Patient leaflets and SmPCs, drug interaction checker, official and paediatric dosages, pregnancy and breastfeeding guidance, and NHS pharmacy opening hours — all in one place.
Patient leaflets and SmPCs, drug interaction checker, official and paediatric dosages, pregnancy and breastfeeding guidance, and NHS pharmacy opening hours — all in one place.
Adenosine 30mg/10ml Solution for Infusion (called Adenosine Solution for Infusion throughout the rest of this leaflet) belongs to a group of medicines called coronary vasodilators.
Adenosine Solution for Infusion is given with other medicines, called radionuclides, during a diagnostic test, called myocardial perfusion imaging, to open up your heart's blood vessels to allow your blood to flow more freely. Once in your blood, the radionuclide allows the doctor or nurse to see your heart and assess your heart condition.
This medicine is for diagnostic use only and is used if you are incapable of exercise. You will usually be in hospital when you receive this medicine.
Do not have Adenosine Solution for Infusion • if you are allergic to adenosine or any of the other ingredients of this medicine (listed in section 6);
• if you have an irregular heart rhythm and do not currently have a pacemaker fitted;
• if you have a disorder that affects the heart's electrical activity (Long QT syndrome);
• if you have very low blood pressure (severe hypotension);
• if you have unstable angina (severe chest pain) that is not currently controlled by either treatment or medication;
• if you have a type of heart failure where your heart does not pump out enough blood;
• if you have asthma or any other severe breathing problems;
• if you are taking a medicine called dipyridamole, used to thin the blood;
• if you are below 18 years of age. The use of Adenosine Solution for Infusion in children and adolescents has not been sufficiently studied.
Tell your doctor or nurse if any of the following apply to you:
• if you have recently had a heart attack, heart failure, or you have had a heart transplant within the last year;
• if you have a low blood volume level that has not been corrected by either treatment or medication;
• if you have a type of heart disease caused by the narrowing of your heart valves;
• if your heart is inflamed, enlarged, or you have fluid around your heart;
• if you have seizures or convulsions (fits);
• if you have difficulty breathing;
• if you suffer from problems with your autonomic nervous system;
• if you suffer from a narrowing of the main arteries in your neck (carotid arteries) that prevents sufficient blood getting to your brain;
• if you have a known heart defect;
• if you have an unusual heart rhythm (atrial fibrillation or flutter).
.Using other medicines Make sure your doctor or nurse knows if you are taking, or have recently taken, any of the medicines listed here:
• Dipyridamole (used to thin the blood); taking dipyridamole at the same time as Adenosine Solution for Infusion will increase the effect of adenosine on the body. Your doctor or nurse may decide not to give you Adenosine Solution for Infusion, may tell you to stop taking dipyridamole 24 hours before you are given Adenosine Solution for Infusion, or they may lower the dose.
Aminophylline and theophylline (used to help breathing difficulties), or medicines containing Xanthines (caffeine) , which are found in certain medicines used to treat headaches. Your doctor may tell you to stop taking these medicines 24 hours before you are given Adenosine Solution for Infusion.
• Medicines that affect the rate at which your heart conducts electrical impulses such as calcium channel blockers e.g. diltiazem and amlodipine, beta-adrenergic blocking agents e.g. propranolol and metoprolol and centrally acting agents e.g. clonidine and guanfacine.
Please also tell your doctor or nurse if you are taking, or have recently taken, any other medicines, including medicines obtained without a prescription.
Taking Adenosine Solution for Infusion with food and drink • Where possible, do not drink or eat products containing caffeine, such as tea, coffee, chocolate, or cola, for at least 12 hours before you are given Adenosine Solution for Infusion.
Pregnancy and breast-feeding • If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or nurse for advice before they give you this medicine. You should not be given this medicine if you are breast-feeding.
Important information about some of the other ingredients in Adenosine Solution for Infusion • Your medicine contains sodium (salt). This medicinal product contains 3.54mg (0.15mmol) of sodium (salt) per 1ml of solution. To be taken into consideration by patients on a controlled sodium (salt) diet.
