armpit.

– Repeat this process for the second armpit.

– Afterwards, for safety, wash the cap and your hands immediately and thoroughly with soap and water. This is important to avoid contact of the cream with nose, eyes or mouth as well as with other persons (see section 4.4).

– Tick off the number of treatments in the table on the outer carton (see section 6).

4.3. Contraindications

– Hypersensitivity to the active substance, or to any of the excipients listed in section 6.1.

– Medical conditions that can be exacerbated by the anticholinergic effect of Axhidrox (e.g. glaucoma, paralytic ileus, unstable cardiovascular status in acute hemorrhage, severe ulcerative colitis, toxic megacolon complicating ulcerative colitis, myasthenia gravis, Sjögren syndrome).

4.4. Special warnings and precautions for use

Axhidrox should be used with caution in patients with severe prostatic hyperplasia, bladder-neck obstruction or a history or presence of urinary retention.

In these patients, doctors and patients should be alert for signs and symptoms of urinary retention (e.g., difficulty passing urine, distended bladder) and patients must be instructed to immediately discontinue the use of Axhidrox and to consult a doctor if any of these signs or symptoms develop.

In patients with severe renal impairment (estimated glomerular filtration rate below 30 ml/min/1.73 m2), including those with end-stage renal disease requiring dialysis, Axhidrox should be used only if the expected benefit outweighs the potential risk. These patients should be monitored closely for potential adverse reactions.

Because an increased heart rate is a known effect of anticholinergics, Axhidrox should be used with caution in patients with coronary artery disease, congestive heart failure, cardiac arrhythmias and hypertension.

No studies have been performed in patients with dysfunctions of the blood-brain barrier (e.g. traumatic brain injuries within the past year, chemotherapy, radiation therapy of the head, surgery to the skull and brain, intravenous drug addicts). Axhidrox should only be used by these patients if other treatment options are not sufficiently effective.

The application of Axhidrox under the armpits should be done only with the cap of the multidose container and not with the fingers. In particular, Axhidrox must not get into the eyes (see section 4.2) since glycopyrronium can cause temporary dilation of the pupils and blurred vision. In case of contact with the mouth or nose, a reduction in the production of saliva or nasal secretions cannot be ruled out. If the eyes, nose or mouth come in contact with the cream, these areas should be rinsed immediately with plenty of water to reduce the risk of local side effects.

In order to exclude side effects, skin to skin contact of the treated skin area with other areas including skin of others should be avoided i.e. by covering the treated area with clothes (e.g. during intercourse).

If the skin of the armpits is visibly inflamed or injured this may increase the risk of local adverse reactions with Axhidrox. Therefore, Axhidrox should only be used after clinical recovery or remission of symptoms of the skin.

Since the use of Axhidrox can cause dry mouth (see section 4.8), increased risk of caries due to the reduced salivation cannot be ruled out. Careful dental hygiene and regular dental health checks are therefore recommended.

Benzyl alcohol may cause allergic reactions and mild local irritations. Cetostearyl alcohol may cause local skin reactions (e.g. contact dermatitis).

4.5. Interaction with other medicinal products and other forms of interaction

No interaction studies have been performed. Co-administration of Axhidrox with other anticholinergic-acting medicinal products has not been studied.

It cannot be ruled out that the concomitant use of these products may result in an increase in anticholinergic effects. This applies, for example, for the use of topiramate, sedative antihistamines, tricyclic antidepressants, monoamine oxidase inhibitors, neuroleptics, antipsychotics and opioids.

4.6. Fertility, pregnancy and lactation

Pregnancy

There are no or limited amount of data from the use of glycopyrronium bromide in pregnant women. Studies in animals have shown reproductive toxicity (see section 5.3). Based on the low systemic exposure following dermal application of Axhidrox, these findings are not considered relevant for human dermal use at the approved dosing. The use of Axhidrox may be considered during pregnancy, if necessary.

Breast-feeding

Studies in lactating rats have shown that glycopyrronium and its metabolites distribute into and is enriched in milk following intravenous and oral application (for details see section 5.3).

The contact of the suckling child with the cream or Axhidrox-treated skin should be avoided, therefore a decision must be made whether to discontinue breast-feeding or to discontinue Axhidrox therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.

Fertility

There are no data on the effect of glycopyrronium on human fertility. Animal studies have shown impaired female fertility at exposures considered in excess of the maximum human exposure, indicating low clinical relevance (see section 5.3).

4.7. Effects on ability to drive and use machines

Axhidrox has moderate influence on the ability to drive and use machines. Blurred vision, fatigue, and dizziness may occur following administration of Axhidrox (see section 4.8). Blurred vision in particular may occur if Axhidrox gets into the eyes (see section 4.4).