You will usually be in hospital when you are given Adenosine Solution for Infusion. You will be given it by a doctor or nurse, as an infusion, into your vein. Your heart and blood pressure will be closely monitored.
Adults and the elderly • The dose is based on your body weight.
• Your doctor or nurse will decide how much to give you.
• The usual dose is 140 micrograms per kilogram, per minute, given over a period of six minutes.
children The safety of Adenosine Solution for Infusion in children is not known. Therefore, it is not recommended for use in children. If the doctor or nurse decides that this medicine is needed, they will determine the most appropriate dose to give.
If you are given too much Adenosine Solution for Infusion As this medicine is given to you by a doctor or nurse, it is unlikely that you will be given too much. However, if you are given too much medicine, the following side effects may occur:
• an extreme lowering in blood pressure;
• a lowering in heart rate;
• a heart problem.
Adenosine stays in the blood for a very short period of time. Therefore, any side effects would soon subside once the infusion has been stopped. You may be given a medicine called aminophylline or theophylline to help with any side effects experienced. If you have any further questions on the use of this medicine, ask your doctor or nurse.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you experience any of the following side effects after you have been given your medicine, tell your doctor or nurse immediately. If you are not in hospital, you MUST GO straight away. • Severe allergic reaction which may include a red and lumpy skin rash, difficulty breathing, swelling of face, mouth, lips or eyelids, unexplained high temperature (fever) and feeling faint. If the swelling affects your throat and makes breathing and swallowing difficult, go to hospital straight away .
• Severe chest pain
• An extreme lowering in heart rate .
• An extreme lowering in blood pressure .
• Respiratory failure .
Very common side effects (may affect more than 1 in 10 people):
• chest pain or pressure on the chest
• flushing (sudden reddening of the skin accompanied by the feeling of heat)
• shortness of breath or the urge to take a deep breath
• headache
• abdominal discomfort
Common side effects (may affect up to 1 in 10 people):
low blood pressure
irregular heart rhythms
• dizziness or feeling light headed
• throat, neck or jaw discomfort
• dry mouth
• numbness, tingling, prickling or burning of the skin
Uncommon side effects (may affect up to 1 in 100 people):
• apprehension (feeling nervous)
• metallic taste in your mouth
• discomfort in the leg, arm or back
• feeling of general weakness, discomfort or pain
• sweating
• slow heartbeat
Rare side effects (may affect up to 1 in 1000 people):
• blurred vision
• nipple discomfort
• ringing or buzzing in your ears (tinnitus)
• feeling the sudden need to urinate
• drowsiness
• blocked nose
• difficulty breathing
• shaking (tremors)
Other side effects which may occur: • fainting or loss of consciousness
• convulsions (fits)
• cardiac arrest (a sudden loss of heart function)
• stopping breathing (respiratory failure or arrest)
• fast, uneven or abnormal heartbeat
• asystole (a severe and fatal heart problem)
• nausea (feeling sick) or vomiting (being sick)
Very rare effects which may occur at the site of injection (affecting up to 1 in 10,000 people):
• redness
• itching
• pain
• abscesses
• swelling
• swollen and painful veins
Not known: frequency cannot be estimated from the available data
• spasm of the artery in the heart which may lead to a heart attack.
You will be observed by medical staff at all times, whilst being given Adenosine Solution for Infusion, to monitor the effects on your heart.
Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: . By reporting side effects you can help provide more information on the safety of this medicine.
This medicine will be stored, by your doctor, nurse or pharmacist out of the sight and reach of children.
This medicine should not be used after the expiry date stated on the carton and vial label. The expiry date refers to the last day of that month.
This medicinal product does not require any special storage conditions.
This product is for single use only. Once your doctor or nurse has opened the vial, it should be used immediately. Any remaining Adenosine Solution for Infusion must be thrown away by the doctor or nurse.
What Adenosine Solution for Infusion contains • The active substance is adenosine. Each 10ml vial contains 30mg adenosine (3mg per ml).
• The other ingredients are sodium chloride and water for injections.
What Adenosine Solution for Infusion looks like and contents of the pack Adenosine Solution for Infusion (Adenosine Infusion) is a clear, colourless solution in a clear, glass vial. Each vial contains 10ml of medicine. This product is available in cartons containing 6 x 10ml vials.
Marketing Authorisation Holder Focus Pharmaceuticals Limited
Dashwood House
69 Old Broad Street
London
EC2M 1QS
UK
Manufacturer Vianex S.A.
Plant A
12km National Road Athinon-Lamias
Metamorfosi Attiki
14451
Greece
For any information about this medicinal product, please contact the Marketing Authorisation Holder, details provided below.
This medicinal product is authorised in the Member States of the EEA under the following names:
United Kingdom: Adenosine 30mg/10ml Solution for Infusion
Greece: ADENORYTHM ® 3mg/ml Διάλυμα για έγχυση
This leaflet was last revised in 02/2026.
Other sources of information
For any information about this medicinal product, please contact Focus Pharmaceuticals Limited Medical Information by phone at +44 (0) 208 588 9131 or by email to [email protected]
ADVANZ Pharma
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Adenosine 30mg/10ml Solution for Infusion comes as infusion containing 30mg / 10ml. Always follow the dose your doctor or pharmacist has given you, and read the leaflet that comes with the medicine.
The active substance in Adenosine 30mg/10ml Solution for Infusion is adenosine.
Medicines with the same active substance, strength and form include: Adenosine 30 mg/10 ml solution for infusion, Adenosine 30mg/10ml Solution for Infusion. They are interchangeable only if your prescriber or pharmacist says so.
This leaflet reproduces the patient information leaflet approved for Adenosine 30mg/10ml Solution for Infusion, as published on the electronic medicines compendium (emc). The version printed inside your medicine’s packaging is the one that applies to you.
Whether a medicine is available over the counter or on prescription only depends on its licence. Check the leaflet, or ask your pharmacist — they can tell you straight away.
The text above reproduces the patient information leaflet approved for this medicine, restructured for easier reading.
Intravenous (IV) Adenosine 30mg/10ml Solution for Infusion is a coronary vasodilator, for use in conjunction with radionuclide myocardial perfusion imaging, in patients who cannot exercise adequately or for whom exercise is inappropriate.
Adenosine 30mg/10ml Solution for Infusion is indicated in adults.
Adenosine 30mg/10ml Solution for Infusion is intended for use in hospitals. It should be administered following the same procedure as for exercise testing, where facilities for cardiac monitoring and cardio-respiratory resuscitation are available for immediate use, if necessary. During administration of Adenosine 30mg/10ml Solution for Infusion, continuous electrocardiogram (ECG) control is necessary, as life-threatening arrhythmia might occur. Heart rate and blood pressure should be monitored every minute.
Adults:
1. Adenosine 30mg/10ml Solution for Infusion should be administered undiluted, as a continuous peripheral intravenous infusion, at a dose of 140 µg/kg/min for six minutes using an infusion pump. Separate venous sites for Adenosine 30mg/10ml Solution for Infusion and radionuclide administration are recommended to avoid an adenosine bolus effect.
2. After three minutes of infusion of Adenosine 30mg/10ml Solution for Infusion, the radionuclide is injected to ensure sufficient time for peak coronary blood flow to occur. The optimal vasodilator protocol is achieved with six minutes of infusion of Adenosine 30mg/10ml Solution for Infusion.
3. To avoid an adenosine bolus effect, blood pressure should be measured in the arm opposite to the infusion of Adenosine 30mg/10ml Solution for Infusion.
The table below is given as a guide for adjustment of the infusion rate of undiluted Adenosine 30mg/10ml Solution for Infusion, in line with bodyweight (total dose 0.84 mg/kg).
Patient Weight (kg)
Infusion Rate (ml/min)
45 - 49
2.1
50 - 54
2.3
55 - 59
2.6
60 - 64
2.8
65 - 69
3.0
70 - 74
3.3
75 - 79
3.5
80 - 84
3.8
85 - 89
4.0
90 - 94
4.2
95 - 99
4.4
100 - 104
4.7
Paediatric population:
The safety and efficacy of Adenosine 30mg/10ml Solution for Infusion in children aged 0 to 18 years have not been established. Currently available data are described in section 5.1 but no recommendation on a posology can be made.