4.8. Undesirable effects

Summary of the safety profile

The most common adverse events (> 1%) were application site reactions (15.3%), dry mouth (12.3%), dry eye (3.3%), headache (1.3%), dry skin (1.3%), nasal dryness (1.5%), constipation (1.3%) and blurred vision (1.1%). While dry mouth tended to decrease with longer use, the type and frequency of all other adverse events were similar when using Axhidrox for 4 weeks as well as for 28, 52 or 72 weeks. There was no evidence that adverse events tended to get worse in severity over a longer treatment duration.

Tabulated list of adverse reactions

Adverse reactions in patients using Axhidrox up to 72 weeks are listed by MedDRA system organ class (Table 1). The table also includes data from a 14-day study with 0.5%, 1% and 2% glycopyrronium bromide (GPB) cream respectively.

Within the individual system organ classes, the adverse reactions are ranked by frequency. Within the individual frequency groups, the undesirable effects are indicated in order of decreasing severity. The frequency of adverse effects is defined as follows: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from the available data).

Table 1: Adverse reactions

System organ class

Very common

(≥ 1/10)

Common

(≥ 1/100 to < 1/10)

Uncommon

(≥ 1/1,000 to < 1/100)

Not known

Gastrointestinal disorders

Dry mouth

Constipation

Lip dry, Abdominal distension, Hard stool, Aptyalisam, Dyspepsia, Nausea

Eye disorders

Dry eye, Vision blurred

Eye pruritus, Ocular hyperaemia, Pupils unequal, Visual impairment, Eye irritation, Mydriasis

Respiratory, thoracic and mediastinal disorders

Nasal dryness

Oropharyngeal pain, Throat tightness, Dry throat, Nasal congestion

Nervous system disorders

Headache

Dizziness, Somnolence, Poor quality sleep, Disturbance in attention, Head discomfort

Psychiatric disorders

Sleep disorder, Anxiety, Restlessness

Ear and labyrinth disorders

Vertigo

Skin and subcutaneous tissue disorders

Dry skin

Hyperhidrosis, Pruritus, Pruritus generalized, Rash, Skin odour abnormal, Erythema, Parapsoriasis, Skin irritation, Dry hands, Dermatitis atopic, Eczema, Skin plaque, Acne, Urticaria

General disorders and administration site conditions

Application site dermatitis, eczema, rash, papules, erythema, irritation, pain, or pruritus

Application site acne, swelling, dryness, vesicles, induration, scar or wound, Mucosal dryness, Tiredness

Infections and infestations

Application site folliculitis, pustules

Blood and lymphatic system disorders

Thrombocytopenia

Cardiac disorders

Tachycardia

Immune system disorders

Hypersensitivity, Angioedema

Renal and urinary disorders

Micturition disorder

Investigations

Electrocardiogram QT prolongation, Hepatic enzymes increased, Blood bilirubin increased and Mean cell volume increased, Mean cell haemoglobin concentration decreased

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

4.9. Overdose

Overdosage with Axhidrox is considered unlikely with topical administration to the armpits only.

If Axhidrox is misused on other parts (palms, feet, face) or large areas of the body with increased sweating an increased risk of side effects or an overdose cannot be ruled out. Signs of overdose observed especially with systemic oral administration of glycopyrronium included redness of the skin with a sensation of heat, overheating of the body, life-threatening heatstroke, dryness of the skin and mucous membranes, mydriasis with loss of accommodation, changes in mental status and fever, sinus tachycardia, a decrease in intestinal noises, functional ileus, urinary retention, hypertension, tremors and myoclonic twitching.

In case of severe or life-threatening symptoms, the administration of a quaternary ammonium anticholinesterase, such as neostigmine, should be considered.

🇵🇱 Known in Poland as

Medicines sold in Poland with the same active substance: W Polsce znany jako

⚠ Same active substance, but a different pharmaceutical form (for example a gel instead of a tablet). Not interchangeable — ask a pharmacist.

  • Seebri BreezhalerGlycopyrronii bromidum · inhaler / nebuliser
  • Enurev BreezhalerGlycopyrronii bromidum · inhaler / nebuliser
  • Tovanor BreezhalerGlycopyrronii bromidum · inhaler / nebuliser
  • SialanarGlycopyrronii bromidum · taken by mouth
  • AxhidroxGlycopyrronium
  • AMIDIL AmiHalerGlycopyrronii bromidum · inhaler / nebuliser

Same active substance. The strength, the form and whether you need a prescription can differ. Always ask a pharmacist before you switch. Polish medicines in the UK →

💬 Ask about this leaflet

Ask anything about Axhidrox pump-pack 2.2 mg/pump actuation cream 2.2 mg/270 mg Cream POM. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.

Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.

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