Elderly:
See dosage recommendations for adults.
Adenosine 30mg/10ml Solution for Infusion is contra-indicated in patients suffering from:
- Hypersensitivity to the active substance or to any of the excipients listed in section 6.1
- Second or third degree atrio-ventricular (AV) block, sick sinus syndrome except in patients with a functioning artificial pacemaker
- Long QT syndrome
- Severe hypotension
- Unstable angina not successfully stabilised with medical therapy
- Decompensated states of heart failure
- Chronic obstructive lung disease with evidence of bronchospasm (e.g. asthma bronchiale)
- Concomitant use of dipyridamole (see section 4.5)
Adenosine 30mg/10ml Solution for Infusion is intended for use in a hospital setting with monitoring and cardio-respiratory resuscitation equipment available for immediate use, if necessary. During administration, continuous ECG monitoring is necessary as life threatening arrhythmia might occur (see section 4.2).
Because it has the potential to cause significant hypotension, Adenosine 30mg/10ml Solution for Infusion should be used with caution in patients with left main coronary stenosis, uncorrected hypovolemia, stenotic valvular heart disease, left to right shunt, pericarditis or pericardial effusion, autonomic dysfunction or stenotic carotid artery disease with cerebrovascular insufficiency. Adenosine 30mg/10ml Solution for Infusion should be discontinued in any patient who develops persistent or symptomatic hypotension.
Adenosine 30mg/10ml Solution for Infusion should be used with caution in patients with recent myocardial infarction or severe heart failure. Adenosine 30mg/10ml Solution for Infusion should be used with caution in patients with minor conduction defects (first degree AV block, bundle branch block) that could be transiently aggravated during infusion.
Adenosine may trigger convulsions in patients who are susceptible to convulsions.
Adenosine 30mg/10ml Solution for Infusion should be used with caution in patients with atrial fibrillation or flutter and especially in those with an accessory by-pass tract since particularly the latter may develop increased conduction down the anomalous pathway.
Rare cases of severe bradycardia have been reported. Some occurred in early post-transplant patients; in the other cases occult sino-atrial disease was present. The occurrence of severe bradycardia should be taken as a warning of underlying disease and should lead to treatment discontinuation. Severe bradycardia would favour the occurrence of torsades de pointes, especially in patients with prolonged QT intervals. But to date, no case of torsades de pointes has been reported when adenosine is continuously infused.
The occurrence of respiratory failure (potentially fatal), asystole/cardiac arrest (potentially fatal), angina, severe bradycardia or severe hypotension should also lead to treatment discontinuation.
In patients with recent heart transplantation (less than 1 year) an increased sensitivity of the heart to adenosine has been observed.
Adenosine may precipitate or aggravate bronchospasm (see sections 4.3 and 4.8).
Adenosine 30mg/10ml Solution for Infusion contains 9mg sodium chloride per 1ml (corresponding to 3.54mg of sodium (0.15mmol) per 1ml of solution). To be taken into consideration by patients on a controlled sodium diet.
Dipyridamole inhibits adenosine cellular uptake and metabolism, and potentiates the action of Adenosine 30mg/10ml Solution for Infusion. In one study, dipyridamole was shown to produce a 4 fold increase in adenosine actions. It is therefore suggested that Adenosine 30mg/10ml Solution for Infusion should not be administered to patients receiving dipyridamole; if use of Adenosine 30mg/10ml Solution for Infusion is essential, dipyridamole should be stopped 24 hours before hand, or the dose of Adenosine 30mg/10ml Solution for Infusion should be greatly reduced.
Aminophylline, theophylline and other xanthines are competitive adenosine antagonists and should be avoided for 24 hours prior to use of Adenosine 30mg/10ml Solution for Infusion.
Food and drinks containing xanthines (tea, coffee, chocolate and cola) should be avoided for at least 12 hours prior to use of Adenosine 30mg/10ml Solution for Infusion.
Adenosine 30mg/10ml Solution for Infusion may interact with drugs tending to impair cardiac conduction.
Pregnancy: There are no or limited amount of data from the use of adenosine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity. Adenosine is not recommended during pregnancy unless the physician considers the benefits to outweigh the potential risks.
Lactation: It is unknown whether adenosine metabolites are excreted in human milk. Adenosine 30mg/10ml Solution for Infusion should not be used during breast-feeding.
Not relevant
Effects related to the known pharmacology of adenosine are frequent, but usually self-limiting and of short duration. Discontinuation of infusion may be necessary if the effect is intolerable.
Methylxanthines, such as IV aminophylline or theophylline have been used to terminate persistent side effects (50-125 mg by slow intravenous injection).
Adverse events are ranked under the heading of the frequency: Very common (>1/10), Common (≥1/100, <1/10), Uncommon (≥1/1000, <1/100), Rare (≥1/10 000, <1/1000), Very rare (<1/10 000), Not known (cannot be estimated from available data).
Cardiac Disorders
Common
- Hypotension, sometimes severe (see section 4.4), Atrio-Ventricular block (see section 4.4), ST segment depression on ECG, sustained or non-sustained ventricular tachycardia
If sustained second or third degree AV block develops, the infusion should be discontinued. If first degree AV block occurs, the patient should be observed carefully as a quarter of patients will progress to a higher degree of block.
Uncommon
- Bradycardia, sometimes severe (see section 4.4)
Not known
- Sinus tachycardia, atrial fibrillation, ventricular fibrillation, asystole/cardiac arrest (sometimes fatal, especially in patients with underlying ischemic heart disease/cardiac disorder, (see section 4.4))
- Arteriospasm coronary which may lead to myocardial infarction.
Nervous System disorders
Very common
- Headache
Common
- Dizziness/Lightheadedness
- Paresthesia
Rare
- Tremor, drowsiness
Not known
- Loss of consciousness/syncope
- Convulsions, especially in predisposed patients (see section 4.4)
Eye disorders
Rare
- Blurred vision
Ear and labyrinth disorders
Rare
- Tinnitus
Respiratory, thoracic and mediastinal disorders
Very common
- Dyspnea (or the urge to take a deep breath)
Rare
- Bronchospasm (see section 4.4)
- Nasal congestion
Very rare
- Respiratory failure (see section 4.4)
Not known
- Apnea/Respiratory arrest
Cases with fatal outcome of respiratory failure, of bronchospasm, and of apnea/respiratory arrest have been reported.
Gastrointestinal disorders
Very common
- Abdominal discomfort
Common
- Dry mouth
Uncommon
- Metallic taste
Not known
- Nausea, vomiting
Renal and Urinary disorders
Rare
- Urinary urgency
Vascular disorders
Very common
- Flushing
General disorders and Administration Site conditions
Very common
- Chest pressure/pain, feeling of thoracic constriction/oppression
Common
- Throat, neck and jaw discomfort
Uncommon
- Sweating
- Discomfort in the leg, arm or back, feeling of general discomfort/weakness/pain
Very rare
- Injection site reactions
Reproductive system and breast disorders
Rare
- Nipple discomfort
Psychiatric disorders
Uncommon
- Nervousness
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.
Overdosage would cause severe hypotension, bradycardia or asystole. The half life of adenosine in blood is very short, and side effects of Adenosine 30mg/10ml Solution for Infusion (when they occur) would quickly resolve when the infusion is discontinued. Administration of IV aminophylline or theophylline may be needed.
Ask anything about Adenosine 30mg/10ml Solution for Infusion. The assistant answers only from this leaflet — if the leaflet does not cover it, it will say so. It does not give medical advice.
Answers come from the patient leaflet published on the electronic medicines compendium (emc). They are not medical advice. Ask a pharmacist or your GP if you are unsure. For urgent help call NHS 111, or 999 in an emergency.
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